Naratriptan - CAS 121679-13-8
Catalog number:
121679-13-8
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C17H25N3O2S
Molecular Weight:
335.47
COA:
Inquire
Targets:
5-HT Receptor
Description:
Naratriptan, a 5-HT1B/1D receptor agonist, could be used in the treatment of migraine.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>99%
Appearance:
Powder
Synonyms:
Naratriptan;Naratriptane;N-Methyl-2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethanesulfonamide;N-methyl-2-[3-(1-methyl-4-piperidyl)-1H-indol-5-yl]ethanesulfonamide
Solubility:
DMSO 74 mg/mL (198 mM); Water 22 mg/mL (59 mM)
Storage:
-20ºC Freeze
MSDS:
Inquire
Application:
Naratriptan is a 5-HT1B/1D receptor agonist that could be used in the treatment of migraine.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
Boiling Point:
541.3ºC at 760 mmHg
Density:
1.227g/cm3
InChIKey:
AMKVXSZCKVJAGH-UHFFFAOYSA-N
InChI:
InChI=1S/C17H25N3O2S/c1-18-23(21,22)10-7-13-3-4-17-15(11-13)16(12-19-17)14-5-8-20(2)9-6-14/h3-4,11-12,14,18-19H,5-10H2,1-2H3
Canonical SMILES:
CNS(=O)(=O)CCC1=CC2=C(C=C1)NC=C2C3CCN(CC3)C
1.
2.Reduced efficacy of sumatriptan in migraine with aura vs without aura.
Hansen JM1, Goadsby PJ2, Charles A2. Neurology. 2015 May 5;84(18):1880-5. doi: 10.1212/WNL.0000000000001535. Epub 2015 Apr 3.
OBJECTIVE: To determine whether acute migraine treatment outcome is different in migraine with aura compared with migraine without aura.
3.Acute Migraine Treatment in Adults.
Becker WJ1,2. Headache. 2015 Jun;55(6):778-93. doi: 10.1111/head.12550. Epub 2015 Apr 15.
There are many options for acute migraine attack treatment, but none is ideal for all patients. This study aims to review current medical office-based acute migraine therapy in adults and provides readers with an organized approach to this important facet of migraine treatment. A general literature review includes a review of several recent published guidelines. Acetaminophen, 4 nonsteroidal anti-inflammatory drugs (NSAIDs) (ibuprofen, acetylsalicylic acid [ASA], naproxen sodium, and diclofenac potassium), and 7 triptans (almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, and zolmitriptan) have good evidence for efficacy and form the core of acute migraine treatment. NSAID-triptan combinations, dihydroergotamine, non-opioid combination analgesics (acetaminophen, ASA, and caffeine), and several anti-emetics (metoclopramide, domperidone, and prochlorperazine) are additional evidence-based options. Opioid containing combination analgesics may be helpful in specific patients, but should not be used routinely.
4.Systematic evaluation of matrix effect and cross-talk-free method for simultaneous determination of zolmitriptan and N-desmethyl zolmitriptan in human plasma: a sensitive LC-MS/MS method validation and its application to a clinical pharmacokinetic study.
Patel B1,2, Suhagia BN3, Jangid AG2, Mistri HN2, Desai N1. Biomed Chromatogr. 2016 Mar;30(3):447-58. doi: 10.1002/bmc.3568. Epub 2015 Aug 27.
The objective of the present work was to carry out systematic evaluation to eliminate matrix effect owing to plasma phospholipids as observed during sample preparation and to develop a cross-talk-free sensitive, selective and rapid bioanalytical method for the simultaneous determination of zolmitriptan (ZT) and N-desmethyl zolmitriptan (DZT) in human plasma by liquid chromatography-tandem mass spectrometry using naratriptan as internal standard (IS). The analytes and IS were quantitatively extracted from 200 μL human plasma by solid phase extraction. No cross-talk was found between ZT and DZT having identical product ions. Quantitation was performed on a triple quadrupole mass spectrometer employing electrospray ionization technique, operating in multiple reaction monitoring and positive ion mode. The total chromatographic run time was 2.5 min. The method was fully validated for sensitivity, selectivity, specificity, linearity, accuracy, precision, recovery, matrix effect, dilution integrity and stability studies.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related 5-HT Receptor Products


CAS 112885-42-4 Mosapride Citrate

Mosapride Citrate
(CAS: 112885-42-4)

Mosapride Citrate is a gastroprokinetic agent that acts as a selective 5HT4 agonist.

CAS 367514-88-3 Lurasidone hydrochloride

Lurasidone hydrochloride
(CAS: 367514-88-3)

Lurasidone is an atypical antipsychotic, inhibits Dopamine D2, 5-HT2A, 5-HT7, 5-HT1A and noradrenaline α2C with IC50 of 1.68 nM, 2.03 nM, 0.495 nM, 6.75 nM and ...

