|Description||Navuridine is a RNA-directed DNA polymerase inhibitor under the development of Bayer HealthCare Pharmaceuticals. But research for the teatment of HIV infections was discontinued.|
|Solubility||Soluble in DMSO|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Current Developer||Bayer HealthCare Pharmaceuticals|
Datelliptium chloride, derived from ellipticine, is a DNA-intercalating agent with good activity in murine tumor models over a broad range of doses.
Dezaguanine is a new antipurine antimetabolite. Dezaguanine is a DNA synthesis inhibitor. It has significant activity against transplantable rodent solid tumors...
TH588 selectively kill U2OS and other cancer cell lines with less toxic to several primary or immortalized cells.
CP-74667 is a Type II DNA topoisomerase inhibitor originated by Pfizer. No development was reported for Bacterial infections in USA.
BMH-21 is a potent small molecule DNA intercalator. BMH-21 binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription.
CP 80080, a quinolinecarboxylic acid derivative, has been found to influencing DNA cleavage slightly and could probably be used in th anticancer studies.
The hydrochloride salt form of Tinostamustine, a benzimidazol derivative, has been found to be a HDAC inhibitor and could probably be effective against sorts of...
TH287 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 0.8 nM.
This active molecular is a DNA-directed DNA polymerase inhibitor potentially originated by Medivir AB. Omaciclovir can be selectively phosphorylated by viral th...
BAY 56-3722, a water-soluble camptothecin derivative, is a DNA-Intercalating drug that stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-d...
SCR7 pyrazine is a DNA Ligase IV inhibitor. SCR7 pyrazine has been shown to potentiate CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency in vitro u...
Pyridostatin TFA salt
Pyridostatin stabilizes G-quadruplexes (G4s) in cells and elicits a DNA damage response by causing the formation of DNA double strand breaks (DSB).
CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM, has no effect on Pol II, and possesses 2...
Lobucavir is a RNA-directed DNA polymerase inhibitor originated by Bristol-Myers Squibb as a nucleoside analog. Treatment for Cytomegalovirus infections, Hepati...
BRD7116, a bis-aryl sufone with cell-non-autonomous anti-leukemia activity, competitively binds to bacterial DNA gyrase and is an inhibitor of leukemia stem cel...
Nitracrine, an acridine derivative, inhibits RNA synthesis and is an antitumor drug that has been used clinically for several years.
Navuridine is a RNA-directed DNA polymerase inhibitor under the development of Bayer HealthCare Pharmaceuticals. But research for the teatment of HIV infections...
MS-073 is a Type II DNA topoisomerase inhibitor under the development of Nihon Schering. MS-073 can overcome MDR in vitro and in vivo compare to verapamil. MS-0...
TH287 hydrochloride, with potent anti-cancer property, is a novel inhibitor of the MTH1 protein which is required for cancer cell survival and is overexpressed ...
Amenamevir is a DNA helicase-primase inhibitors. It has anti-HSV activity against herpes simplex keratitis. In Mar 2016, Mahuro completed a phase III trial in H...