Neostigmine - CAS 59-99-4
Catalog number: 59-99-4
Category: Inhibitor
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Molecular Formula:
C12H19N2O2
Molecular Weight:
223.33
COA:
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Targets:
AChE
Description:
Neostigmine is a parasympathomimetic compound, which acts as a reversible acetylcholinesterase inhibitor. It is used in the treatment of myasthenia gravis, ogilvie syndrome and urinary retention without the presence of a blockage. It is also used to reverse the effects of muscle relaxants such as gallamine and tubocurarine. It is in the cholinergic family of medications and works by blocking the action of acetylcholinesterase and therefore increases the levels of acetylcholine. It does not cross the blood-brain barrier.
Purity:
98%
Appearance:
Solid powder
Synonyms:
CCRIS 3079; CCRIS3079; CCRIS-3079; 3-[[(Dimethylamino)carbonyl]oxy]-N,N,N-trimethylbenzenaminium;Eustigmin;Eustigmine;Vagostigmine;Prostigmin;Polstigmine
Solubility:
Soluble in DMSO, not in water
Storage:
-20°C Freezer
MSDS:
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Application:
Neostigmine is used in the treatment of myasthenia gravis, ogilvie syndrome and urinary retention without the presence of a blockage. It is also used to reverse the effects of muscle relaxants such as gallamine and tubocurarine.
Quality Standard:
In-house standard
Quantity:
Milligrams-Grams
InChIKey:
ALWKGYPQUAPLQC-UHFFFAOYSA-N
InChI:
InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1
Canonical SMILES:
CN(C)C(=O)OC1=CC=CC(=C1)[N+](C)(C)C
1.Effects of Sugammadex and Neostigmine on Renal Biomarkers.
Isik Y1, Palabiyik O2, Cegin BM3, Goktas U3, Kati I4. Med Sci Monit. 2016 Mar 10;22:803-9.
BACKGROUND Neostigmine, the currently commonly used agent for reversal of neuromuscular blockade. Sugammadex is a novel and unique compound designed as an antagonist of steroidal neuromuscular blockers. In this study, we evaluated the effects of sugammadex or neostigmine on kidney functions in patients scheduled for elective surgery. MATERIAL AND METHODS Patients scheduled for a surgical procedure under desflurane/opioid anesthesia received an intubating dose rocuronium. Patients were divided into 2 groups receiving either sugammadex or neostigmine atropine to reverse neuromuscular blockade. Cystatin C, creatinine, urea, blood urea nitrogen, sodium, potassium, and calcium levels in the blood and α1microglobulin, β2microglobulin, and microalbumin levels in the urine were measured. RESULTS There was no significant difference between the groups with regard to the demographic data. In the Neostigmine Group, although β2microglobulin and microalbumin were similar, a significant increase was found in the postoperative α1microglobulin and cystatin C values.
2.Comparison of sugammadex and neostigmine-atropine on intraocular pressure and postoperative effects.
Hakimoğlu S1, Tuzcu K2, Davarcı I2, Karcıoğlu M2, Ayhan Tuzcu E3, Hancı V4, Aydın S2, Kahraman H5, Elbeyli A3, Turhanoğlu S2. Kaohsiung J Med Sci. 2016 Feb;32(2):80-5. doi: 10.1016/j.kjms.2016.01.009. Epub 2016 Feb 23.
During surgery, changes in intraocular pressure (IOP) can be observed resulting from several factors, such as airway manipulations and drugs used. We aimed to investigate the effects of sugammadex and neostigmine on IOP, hemodynamic parameters, and complications after extubation. Our study comprised 60 patients, aged 18-65 years, with a risk status of the American Society of Anesthesiologists I-II who underwent arthroscopic surgery under general anesthesia. The patients were randomly assigned into two groups. At the end of the surgery, the neuromuscular block was reversed using neostigmine (50 μg/kg) plus atropine (15 μg/kg) in Group 1, and sugammadex (4 mg/kg) in Group 2. Neuromuscular blockade was monitored using acceleromyography and a train-of-four mode of stimulation. IOP was measured before induction and at 30 seconds, 2 minutes, and 10 minutes after extubation. A Tono-Pen XL applanation tonometer was used to measure IOP. This showed that elevation in IOP of patients reversed using sugammadex was similar to that recorded in patients reversed using neostigmine-atropine.
3.Diagnosis of myasthenia gravis: Comparison of anti-nicotinic acetyl choline receptor antibodies, repetitive nerve stimulation and Neostigmine tests at a tertiary neuro care centre in India, a ten year study.
Patil SA1, Bokoliya SC2, Nagappa M3, Taly AB3. J Neuroimmunol. 2016 Mar 15;292:81-4. doi: 10.1016/j.jneuroim.2016.01.006. Epub 2016 Jan 20.
Anti-nicotinic AChR antibodies (Anti-nAChR antibodies), Repetitive Nerve Stimulation (RNS) and Neostigmine test are used for diagnosis of myasthenia gravis (MG). We compared their diagnostic agreement in a cohort of 486 MG patients over a period of ten years. Anti-nAChR antibodies, RNS and Neostigmine test showed positivity of 57.36%, 51.78%, and 93.4% respectively in ocular myasthenia and 93.77%, 82.35%, and 97.92% respectively in generalized myasthenia group. Neostigmine test showed higher positivity than anti-nAChR antibodies and RNS test in both groups. A marginal to fair agreement was observed between these tests highlighting their significance in the diagnosis of the disease.
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CAS 59-99-4 Neostigmine

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