|Description||Nefazodone is a selective serotonin 5-HT2 receptor antagonist. It is an antidepressant under the development of Bristol-Myers Squibb. Its sale was discontinued in some countries due to the rare incidence of hepatotoxicity.|
|Solubility||Soluble in DMSO|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Melting Point||186 - 188℃|
|Current Developer||Bristol-Myers Squibb|
LY 215840 is a potent antagonist of both Serotonin 2A receptor and Serotonin 7 receptor. It can reduce stimulatory effect of serotonin on aldosterone secretion ...
Rupatadine, with the potential to treat allergic rhinitis and urticaria, is a potent and long-lasting dual antagonist of PAF/H1. in vitro: Without affecting con...
Ansofaxine hydrochloride is a triple reuptake inhibitor of serotonin (IC50= 723 nM), dopamine (IC50= 491 nM) and norepinephrine reuptake (IC50= 763 nM).
Dolasetron, a pseudopelletierine derivative, is a 5-HT3 receptor antagonist that could be used to relieve the nausea and vomiting caused by chemotherapy.
Thesuccinate salt form of Frovatriptan, a carbazole derivative, has been found to be a 5-HT receptor agonist that could be used as an antimigraine agent.
Iloperidone displays high affinity (Ki < 10 nM) for norepinephrine alpha(1)-adrenoceptors, dopamine D(3) and serotonin 5-HT(2A) receptors.
Way 100135 is a selective 5-HT1A receptor antagonist originated by Wyeth with IC50 value of 15 nM. IC 50 values for 5-HT1B, 1C, 2,α1, α2 and D2 receptors are ov...
A labelled form of Ziprasidone which is an antagonist of both 5-HT and dopamine receptor and it has been studied to show effective antipsychotic activity.
LY 125180 is a serotonin antagonist.It can effect on serotonin uptake and serotonin synthesis in rat brain in vitro and in vivo.
Alprenolol is a non-selective Beta-Adrenergic receptor and 5-HT1A receptor antagonist for the treatment of angina pectoris.
Tandospironeis a potent and selective 5-HT1A receptor partial agonist with Ki of 27 nM. It significantly reduces haloperidol-induced bradykinesia in a dose depe...
MK212 hydrochloride is a selective 5-HT2C serotonin receptor agonist. It displays selectivity for 5-HT2C over 5-HT2A with IC50 values of 0.028 and 0.42 μM for h...
Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic.
Lasmiditan is a high-affinity, highly selective 5-HT1F receptor agonist(Ki=2.1 nM) for the treatment of acute migraine.
Vortioxetine (Lu AA21004) is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with IC50 of 15 nM, 33 nM, 3.7 nM, 19 nM ...
A potent dual antagonist of α1-adrenergic receptor and 5-HT2 receptor
The hydrochloride salt form of Alosetron, a 5HT3-receptor antagonist, could be used against bowel syndrome.
GSK215083 is a PET radioligand for the 5-hydroxytrypamine-6 (5HT6) receptor. It is a quinoline based compounds that acts by antagonising the 5-HT6 receptor. It ...
Tianeptine is a selective facilitator of 5-HT uptake in vitro and in vivo with psychostimulant, anti-ulcer and anti-emetic properties.
SB269970 HCl is a hydrochloride salt form of SB-269970, which is a 5-HT7 receptor antagonist with pKi of 8.3, exhibits >50-fold selectivity against other recept...