NCT-503 - CAS 1916571-90-8
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C20H23F3N4S
Molecular Weight:
408.48
COA:
Inquire
Targets:
Others
Description:
NCT-503 is a non-competitive phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50= 2.5 µM), reducing the production of glucose-derived serine in cells and suppressing the growth of PHGDH-dependent cancer cells in culture and in orthotopic xenograft tumors.
Publictions citing BOC Sciences Products
  • >> More
Synonyms:
N-(4,6-dimethylpyridin-2-yl)-4-[[4-(trifluoromethyl)phenyl]methyl]piperazine-1-carbothioamide
Solubility:
DMSO: 10 mM
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
Inquire
Boiling Point:
474.3±55.0 ℃ at 760 Torr
Density:
1.306±0.06 g/cm3
InChIKey:
PJNSZIQUFLWRLH-UHFFFAOYSA-N
InChI:
1S/C20H23F3N4S/c1-14-11-15(2)24-18(12-14)25-19(28)27-9-7-26(8-10-27)13-16-3-5-17(6-4-16)20(21,22)23/h3-6,11-12H,7-10,13H2,1-2H3,(H,24,25,28)
Canonical SMILES:
CC1=CC(=NC(=C1)NC(=S)N2CCN(CC2)CC3=CC=C(C=C3)C(F)(F)F)C
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


AR12463
(CAS: 100557-04-8)

AR12456 is a trapidil derivative. It protects against serum hyperlipidemia in guinea pigs. It has a strong antilipidemic action in guinea pigs fed a cholesterol...

CAS 5072-26-4 Buthionine Sulphoximine

Buthionine Sulphoximine
(CAS: 5072-26-4)

Buthionine Sulphoximine, also known as NSC-326231, is a potent and specific inhibitor of alpha-glutamyl cysteine synthetase.

CAS 120138-50-3 Quinupristin

Quinupristin
(CAS: 120138-50-3)

Quinupristin is an antibiotic agent and usually used in combination with dalfopristin The trade name is Synercid. It is active against Gram-positive bacteria th...

CAS 38562-01-5 Prostaglandin F2α (tromethamine salt)

Prostaglandin F2α (tromethamine salt)
(CAS: 38562-01-5)

Prostaglandin F2α is a Naturally-occurring prostaglandin and potent vasoconstrictor, exhibiting luteolytic activity.

CAS 481-46-9 Ginkgetin

Ginkgetin
(CAS: 481-46-9)

Ginkgetin is a natural biflavonoid isolated from leaves of Ginkgo biloba L. According to reports, it has anti-inflammatory and anti-cancer effects.

CAS 66-84-2 D-Glucosamine Hydrochloride

D-Glucosamine Hydrochloride
(CAS: 66-84-2)

D-Glucosamine hydrochloride is present in mucopolysaccharides and in polysaccharides found in bacteria, fungi, higher plants has been used as a standard to quan...

GNE-3500
(CAS: 1537859-24-7)

GNE-3500 has been found to be a Retinoic acid receptor-related Orphan receptor C agonist that could be probably significant in studies of some inflammatory dise...

CAS 1203956-47-1 11β-HSD1-IN-1

11β-HSD1-IN-1
(CAS: 1203956-47-1)

11β-HSD1-IN-1 is an inhibitor of 11β-hydroxydehydrogenase 1 (11β-HSD1) (IC50= 52 nM).

CP-432
(CAS: 431990-08-8)

CP-432 is an EP4 prostaglandin agonist , potential useful for the treatment of glaucoma and ocular hypertension.

CAS 211110-63-3 Sobetirome

Sobetirome
(CAS: 211110-63-3)

Sobetirome selectively binds to and activates TRbeta over TRalpha and this receptor selectivity led to the hypothesis that sobetirome would lower cholesterol th...

CEP dipeptide 1
(CAS: 816432-15-2)

CEP dipeptide 1 is a CEP dipeptide which has potent angiogenic activity. It is used as mediators of age-related macular degeneration (AMD).

CAS 518-69-4 Corydaline

Corydaline
(CAS: 518-69-4)

Corydaline, extracted from Corydalis ambigua, is one of the major active constituents in a new prokinetic botanical agent exhibiting the antiacetylcholinesteras...

CK-2289
(CAS: 101183-99-7)

CK-2289 is an type III cyclic 3'5'-adenosine monophosphate phosphodiesterase inhibitor. It may be used in the treatment of congestive heart failure.

CAS 594839-88-0 Tafamidis

Tafamidis
(CAS: 594839-88-0)

Tafamidis is a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade. It is a drug for the amelioration of transthyretin-relat...

CAS 1582-09-8 Trifluralin

Trifluralin
(CAS: 1582-09-8)

Trifluralinis a pre-emergence herbicide, because it causes absence of microtubule which leads to prevents the completion of plant cell division. However, it doe...

CAS 2646-71-1 NADPH tetrasodium salt

NADPH tetrasodium salt
(CAS: 2646-71-1)

NADPH tetrasodium salt is an ubiquitous coenzyme that acts as an electron donor in various biological reactions.

CAS 591778-70-0 CP640186 HCl

CP640186 HCl
(CAS: 591778-70-0)

CP-640186 is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respec...

CAS 102841-42-9 Mulberroside A

Mulberroside A
(CAS: 102841-42-9)

Mulberroside A, extracted from the root bark of white mulberry, could reduce P-gp expression and function being along with the activation of PKC and NF-κB. It h...

CAS 97145-43-2 Kallikrein Inhibitor

Kallikrein Inhibitor
(CAS: 97145-43-2)

Kallikrein Inhibitor, a synthetic peptide, is a serine protease inhibitor that inhibits kallikrein and plasmin, and can attenuate breast cancer cell invasion.

Elamipretide
(CAS: 736992-21-5)

Elamipretide is a cardiolipin peroxidase inhibitor and mitochondria-targeting peptide under the development of Stealth BioTherapeutics. It can Improve left Vent...

Chemical Structure

CAS 1916571-90-8 NCT-503

Quick Inquiry

Verification code

Featured Items