NCB-0846 - CAS 1792999-26-8
Catalog number: B0084-007723
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C21H21N5O2
Molecular Weight:
375.42
COA:
Inquire
Targets:
Wnt
Description:
NCB-0846 is an orally available, first-in-class TNIK inhibitor (IC50= 21 nM) and shows marked anti-tumour and anti-CSC activities.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-007723 300 mg $688 In stock
Bulk Inquiry
Brife Description:
An orally available TNIK inhibitor (IC50= 21 nM)
Synonyms:
NCB-0846; NCB 0846; NCB0846; 4-[2-(3H-benzimidazol-5-ylamino)quinazolin-8-yl]oxycyclohexan-1-ol
Solubility:
DMSO: ≥ 30 mg/mL
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
Inquire
Boiling Point:
726.2±70.0 ℃ at 760 Torr
Density:
1.415±0.06 g/cm3
InChIKey:
FYWRWBSYRGSWIQ-UHFFFAOYSA-N
InChI:
1S/C21H21N5O2/c27-15-5-7-16(8-6-15)28-19-3-1-2-13-11-22-21(26-20(13)19)25-14-4-9-17-18(10-14)24-12-23-17/h1-4,9-12,15-16,27H,5-8H2,(H,23,24)(H,22,25,26)
Canonical SMILES:
C1CC(CCC1O)OC2=CC=CC3=CN=C(N=C32)NC4=CC5=C(C=C4)N=CN5
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Wnt Products


CAS 853220-52-7 BML-284

BML-284
(CAS: 853220-52-7)

BML-284 is potent selective, and cell-permeable Wnt signaling activator that does not inhibit GSK-3β (IC50 > 60 µM). It appears to mimic the effects of a Wnt li...

CAS 664969-54-4 LF3

LF3
(CAS: 664969-54-4)

LF3 is a potent inhibitor of Wnt/β-catenin signaling (IC50= 1.65 μM), but does not interfere with E-cadherin/β-catenin-mediated cell-cell adhesion.antitumor act...

CAS 909089-13-0 SKL 2001

SKL 2001
(CAS: 909089-13-0)

SKL 2001 is a Wnt/β-catenin signaling pathway agonist that modulates the differentiation of mesenchumal stem cells. It upregulates the β-catenin responsive tran...

CAS 847591-62-2 PRI-724

PRI-724
(CAS: 847591-62-2)

PRI-724 is a potent, specific inhibitor of the canonical Wnt signaling pathway in cancer stem cells with potential antineoplastic activity. Wnt signaling pathwa...

CAS 577696-37-8 Cardionogen 1

Cardionogen 1
(CAS: 577696-37-8)

Cardionogen 1 has been found to be a Wnt signaling modulator that could affect cardiomyocyte generation.

CAS 1467013-03-3 Adavivint

Adavivint
(CAS: 1467013-03-3)

Adavivint is a Wnt pathway inhibitor.

CCT251545
(CAS: 1661839-45-7)

CCT251545, a small molecule inhibitor of WNT signaling with oral activity, can be used as a selective chemical probe that exhibits >100-fold selectivity for the...

CAS 1127442-87-8 exo-IWR 1

exo-IWR 1
(CAS: 1127442-87-8)

exo-IWR 1, the enantiomer of IWR-1 and the diastereomer of IWR-1-endo, is a potent SAR anticancer Wnt response inhibitor, which is a kind of small secreted prot...

Chemical Structure

CAS 1792999-26-8 NCB-0846

Quick Inquiry

Verification code

Featured Items