Nefopam Hydrochloride - CAS 23327-57-3
Catalog number: 23327-57-3
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C17H19NO.HCl
Molecular Weight:
289.8
COA:
Inquire
Targets:
Others
Description:
Nefopam HCl is a centrally-acting but non-opioid analgesic drug by blocking voltage-gated sodium channel and inhibition of serotonin, dopamine and noradrenaline reuptake.It is widely used, mainly in European countries, for the relief of moderate to severe pain as an alternative to opioid analgesic drugs.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Synonyms:
Nefopam Hydrochloride
MSDS:
Inquire
1.Nefopam inhibits calcium influx, cGMP formation, and NMDA receptor-dependent neurotoxicity following activation of voltage sensitive calcium channels
A. Novelli ,R.Dıaz-Trelles , A. Groppetti, and M. T. Fernandez-Sanchez. Amino Acids (2005) 28: 183–191
Thus, nefopam may share functional and structural properties with other drugs that are used for pathologies other than neuropathic pain, and may be a potential new drug for mood disorders and epilepsy. In addition, although investigations of the application of calcium channel antagonists for the treatment of acute neurodegenerative disorders that are caused by an excessive release of glutamate, such as stroke, have not yet led to the discovery of compounds with efficient neuroprotective activity (Kobayashi and Mori, 1998), it is interesting to note that drugs exerting multiple actions appeared to block the cascades of neuronal death more efficiently than drugs with a single action site (Spedding et al., 1995). For example, an efficient neuroprotective action of flunarizine has been shown in animal models of ischemia (Deshpande and Wieloch, 1986). Flunarizine is a potent non-selective VSCC antagonist which also interacts with Naþ channels. The same effect has also been reported for other VSCC antagonists with little channel selectivity (Benham et al., 1993; Goldin et al., 1995; Varming et al., 1996). Furthermore, a diltiazem analog (T-477) with little selectivity among VSCC types, showed neuroprotective activity in a rat stroke model (Ishii et al., 1996) while the more selective mother compound diltiazem did not show neuroprotection (Wauquier et al., 1985). In conclusion, this study has demonstrated that the analgesic nefopam hydrochloride can reduce calcium influx and effectively prevent intracellular formation of cGMP and neuronal death following the activation of voltage-sensitive calcium channels in cultured cerebellar neurons. Our data are consistent with a presynaptic action of nefopam that may be of interest in reducing the excessive release of endogenous glutamate involved in neurological and neuropsychiatric disorders.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 1493694-70-4 UNC2250

UNC2250
(CAS: 1493694-70-4)

UNC2250 is a potent and selective Mer Kinase inhibitor. When applied to live cells, UNC2250 inhibited steady-state phosphorylation of endogenous Mer with an IC5...

CAS 63238-66-4 Benzoylhypacoitine

Benzoylhypacoitine
(CAS: 63238-66-4)

Benzoylhypacoitine is extracted from the roots of Aconitum carmichaeli Debx. It might be the principal active components which affect mitochondrial growth by Fu...

CAS 1579991-63-1 Chitinase-IN-2

Chitinase-IN-2
(CAS: 1579991-63-1)

Chitinase-IN-2 is a insect chitinase and N- acetyl hexosaminidase inhibitor and pesticide; 50 uM/20uM compound concentration's inhibitory percentage are 98%...

CAS 210110-90-0 Miglustat HCl

Miglustat HCl
(CAS: 210110-90-0)

Miglustat hydrochloride is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1).

CAS 3385-03-3 Flunisolide

Flunisolide
(CAS: 3385-03-3)

Flunisolide is a corticosteroid and used for the treatment of allergic rhinitis.

AEB-1102

AEB-1102 is a derivative of human arginase that is more effective and stable for argine levels modulation compared to native human arginase I. It is potentially...

CAS 108-62-3 Metaldehyde

Metaldehyde
(CAS: 108-62-3)

Metaldehyde, the tetramer form of aldehyde, could be used in the production of other substances and also a pesticide against sorts of gastropods.

FMRF

FMRF is a peptide consisting of 4 amino acid residues.

O4I2
(CAS: 165682-93-9)

O4I2 is a potent inducers of Oct3/4. O4I2 showed high activity in enforcing Oct3/4 expression. O4I2 is a new class of small molecules suitable for iPSC generati...

CAS 153-18-4 Rutin

Rutin
(CAS: 153-18-4)

Rutin, a flavonol glycoside found in many plants including buckwheat; tobacco; forsythia; hydrangea; viola, etc., which possesses healthy effects for human.

CAS 61-78-9 4-Aminohippuric Acid

4-Aminohippuric Acid
(CAS: 61-78-9)

4-Aminohippuric acid is a typical substrate of organic anion transport systems.

CAS 90-45-9 9-Aminoacridine

9-Aminoacridine
(CAS: 90-45-9)

9-Aminoacridine is a highly fluorescent dye, an acridine analog. It is used clinically as a topical antiseptic and experimentally as a mutagen. It is an intrace...

MC-Val-Cit-PAB-OH
(CAS: 159857-80-4)

MC-Val-Cit-PAB-OH, a kind of ADC peptide linker, could be used in the formation of ADC conjugate and be significant in anticancer studies.

CAS 103628-46-2 Sumatriptan

Sumatriptan
(CAS: 103628-46-2)

Sumatriptan is a Serotonin-1b and Serotonin-1d Receptor Agonist that acts selectively at 5HT1 receptors. It is a sulfonamide triptan with vasoconstrictor activi...

CAS 1445879-21-9 GSK2837808A

GSK2837808A
(CAS: 1445879-21-9)

GSK2837808A is a potent and specific lactate dehydrogenase A (LDHA) with IC50values of 1.9 and 14 nM for LDHA and LDHB, respectively and inhibits lactate produc...

CAS 110623-72-8 Epimedin A

Epimedin A
(CAS: 110623-72-8)

Epimedin A, a flavonoids natural product extracted from Herbal Epimedium, could increase cardiovascular blood flow, promote hematopoietic function and has poten...

CAS 1049743-03-4 ARM1 hydrobromide

ARM1 hydrobromide
(CAS: 1049743-03-4)

ARM1 hydrobromide is a novel Leukotriene A4 hydrolase/aminopeptidase (LTA4H) inhibitor (IC50 value of ~0.5 μM in human neutrophils, and Ki value of 2.3 μM for p...

CAS 33996-33-7 Oxaceprol

Oxaceprol
(CAS: 33996-33-7)

Oxaceprol derived from L-proline, inhibiting inflammatory cell infiltration and bone damage in the adjuvant-injected paw.

CAS 1340875-03-7 PRMT3 inhibitor 1

PRMT3 inhibitor 1
(CAS: 1340875-03-7)

PRMT3 inhibitor 1 is an allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3; IC50 value of 1.6 μM for inhibition of full length PRMT3 in a radio...

CAS 202914-84-9 Lomitapide Mesylate

Lomitapide Mesylate
(CAS: 202914-84-9)

Lomitapide Mesylate is a potent microsomal triglyceride transfer protein (MTP) inhibitor, used in the treatment of familial hypercholesterolemia.

Chemical Structure

CAS 23327-57-3 Nefopam Hydrochloride

Quick Inquiry

Verification code

Featured Items