Nateglinide - CAS 105816-04-4
Catalog number: 105816-04-4
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C19H27NO3
Molecular Weight:
317.42
COA:
Inquire
Targets:
Others
Description:
Nateglinide(Starlix) is an insulin secretagog agent that lowers blood glucose levels by stimulating insulin secretion from the pancreas. It achieves this by closing ATP-dependent potassium channels in the membrane of the β cells.
Purity:
>98%
Synonyms:
DJN 608; DJN-608l; DJN608; Nateglinide; Fastic; Starlix; A-4166; A 4166; A4166
MSDS:
Inquire
InChIKey:
OELFLUMRDSZNSF-OFLPRAFFSA-N
InChI:
InChI=1S/C19H27NO3/c1-13(2)15-8-10-16(11-9-15)18(21)20-17(19(22)23)12-14-6-4-3-5-7-14/h3-7,13,15-17H,8-12H2,1-2H3,(H,20,21)(H,22,23)/t15?,16?,17-/m1/s1
Canonical SMILES:
CC(C)C1CCC(CC1)C(=O)NC(CC2=CC=CC=C2)C(=O)O
1.Effects of nateglinide and rosiglitazone on pancreatic alpha- and beta-cells, GLP-1 secretion and inflammatory markers in patients with type 2 diabetes: randomized crossover clinical study.
Tostes GC1, Cunha MR1, Fukui RT1, Correia MR1, Rocha DM1, Dos Santos RF1, da Silva ME1. Diabetol Metab Syndr. 2016 Jan 4;8:1. doi: 10.1186/s13098-015-0120-6. eCollection 2016.
BACKGROUND: To compare the effects of nateglinide and rosiglitazone on inflammatory markers, GLP-1 levels and metabolic profile in patients with type 2 diabetes (DM2).
2.Comparison of sitagliptin with nateglinide on postprandial glucose and related hormones in drug-naïve Japanese patients with type 2 diabetes mellitus: A pilot study.
Tanimoto M1, Kanazawa A2, Hirose T1, Yoshihara T1, Kobayashi-Kimura S1, Nakanishi R1, Tosaka Y1, Sasaki-Omote R1, Kudo-Fujimaki K1, Komiya K1, Ikeda F1, Someya Y1, Mita T1, Fujitani Y1, Watada H3. J Diabetes Investig. 2015 Sep;6(5):560-6. doi: 10.1111/jdi.12338. Epub 2015 Mar 15.
AIMS/INTRODUCTION: Dipeptidyl peptidase-4 inhibitors and glinides are effective in reducing postprandial hyperglycemia. However, little information is available on the comparative effects of the two drugs on the levels of postprandial glucose. The aim of the present study was to compare the effects of sitagliptin and nateglinide on meal tolerance tests in drug-naïve patients with type 2 diabetes mellitus.
3.Preparation of polyclonal antibodies for nateglinide (NTG) and development of a sensitive chemiluminescent immunoassay to detect NTG in tablets and serum.
Zheng L1, Wang J1, Zhang J2, Song Z1, Dong Y1, Wang Y1, Tong Z2, Deng C3, Yin Y1, Meng M4, Xi R1. Talanta. 2016 Jan 1;146:483-9. doi: 10.1016/j.talanta.2015.09.008. Epub 2015 Sep 9.
In this study, we prepared polyclonal antibodies against anti-diabetic drug nateglinide (NTG), and established a sensitive chemiluminescent immunoassay (CLIA) to detect NTG in tablets and serum. Two kinds of immunogens were synthesized using ethylcarbodiimide (EDC)/hydroxysuccinimide (NHS) and carbonyldiimidazole (CDI)/4-dimethylaminopyridine (DMAP) as coupling reagents respectively. When activated by EDC/NHS, more molecules of NTG coupled with carrier protein in immunogens. A horseradish peroxidase (HRP)-luminol-H2O2 system with p-iodophenol enhancement was applied in the CLIA analysis. The antibodies in EDC/NHS group showed higher titer, sensitivity and wider detection linear range than those in CDI/DMAP group, and were chosen for next studies. The developed CLIA assay exhibited good selectivity towards NTG among structually similar analogs. The method could detect as low as 0.35 ng mL(-1) NTG in buffer, 2.1 ng mL(-1) NTG in serum and 0.
4.Development and in vitro/in vivo evaluation of controlled release provesicles of a nateglinide-maltodextrin complex.
Sahoo RK1, Biswas N1, Guha A1, Sahoo N1, Kuotsu K1. Acta Pharm Sin B. 2014 Oct;4(5):408-16. doi: 10.1016/j.apsb.2014.08.001. Epub 2014 Sep 4.
The aim of this study was to characterize the provesicle formulation of nateglinide (NTG) to facilitate the development of a novel controlled release system of NTG with improved efficacy and oral bioavailability compared to the currently marketed NTG formulation (Glinate™ 60). NTG provesicles were prepared by a slurry method using the non-ionic surfactant, Span 60 (SP), and cholesterol (CH) as vesicle forming agents and maltodextrin as a coated carrier. Multilamellar niosomes with narrow size distribution were shown to be successfully prepared by means of dynamic laser scattering (DLS) and field emission scanning electron microscopy (FESEM). The absence of drug-excipient interactions was confirmed by Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC) and X-ray diffraction (XRD) studies. In vitro release of NTG in different dissolution media was improved compared to pure drug. A goat intestinal permeation study revealed that the provesicular formulation (F4) with an SP:CH ratio of 5:5 gave higher cumulative amount of drug permeated at 48 h compared to Glinate™ 60 and control.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 138736-73-9 HAMNO

