Naproxen - CAS 22204-53-1
Catalog number: B0084-315840
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C14H14O3
Molecular Weight:
230.26
COA:
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Targets:
COX
Description:
(S)-Naproxen is a non-selective COX inhibitor. The IC50 values for human recombinant COX-1 and -2 are 0.6-4.8 µM and 2.0-28.4 µM, respectively. It is an anti-inflammatory agent with analgesic and antipyretic activities, which is commonly used for the treatment of rheumatoid arthritis and gout.
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Catalog Number Size Price Stock Quantity
B0084-315840 50 g $159 In stock
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Brife Description:
COX inhibitor, rheumatoid arthritis and gout
Purity:
>98%
Synonyms:
(S)-6-Methoxy-α-methyl-2-naphthaleneacetic Acid; po-Naproxen; Aproxen; Bonyl; CG 3117; Diocodal; Dysmenalgit; Equiproxen; Floginax; Laraflex; Laser; MNPA; Naixan; Napren; Naprium; Naprius; Naprosyn; Naprosyne; Naproxen; Naprux; Naxen; Nycopren; Panoxen; Prexan; Proxen; Proxine; RS 3540; Reuxen; Veradol; Xenar; Xenar-CR; d-2-(6-Methoxy-2-naphthyl)propionic Acid; d-Naproxen
Solubility:
Water: 15.9 mg/L (at 25 °C)
MSDS:
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Application:
the treatment of rheumatoid arthritis and gout
Melting Point:
153 °C
InChIKey:
CMWTZPSULFXXJA-VIFPVBQESA-N
InChI:
InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)/t9-/m0/s1
Canonical SMILES:
CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O
1.Impact of chirality on the photoinduced charge transfer in linked systems containing naproxen enantiomers.
Khramtsova EA1, Sosnovsky DV, Ageeva AA, Nuin E, Marin ML, Purtov PA, Borisevich SS, Khursan SL, Roth HD, Miranda MA, Plyusnin VF, Leshina TV. Phys Chem Chem Phys. 2016 May 14;18(18):12733-41. doi: 10.1039/c5cp07305g. Epub 2016 Apr 21.
The model reaction of photoinduced donor-acceptor interaction in linked systems (dyads) has been used to study the comparative reactivity of a well-known anti-inflammatory drug, (S)-naproxen (NPX) and its (R)-isomer. (R)- or (S)-NPX in these dyads is linked to (S)-N-methylpyrrolidine (Pyr) using a linear or cyclic amino acid bridge (AA or CyAA), to give (R)-/(S)-NPX-AA-(S)-Pyr flexible and (R)-/(S)-NPX-CyAA-(S)-Pyr rigid dyads. The donor-acceptor interaction is reminiscent of the binding (partial charge transfer, CT) and electron transfer (ET) processes involved in the extensively studied inhibition of the cyclooxygenase enzymes (COXs) by the NPX enantiomers. Besides that, both optical isomers undergo oxidative metabolism by enzymes from the P450 family, which also includes ET. The scheme proposed for the excitation quenching of the (R)- and (S)-NPX excited state in these dyads is based on the joint analysis of the chemically induced dynamic nuclear polarization (CIDNP) and fluorescence data.
2.Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults.
Law S1, Derry S, Moore RA. Cochrane Database Syst Rev. 2016 Apr 20;4:CD008541. doi: 10.1002/14651858.CD008541.pub3.
BACKGROUND: This is an updated version of the original Cochrane review published in October 2013 on 'Sumatriptan plus naproxen for acute migraine attacks in adults'.Migraine is a common disabling condition and a burden for the individual, health services, and society. It affects two to three times more women than men, and is most common in the age range 30 to 50 years. Effective abortive treatments include the triptan and non-steroidal anti-inflammatory classes of drugs. These drugs have different mechanisms of action and combining them may provide better relief. Sumatriptan plus naproxen is now available in combination form for the acute treatment of migraine.
3.Preparation and recrystallization behavior of spray-dried co-amorphous naproxen-indomethacin.
Beyer A1, Radi L2, Grohganz H3, Löbmann K4, Rades T5, Leopold CS6. Eur J Pharm Biopharm. 2016 Apr 26. pii: S0939-6411(16)30143-6. doi: 10.1016/j.ejpb.2016.04.019. [Epub ahead of print]
To improve the dissolution properties and the physical stability of amorphous active pharmaceutical ingredients, small molecule stabilizing agents may be added to prepare co-amorphous systems. The objective of the study was to investigate if spray-drying allows the preparation of co-amorphous drug-drug systems such as naproxen-indomethacin and to examine the influence of the process conditions on the resulting initial sample crystallinity and the recrystallization behavior of the drug(s). For this purpose, the process parameters inlet temperature and pump feed rate were varied according to a 22 factorial design and the obtained samples were analyzed with X-ray powder diffractometry and Fourier-transformed infrared spectroscopy. Evaluation of the data revealed that the preparation of fully amorphous samples could be achieved depending on the process conditions. The resulting recrystallization behavior of the samples, such as the total recrystallization rate, the individual recrystallization rates of naproxen and indomethacin as well as the polymorphic form of indomethacin that was formed were influenced by these process conditions.
4.The Effect of Various Vehicles on the Naproxen Permeability through Rat Skin: A Mechanistic Study by DSC and FT-IR Techniques.
Salimi A1, Hedayatipour N1, Moghimipour E1. Adv Pharm Bull. 2016 Mar;6(1):9-16. doi: 10.15171/apb.2016.003. Epub 2016 Mar 17.
PURPOSE: The purpose of the present investigation was to evaluate the effectiveness of different vehicles on drug permeability and microstructure of intercellular or lipids in SC layer of skin.
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CAS 22204-53-1 Naproxen

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