Nelociguat - CAS 625115-52-8
Catalog number:
625115-52-8
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C19H17FN8O2
Molecular Weight:
408.39
COA:
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Description:
Nelociguat is a soluble guanylate cyclase stimulator (sGC stimulator), which is a key enzyme in the nitric oxide (NO) signalling pathway. It is used for the treatment of pulmonary hypertension. It promotes vasodilation and inhibits smooth muscle proliferation, leukocyte recruitment, platelet aggregation and vascular remodelling through a number of downstream mechanisms. It was also used for erectile dysfunction and heart failure. It was developed by Bayer and was in clinic phase 2 trials with no progress.
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Purity:
98%
Appearance:
Light Tan Solid
Synonyms:
Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate;Carbamic acid, N-[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-, methyl ester;N-Desmethyl Riociguat;Riociguat Imp
Solubility:
DMSO (Slightly)
Storage:
-20°C Freezer
MSDS:
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Application:
Nelociguat is used for the treatment of pulmonary hypertension. It was also used for erectile dysfunction and heart failure.
Quality Standard:
In-house standard
Quantity:
Grams to Kilograms
Boiling Point:
533.3±50.0 °C | Condition: Press: 760 Torr
Melting Point:
>196ºC (dec.)
Density:
1.58±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
FTQHGWIXJSSWOY-UHFFFAOYSA-N
InChI:
InChI=1S/C19H17FN8O2/c1-30-19(29)24-14-15(21)25-17(26-16(14)22)13-11-6-4-8-23-18(11)28(27-13)9-10-5-2-3-7-12(10)20/h2-8H,9H2,1H3,(H,24,29)(H4,21,22,25,26)
Canonical SMILES:
COC(=O)NC1=C(N=C(N=C1N)C2=NN(C3=C2C=CC=N3)CC4=CC=CC=C4F)N
Current Developer:
Nelociguat was developed by Bayer and was in clinic phase 2 trials with no progress.
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