HAMNO
(CAS: 138736-73-9)

HAMNO is a novel protein interaction inhibitor of replication protein A (RPA), which is involved in the ATR/Chk1 pathway. HAMNO acts by binding to the N-termina...

CAS 808-26-4 Sancycline

Sancycline
(CAS: 808-26-4)

Sancycline is a tetracycline bacteriostatic antibiotic which can bind to the Tet repressor protein (TetR). It is a rare semi-synthetic tetracycline prepared by ...

CAS 36861-47-9 4-Methylbenzylidene camphor

4-Methylbenzylidene camphor
(CAS: 36861-47-9)

4-Methylbenzylidene camphor (4-MBC) is an organic camphor derivative that is used in the cosmetic industry for its ability to protect the skin against UV, speci...

CAS 345909-26-4 Taurocholic Acid Sodium Salt Hydrate

Taurocholic Acid Sodium Salt Hydrate
(CAS: 345909-26-4)

Choleretic; Its sodium salt is a bile salt formed in the liver by conjugation of cholic acid with taurine that is involved in the emulsification of lipids used ...

CAS 256447-08-2 Ac2-12

Ac2-12
(CAS: 256447-08-2)

Ac2-12 is an annexin/lipocortin 1-mimetic peptide that inhibits leukocyte extravasation. It promotes detachment of neutrophils from activated mesenteric endothe...

CAS 104206-65-7 Nitisinone

Nitisinone
(CAS: 104206-65-7)

Nitisinone(SC0735) is an inhibitor of the enzyme 4-hydroxyphenylpyruvate dioxygenase.

RUSKI-201 dihydrochloride

RUSKI-201 dihydrochloride is a sonic hedgehog acyltransferase (HHAT) inhibitor (IC50 = 0.20 μM) devoid of off-target cytotoxicity, and quantitative whole-proteo...

CAS 370586-05-3 CID-797718

CID-797718
(CAS: 370586-05-3)

A novel protein kinase D inhibitor that causes potent arrest in prostate cancer cell growth and motility.

Chemical Structure

CAS 105816-04-4 Nateglinide

Quick Inquiry

Verification code

Featured Items