LY 344864 racemate
(CAS: 186543-64-6)

LY 344864 racemate is a 5-HT1F receptor agonist.

CAS 115956-13-3 Dalasetron Mesylate

Dalasetron Mesylate
(CAS: 115956-13-3)

The mesylate salt form of Dolasetron which is a pseudopelletierine derivative and could be used to relieve the nausea and vomiting caused by chemotherapy for be...

CAS 115338-32-4 NAN-190 hydrobromide

NAN-190 hydrobromide
(CAS: 115338-32-4)

The hydrobromide salt form of NAN-190 which is an effective antagonist of 5-HT1A serotonin receptor.

CAS 13523-86-9 Pindolol

Pindolol
(CAS: 13523-86-9)

Pindolol, an Indole derivative, could be used in the treatment of hypertension and arrhythmia for acting as a 5-HT1A/1B receptor antagonist. IC50: 33nM(Ki).

CAS 316-81-4 Thioproperazine

Thioproperazine
(CAS: 316-81-4)

Thioproperazine is a potent neuroleptic with antipsychotic properties, for the treatment of all types of acute and chronic schizophrenia, including those which ...

CAS 5189-11-7 Pizotifen Malate

Pizotifen Malate
(CAS: 5189-11-7)

Pizotifen Malate is a benzocycloheptane based agent used for recurrent migraine headaches.

CAS 83366-66-9 NEFAZODONE

NEFAZODONE
(CAS: 83366-66-9)

Nefazodone is a selective serotonin 5-HT2 receptor antagonist. It is an antidepressant under the development of Bristol-Myers Squibb. Its sale was discontinued ...

CAS 111974-69-7 Quetiapine

Quetiapine
(CAS: 111974-69-7)

Quetiapine, an thiazepin-analogue of Clozapine, could be effective in the treatment for schizophrenia and major depressive disorder for behaving as a 5HT-2 and ...

Mirisetron maleate
(CAS: 148611-75-0)

Mirisetron maleate, an oxoquinoline derivative, has been found to be a 5-HT3 receptor antagonist that could probably be effective against anxiety disorders and ...

CAS 179474-85-2 Prucalopride Succinate

Prucalopride Succinate
(CAS: 179474-85-2)

Prucalopride, also known as R-108512, is a selective, high affinity serotonin (5-HT4) receptor agonist with enterokinetic activities. Prucalopride alters coloni...

CAS 85650-56-2 Asenapine

Asenapine
(CAS: 85650-56-2)

Asenapine is a high-affinity antagonist of serotonin, norepinephrine, dopamine and histamine receptors, used for the treatment of schizophrenia and acute mania ...

CAS 115956-12-2 Dolasetron

Dolasetron
(CAS: 115956-12-2)

Dolasetron, a pseudopelletierine derivative, is a 5-HT3 receptor antagonist that could be used to relieve the nausea and vomiting caused by chemotherapy.

CAS 866933-46-2 Velusetrag

Velusetrag
(CAS: 866933-46-2)

Velusetrag is a selective, 5-HT4receptor agonist. Phase II clinical trials for the treatment of gastroparesis are on-going. Clnical trials for Alzheimer's disea...

CAS 98206-09-8 Eltoprazine hydrochloride

Eltoprazine hydrochloride
(CAS: 98206-09-8)

Eltoprazine hydrochloride is the hydrochloride form of Eltoprazine which is a serenic or antiaggressive agent. It acts as an agonist at the 5-HT1A and 5-HT1B re...

CAS 109889-09-0 Granisetron

Granisetron
(CAS: 109889-09-0)

Granisetron is an antagonist of serptpmom 5-HT3 receptor and could be used to relieve the nausea and vomiting symptom after receving chemotherapy by decreasing ...

Agomelatine L(+)-Tartaric acid
(CAS: 824393-18-2)

Agomelatine L(+)-Tartaric acid is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor. It is used as an ant...

CAS 186544-26-3 LY 344864

LY 344864
(CAS: 186544-26-3)

LY 344864 is a brain penetrant, full agonist that specifically targets 5-HT1F receptor (pKi = 8.2) with > 80-fold selectivity over other serotonin receptors (Ki...

CAS 269718-84-5 Pardoprunox

Pardoprunox
(CAS: 269718-84-5)

Pardoprunox, also called as SLV308 or DU-126891, is a D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist (IA = 50% and 67%, respectively) and 5-HT1A rec...

Chemical Structure

CAS 121679-13-8 Naratriptan

Quick Inquiry

Verification code

Featured Items