Neostigmine Bromide - CAS 114-80-7
Catalog number:
Not Intended for Therapeutic Use. For research use only.
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Neostigmine bromide(Prostigmin) is a reversible acetylcholinesterase inhibitor and a parasympatho-mimetic.
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1.Under sevoflurane anaesthesia, a reduced dose of neostigmine can antagonize a shallow neuromuscular block: a double-blind, randomised study.
Preault A1, Capron F2, Chantereau C3, Donati F4, Dimet J3. Anaesth Crit Care Pain Med. 2016 Apr 27. pii: S2352-5568(16)30026-1. doi: 10.1016/j.accpm.2015.11.008. [Epub ahead of print]
BACKGROUND: It has been demonstrated that small doses of neostigmine (10-30μ effectively antagonize atracurium blocks at a train-of-four (TOF) ratio of 0.4 under propofol anaesthesia. The results might not be valid with halogenated agents, which potentiate neuromuscular blockades. The goal of this study was to determine the dose of neostigmine required to antagonize a block corresponding to a TOF ratio of 0.4, a level at which fade is not visually detected.
2.Low-Dose or High-Dose Rocuronium Reversed with Neostigmine or Sugammadex for Cesarean Delivery Anesthesia: A Randomized Controlled Noninferiority Trial of Time to Tracheal Intubation and Extubation.
Stourac P1, Adamus M, Seidlova D, Pavlik T, Janku P, Krikava I, Mrozek Z, Prochazka M, Klucka J, Stoudek R, Bartikova I, Kosinova M, Harazim H, Robotkova H, Hejduk K, Hodicka Z, Kirchnerova M, Francakova J, Obare Pyszkova L, Hlozkova J, Sevcik P. Anesth Analg. 2016 May;122(5):1536-45. doi: 10.1213/ANE.0000000000001197.
BACKGROUND: Rocuronium for cesarean delivery under general anesthesia is an alternative to succinylcholine for rapid-sequence induction of anesthesia because of the availability of sugammadex for reversal of neuromuscular blockade. However, there are no large well-controlled studies in women undergoing general anesthesia for cesarean delivery. The aim of this noninferiority trial was to determine whether rocuronium and sugammadex confer benefit in time to tracheal intubation (primary outcome) and other neuromuscular blockade outcomes compared with succinylcholine, rocuronium, and neostigmine in women undergoing general anesthesia for cesarean delivery.
3.A comparison between intrathecal clonidine and neostigmine as an adjuvant to bupivacaine in the subarachnoid block for elective abdominal hysterectomy operations: A prospective, double-blind and randomized controlled study.
Bhar D1, RoyBasunia S1, Das A2, Kundu SB3, Mondal RC4, Halder PS2, Mandal SK2, Chattopadhyay S5. Saudi J Anaesth. 2016 Apr-Jun;10(2):121-6. doi: 10.4103/1658-354X.168797.
BACKGROUND AND AIMS: Adjuvant to the local anesthetic agent has proven benefits when used intrathecally. With regards to intrathecal bupivacaine as control, we have compared in this study the effects of clonidine and neostigmine when co-administered intrathecally with hyperbaric (0.5%) bupivacaine for abdominal hysterectomy.
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CAS 114-80-7 Neostigmine Bromide

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