Naringin - CAS 10236-47-2
Catalog number: B0084-310696
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
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Cytochrome P450
Naringin inhibits hepatic P-glycoprotein (P-gp) and some drug-metabolizing cytochrome P450 enzymes, including CYP3A4 and CYP1A2, which may result in drug-drug interactions.
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B0084-310696 250 g $149 In stock
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1.Protective effect of Naringin on experimental hindlimb ischemia/reperfusion injury in rats.
Gürsul C1, Ekinci Akdemir FN2, Akkoyun T3, Can İ4, Gül M5, Gülçin İ6,7. J Enzyme Inhib Med Chem. 2016 Apr 7:1-6. [Epub ahead of print]
This study was designed to investigate the antioxidant effects of Naringin, in ischemia/reperfusion (I/R)-induced skeletal muscle injury in rats. The rats were randomly allocated into three groups including control, I/R and I/R + Naringin groups. Muscle tissues of I/R groups revealed significantly higher antioxidant enzyme activities, and increased levels of malondialdehyde, as specific a marker of the lipid peroxidation and tissue damage, compared to the control group (p < 0.05). Levels of these parameters in muscle revealed significant reductions in the I/R + Naringin group compared to the I/R group (p < 0.05). Histopathological examination of ischemia muscles in the I/R group showed significant degeneration and inflammation compared to the control group, whereas ischemic muscles of Naringin-administered group showed significant reduction in degeneration and inflammation compared to the I/R group (p < 0.05). We suggest that the protective effect of Naringin may reduce the I/R injury in cases of extremity injuries with acute vascular complications, extremity surgery with prolonged tourniquet application.
2.NEU3 inhibitory effect of naringin suppresses cancer cell growth by attenuation of EGFR signaling through GM3 ganglioside accumulation.
Yoshinaga A1, Kajiya N1, Oishi K1, Kamada Y1, Ikeda A1, Chigwechokha PK2, Kibe T3, Kishida M3, Kishida S3, Komatsu M2, Shiozaki K4. Eur J Pharmacol. 2016 Apr 19. pii: S0014-2999(16)30249-7. doi: 10.1016/j.ejphar.2016.04.035. [Epub ahead of print]
Naringin, which is one of the flavonoids contained in citrus fruits, is well known to possess various healthy functions to humans. It has been reported that naringin suppresses cancer cell growth in vitro and in vivo, although the underlying mechanisms are not fully understood. Recently, the roles of glycoconjugates, such as gangliosides, in cancer cells have been focused because of their regulatory effects of malignant phenotypes. Here, to clarify the roles of naringin in the negative-regulation of cancer cell growth, the alteration of glycoconjugates induced by naringin exposure and its significance on cell signaling were investigated. Human cancer cells, HeLa and A549, were exposed to various concentrations of naringin. Naringin treatment induced the suppression of cell growth toward HeLa and A549 cells accompanied with an increase of apoptotic cells. In naringin-exposed cells, GM3 ganglioside was drastically increased compared to the GM3 content prior to the treatment.
3.Ameliorative effect of naringin in acetaminophen-induced hepatic and renal toxicity in laboratory rats: role of FXR and KIM-1.
Adil M1, Kandhare AD1, Ghosh P1, Venkata S1, Raygude KS1, Bodhankar SL1. Ren Fail. 2016 Apr 6:1-14. [Epub ahead of print]
CONTEXT: Acetaminophen (APAP) is an analgesic and antipyretic agent commonly known agent to cause hepatic and renal toxicity at a higher dose. Naringin, a bioflavonoid possesses multiple pharmacological properties such as antioxidant, anti-inflammatory, analgesic and anti-hyperlipidemic activity.
4.In vitro effects of the citrus flavonoids diosmin, naringenin and naringin on the hepatic drug-metabolizing CYP3A enzyme in human, pig, mouse and fish.
Burkina V1, Zlabek V2, Halsne R3, Ropstad E4, Zamaratskaia G5. Biochem Pharmacol. 2016 Apr 20. pii: S0006-2952(16)30065-X. doi: 10.1016/j.bcp.2016.04.011. [Epub ahead of print]
Flavonoids are known to have effects on cytochrome P450 enzymatic activity. However, little effort has been made to examine species differences and the relevance of studies on mammalian and fish microsomes so that extrapolations can be made to humans. Therefore, the effects of several naturally occurring flavonoids on the activity of CYP3A-dependent 7-benzyloxy- 4-trifluoromethylcoumarinO-debenzylase (BFCOD) were evaluated in human, pig, mouse, and juvenile rainbow trout sources of hepatic microsomes. Each was exposed to three concentrations (1, 10, and 100 μM) diosmin, naringin, and naringenin. Naringenin competitively inhibited BFCOD activity (Ki values were 24.6 μM in human, 15.6 μM in pig, and19.6 μM in mouse microsomes). In fish, BFCOD activity was inhibited in a noncompetitive manner (Ki = 7 μM). Neither diosmin nor naringenin affected BFCOD activity in hepatic microsomes from the studied model organisms. These results suggest that dietary flavonoids potentially inhibit metabolism of clinical drugs.
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