Nav1.7-IN-2 - CAS 1332295-35-8
Catalog number: 1332295-35-8
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C22H22FN5O2
Molecular Weight:
407.44
COA:
Inquire
Targets:
Sodium Channel
Description:
Nav1.7-IN-2, a voltage-gated sodium channels, could be probably effective in chronic pain therapy. IC50: 80 nM.
Publictions citing BOC Sciences Products
  • >> More
Purity:
98%
Appearance:
Powder
Synonyms:
Benzamide, 3-[[4-[3-(4-fluoro-2-methylphenoxy)-1-azetidinyl]-2-pyrimidinyl]amino]-N-methyl-
Solubility:
10 mM in DMSO
Storage:
-20ºC Freeze
MSDS:
Inquire
Application:
Nav1.7-IN-2 is a voltage-gated sodium channels and could be probably effective in chronic pain therapy.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
InChIKey:
MFAKJGXMORSMIX-UHFFFAOYSA-N
InChI:
InChI=1S/C22H22FN5O2/c1-14-10-16(23)6-7-19(14)30-18-12-28(13-18)20-8-9-25-22(27-20)26-17-5-3-4-15(11-17)21(29)24-2/h3-11,18H,12-13H2,1-2H3,(H,24,29)(H,25,26,27)
Canonical SMILES:
CC1=C(C=CC(=C1)F)OC2CN(C2)C3=NC(=NC=C3)NC4=CC=CC(=C4)C(=O)NC
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Sodium Channel Products


CAS 5875-06-9 Proxymetacaine hydrochloride

Proxymetacaine hydrochloride
(CAS: 5875-06-9)

Proparacaine Hydrochloride is a topical ophthalmic anesthetic, acting by inhibiting the voltage-gated sodium channels. IC50(ED50): 3.4 mM.

CAS 1234365-97-9 Tenapanor HCl

Tenapanor HCl
(CAS: 1234365-97-9)

Tenapanor, also known as AZD-1722 and RDX 5791, is a first-in-class, small-molecule inhibitor of the gastrointestinal sodium/hydrogen exchanger NHE3. Tenapanor ...

CAS 42971-09-5 Vinpocetine

Vinpocetine
(CAS: 42971-09-5)

Vinpocetine is a Phosphodiesterase inhibitor and selective for PDE1. It also blocks voltage-gated Na+ channels.

VX-150

VX-150 is a NaV1.8 blocker which is currently in a phase II clinical trial for the treatment of patients with acute pain. Study shows that VX-150 significantly ...

CAS 396-01-0 Triamterene

Triamterene
(CAS: 396-01-0)

Triamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner with IC50 of 4.5 μM.

CAS 130800-90-7 Sipatrigine

Sipatrigine
(CAS: 130800-90-7)

Sipatrigine is a blocker of voltage-dependent sodium channels (NaV) and a glutamate release inhibitor. Sipatrigine exhibits neuroprotective activity in rat mode...

CAS 1432913-36-4 GX-674

GX-674
(CAS: 1432913-36-4)

GX-674 is a Nav1.7 antagonist in the aryl sulfonamide class with higher selectivity for Nav1.7 (IC50= 0.1nM) over other Nav subtypes. Nav1.7 is commonly express...

CAS 1744-22-5 Riluzole

Riluzole
(CAS: 1744-22-5)

Riluzole is a drug used to treat amyotrophic lateral sclerosis.

CAS 526224-73-7 Huwentoxin IV

Huwentoxin IV
(CAS: 526224-73-7)

Huwentoxin IV is a selective NaV1.7 channel blocker with preference for neuronal NaV1.7, 1.2 and 1.3 (IC50 = 26, 150 and 338 nM, respectively). Huwentoxin IV in...

AM-36
(CAS: 199467-52-2)

AM-36 is a potent blocker of batrachotoxinin (BTX)-sensitive Na+ channel binding in rat brain homogenates with an IC50 of 0.28 microM. As a unique neuroprotecti...

ProTx III

ProTx III, isolated from the venom of the Peruvian green-velvet tarantula Thrixopelma pruriens, is a potent Nav1.7 blocker (IC50 = 2.5 nM) and also inhibits Nav...

CAS 4368-28-9 Tetrodotoxin

Tetrodotoxin
(CAS: 4368-28-9)

Tetrodotoxin, frequently abbreviated as TTX, is a potent neurotoxin. Its name derives from Tetraodontiformes, an order that includes pufferfish, porcupinefish, ...

CAS 5369-00-6 QX 222

QX 222
(CAS: 5369-00-6)

QX 222, a quaternary ammonium derivative of lidocaine, is a sodium channel blocker.

CAS 1430806-04-4 PF 05089771

PF 05089771
(CAS: 1430806-04-4)

PF 05089771 is a selective and potent inhibitor of the human voltage-gated sodium ion channel Nav1.7 with an IC50 value of 11 nM. It exhibits selectivity for Na...

CAS 925463-91-8 Jingzhaotoxin III

Jingzhaotoxin III
(CAS: 925463-91-8)

Jingzhaotoxin III is a selective blocker of NaV1.5 channels with IC50 value of 348 nM. It is selective for NaV1.5 channels and shows no effect on other isoforms...

GS967
(CAS: 1262618-39-2)

GS967, also known as GS-458967, is a highly selective late sodium channel current blocker. The selective inhibition of late INa with GS967 can exert antiarrhyth...

T-1095
(CAS: 209746-59-8)

T-1095, with potential antidiabetic effect, is an inhibitor of renal Na+-glucose cotransporters that may provide a novel way to treating diabetes.

OD1

OD1 is a rat Nav1.7, human Nav1.4 and rat Nav1.6 channel activator. It exhibits minimal activation at mammalian Nav1.2, Nav1.3 and Nav1.5. OD1 can induce sponta...

CAS 1198160-14-3 NAV 26

NAV 26
(CAS: 1198160-14-3)

NAV 26 is a Nav1.7 channel blocker with IC50 value of 370 nM. It can reduce nociceptive behavior in rat models of pain.

CAS 22059-60-5 Disopyramide phosphate

Disopyramide phosphate
(CAS: 22059-60-5)

Disopyramide phosphate is an oral antiarrhythmic agent for the treatment of cardiac arrhythmias. Disopyramide is a sodium channel blocker and therefore classifi...

Quick Inquiry

Verification code

Featured Items