Nelarabine - CAS 121032-29-9
Catalog number:
121032-29-9
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C11H15N5O5
Molecular Weight:
297.27
COA:
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Targets:
Nucleoside Antimetabolite/Analog
Description:
Nelarabine acts by inhibiting DNA synthesis and inducing apoptosis in susceptible cells. Nelarabine demonstrated significant antineoplastic activity with acceptable toxicity.
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Purity:
>98%
Synonyms:
506U78
MSDS:
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1.Nelarabine associated myotoxicity and rhabdomyolysis.
Haider M1, Rizvi SA1, Kasi PM1. Case Rep Hematol. 2015;2015:825670. doi: 10.1155/2015/825670. Epub 2015 Mar 18.
Nelarabine (ara-G; Arranon; compound 506U78) is an antineoplastic purine analog used for the treatment of refractory or relapsed T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL). The drug was granted accelerated approval in October 2005 by the US Food and Drug Administration (FDA) given the efficacy (induction of complete responses) noted in 2 single-arm trials (one in pediatric setting and one in adult patient population). The main spectra of toxicities that have been reported in these clinical trials and subsequent studies are hematological and neurological. Nelarabine induced rhabdomyolysis and increased creatinine phosphokinase (CK; CPK) levels apparently have been reported and this side effect has been added as an adverse reaction in the product monograph from the drug company during postmarketing surveillance. However, the true extent and incidence of the myotoxicity from the drug are unclear. In this paper we report a grade IV CK elevation and rhabdomyolysis in a patient with T-ALL treated with nelarabine.
2.MR imaging in nelarabine-induced myelopathy.
Dua SG1, Jhaveri MD2. J Clin Neurosci. 2016 Feb 16. pii: S0967-5868(16)00005-9. doi: 10.1016/j.jocn.2015.12.014. [Epub ahead of print]
Nelarabine is one of the newer and novel drugs approved by the USA Food and Drug Administration for treatment of relapsed and resistant acute lymphoblastic leukemia. Although there are a few accounts of the neurologic toxicity of nelarabine in the oncological literature, it has never been discussed from a radiologic stand point to our knowledge. We describe a case of nelarabine-induced myelopathy and review the existing literature in an attempt to characterize the MRI features helpful in making an early diagnosis of this elusive entity.
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