ND-630 - CAS 1434635-54-7
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C28H31N3O8S
Molecular Weight:
569.63
COA:
Inquire
Targets:
Others
Description:
ND-630, also called as NDI 010976, is a highly selective, reversible inhibitor of acetyl-CoA carboxylase (ACC) and had IC50 values of 2 and 7 nM for ACC1 and 2, respectively, EC50 values in HepG2 serum free and 10% serum of 9 and 66 nM, respectively, and 2-fold C2C12 fatty acid oxidation (FAOxn) stimulation at 200 nM.
Publictions citing BOC Sciences Products
  • >> More
Brife Description:
An acetyl-CoA carboxylase (ACC) inhibitor
Synonyms:
2-[1-[(2R)-2-(2-methoxyphenyl)-2-(oxan-4-yloxy)ethyl]-5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxothieno[2,3-d]pyrimidin-3-yl]-2-methylpropanoic acid
Solubility:
DMSO: ≥ 50 mg/mL
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
Inquire
Boiling Point:
779.0±70.0 ℃ at 760 Torr
Density:
1.42±0.1 g/cm3
InChIKey:
ZZWWXIBKLBMSCS-FQEVSTJZSA-N
InChI:
1S/C28H31N3O8S/c1-16-21-24(32)31(28(2,3)26(33)34)27(35)30(25(21)40-22(16)23-29-11-14-38-23)15-20(39-17-9-12-37-13-10-17)18-7-5-6-8-19(18)36-4/h5-8,11,14,17,20H,9-10,12-13,15H2,1-4H3,(H,33,34)/t20-/m0/s1
Canonical SMILES:
CC1=C(SC2=C1C(=O)N(C(=O)N2CC(C3=CC=CC=C3OC)OC4CCOCC4)C(C)(C)C(=O)O)C5=NC=CO5
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 882697-00-9 Anle138b

Anle138b
(CAS: 882697-00-9)

Anle138b is a novel fluorescent oligomer modulator and an aggregation inhibitor. In vitro, anle138b blocked the formation of pathological aggregates of prion pr...

CAS 13657-68-6 Germacr-1(10)-ene-5,8-dione

Germacr-1(10)-ene-5,8-dione
(CAS: 13657-68-6)

Curdione, a sesquiterpene compound, could probably be a candidate for inflammatory study and cancer chemopreventive agents.

CAS 102-76-1 Triacetin

Triacetin
(CAS: 102-76-1)

Triacetin, an non-ionic surfactant, could be widely used because of its characteristics like dispersion, emulsification and solubilization capacity. The FEMA nu...

FR-181074
(CAS: 184147-65-7)

FR-181074 may be a bio-active chemical to treat Male Sexual Dysfunction.

CP-60949-4
(CAS: 17518-97-7)

CP-60949-4, a quinazolin derivative, could be probably useful in sorts of biological studies.

CAS 920509-32-6 MGL-3196

MGL-3196
(CAS: 920509-32-6)

MGL-3196 is a first-in-class, orally available, once-daily and liver-directed thyroid hormone receptor (THR) beta-selective agonist. Studies suggest that MGL-31...

Herzuma

Herzuma is a biosimilar of trastuzumab approved by EU for the treatment of patients with early breast cancer, metastatic breast cancer or metastatic gastric can...

CAS 1579991-61-9 Chitinase-IN-1

Chitinase-IN-1
(CAS: 1579991-61-9)

Chitinase-IN-1 is a insect chitinase and N- acetyl hexosaminidase inhibitor and pesticide; 50 uM/20uM compound concentration's inhibitory percentage are 75%...

CAS 1478364-68-9 PXS 4728A

PXS 4728A
(CAS: 1478364-68-9)

PXS 4728A is a VAP-1 (aka SSAO/AOC3) inhibitor with IC50 values 5 nM in the clinical trial for the treatment of non-alcoholic steatohepatitis (NASH). Studies sh...

CAS 149301-79-1 AACOCF

AACOCF
(CAS: 149301-79-1)

AACOCF, an anlogue of arachidonic acid, is a slow-binding inhibitor of cytosolic (85 kDa) phospholipase A2. It also inhibits fatty acid amide hydrolase (FAAH, a...

MI 2 dihydrochloride

MI 2 dihydrochloride is a Menin-MLL interaction inhibitor. MI-2 can bind menin and block the menin-MLL fusion protein interaction with IC50 value of 0.45 μM. It...

CAS 61281-38-7 Schisandrin A

Schisandrin A
(CAS: 61281-38-7)

Schizandrin A is extracted from the seeds of Schisandra chinensis (Turcz.) Baill that is reported to have liver-protective, antitumor, and antioxidant activitie...

CAS 66504-75-4 Bicifadine hydrochloride

Bicifadine hydrochloride
(CAS: 66504-75-4)

Bicifadine hydrochloride is a potent antagonist of SLC6A2 (noradrenalin transporter) (IC50 = 55 nM). Bicifadine also has antagonistic activity at the 5-HT recep...

CAS 68370-47-8 Micheliolide

Micheliolide
(CAS: 68370-47-8)

Micheliolide could effectively attenuate the high glucose-stimulated activation of NF-κB, the degradation of IκBα, and the expression of MCP-1, TGF-β1 and FN in...

CAS 127-31-1 Fludrocortisone

Fludrocortisone
(CAS: 127-31-1)

Fludrocortisone, a kind of mineralocorticoid, could be used against cerebral salt wasting syndrome for behaving the role as a anti-inflammatory agent.

CAS 524708-03-0 APE1 Inhibitor III

APE1 Inhibitor III
(CAS: 524708-03-0)

APE1 Inhibitor III is a selective and competitive inhibitor of apurinic/apyrimidinic (AP) endonuclease 1 (APE1) with 2.0 micromolar activity against the purifie...

CAS 173352-39-1 Afobazole hydrochloride

Afobazole hydrochloride
(CAS: 173352-39-1)

Fabomotizole (brand name Afobazole) is an anxiolytic drug launched in Russia in the early 2000s. It produces anxiolytic and neuroprotective effects without any ...

CAS 505-44-2 Iberin

Iberin
(CAS: 505-44-2)

Iberin, a naturally occurring member of isothiocyanate family found in cruciferous plants, inhibits cell survival (IC50= 2.3 μM in HL60 cell).

CAS 501036-69-7 BigLEN (mouse)

BigLEN (mouse)
(CAS: 501036-69-7)

BigLEN (mouse) is a proSAAS-derived neuropeptide that acts as a GPR171 agonist. It regulates food intake in mice, and suppresses the release of glutamate onto p...

CAS 96020-91-6 Eflornithine hydrochloride, hydrate

Eflornithine hydrochloride, hydrate
(CAS: 96020-91-6)

Eflornithine hydrochloride, hydrate is a drug found to be effective in the treatment of facial hirsutism. It is a "suicide inhibitor," irreversibly binding to O...

Chemical Structure

CAS 1434635-54-7 ND-630

Quick Inquiry

Verification code

Featured Items