|Description||Navuridine is a RNA-directed DNA polymerase inhibitor under the development of Bayer HealthCare Pharmaceuticals. But research for the teatment of HIV infections was discontinued.|
|Solubility||Soluble in DMSO|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Current Developer||Bayer HealthCare Pharmaceuticals|
This active molecular has a Benzothiopyrano-indazole structure and the benzothiopyranoindazoles are potent inhibitors of nucleic acid synthesis, reducing both D...
Pyridostatin TFA salt
Pyridostatin stabilizes G-quadruplexes (G4s) in cells and elicits a DNA damage response by causing the formation of DNA double strand breaks (DSB).
CP 80080, a quinolinecarboxylic acid derivative, has been found to influencing DNA cleavage slightly and could probably be used in th anticancer studies.
Hydroxyurea is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
CP 115953 is a Type II DNA topoisomerase inhibitor originated by Pfizer. CP 115953 inhibits topoisomerase II activity via an interaction with the enzyme and not...
Temozolomide acid is an active metabolite of temozolomide(T017775) with anticancer activity in vitro. Temozolomide is an alkylating agent used as a treatment of...
Lobucavir is a RNA-directed DNA polymerase inhibitor originated by Bristol-Myers Squibb as a nucleoside analog. Treatment for Cytomegalovirus infections, Hepati...
This active molecular is a DNA-directed DNA polymerase inhibitor potentially originated by Medivir AB. Omaciclovir can be selectively phosphorylated by viral th...
SCR7 successfully inhibits cell proliferation of MCF7, A549, HeLa, T47D, A2780, HT1080, and Nalm6 with IC50 of 40, 34, 44, 8.5, 120, 10, and 50 μM, respectively...
TH287 hydrochloride, with potent anti-cancer property, is a novel inhibitor of the MTH1 protein which is required for cancer cell survival and is overexpressed ...
Datelliptium chloride, derived from ellipticine, is a DNA-intercalating agent with good activity in murine tumor models over a broad range of doses.
CP-74667 is a Type II DNA topoisomerase inhibitor originated by Pfizer. No development was reported for Bacterial infections in USA.
L189 is a DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 μM respectively) that blocks DNA binding. L189 inhibits base excision repair (BER) and ...
YU238259 is a novel inhibitor of homology-dependent DNA repair (HDR) while not inhibiting non-homologous end-joining in cell-based GFP reporter assays. Treatmen...
TH588 hydrochloride, with potent anti-cancer property, is a novel inhibitor that highly selectively targets MTH1 protein (IC50= 5 nM) which is required for canc...
LMI070, also called as NVS-SM1, is a selective, high plasma exposure and orally active modulator of SMN2 splicing which demonstrates robust activity across dise...
This active molecular is a topoisomerase I inhibitor originated by ShangHai HaiHe Pharmaceutical. Simmitecan is also a promising water-soluble prodrug of chimmi...
L67 is a DNA Ligase Inhibitor. L67 inhibited DNA ligases I and III. L67 is a simple competitive inhibitor with respect to nicked DNA. L67 inhibits DNA ligases I...
BAY 56-3722, a water-soluble camptothecin derivative, is a DNA-Intercalating drug that stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-d...
BMH-21 is a potent small molecule DNA intercalator. BMH-21 binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription.