Necrox-5 (methanesulfonate) - CAS 1383718-29-3
Catalog number:
1383718-29-3
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C25H31N3O3S • 2CH4O3S
Molecular Weight:
645.8
COA:
Inquire
Targets:
mitochondria
Description:
Necrox-5 is a cell permeable necrosis inhibitor with the antioxidant and cardioprotective effects. It localizes mainly in the mitochondria that selectively blocks oxidative stress-induced necrotic cell death (0.1μM NecroX™-5 prevented ~50% cell death in H9C2 cells exposed to 400μM t-BuOOH for 2 hours LDH assay used). Necrox-5 was demonstrated that protect cells from oxidative stress, hypoxia, cold shock, CCl4-induced liver injury and chronic liver fibrosis.
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Brife Description:
cell permeable necrosis inhibitor, mitochondria
Purity:
≥98 %
Appearance:
Solid Powder
Synonyms:
5-[(1,1-dioxido-4-thiomorpholinyl)methyl]-2-phenyl-N-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-7-amine, dimethanesulfonate; Necrosis Inhibitor 5
Solubility:
Soluble in DMSO (>10mg/ml) or distilled water (>10mg/ml)
Storage:
Store in a cool and dry place and at 0-4 ℃ for short term (days to weeks) or -66 ℃ for long term (months to years).
MSDS:
Inquire
Application:
A cell permeable necrosis inhibitor with the antioxidant and cardioprotective effects.
Shelf Life:
2 years
InChIKey:
ZWWWDIWEZYRVMB-UHFFFAOYSA-N
InChI:
InChI=1S/C25H31N3O3S.2CH4O3S/c29-32(30)12-8-28(9-13-32)18-20-14-22-16-23(21-4-2-1-3-5-21)27-25(22)24(15-20)26-17-19-6-10-31-11-7-19;2*1-5(2,3)4/h1-5,14-16,19,26-27H,6-13,17-18H2;2*1H3,(H,2,3,4)
Canonical SMILES:
O=S(CCN1CC2=CC(NCC3CCOCC3)=C(NC(C4=CC=CC=C4)=C5)C5=C2)(CC1)=O.OS(C)(=O)=O.OS(C)(=O)=O
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