Naphtho[1,2-b]furan-4-carboxylic acid,5-hydroxy-,methyl ester - CAS 61658-41-1
Catalog number: 61658-41-1
Not Intended for Therapeutic Use. For research use only.
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Furomollugin can be found in the roots of Rubia cordifolia L.
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5-Hydroxynaphtho[1,2-b]furan-4-carboxylic acid methyl ester
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1.Inhibition of hepatitis B surface antigen secretion on human hepatoma cells. Components from Rubia cordifolia.
Ho LK;Don MJ;Chen HC;Yeh SF;Chen JM J Nat Prod. 1996 Mar;59(3):330-3.
The antiviral activity in the roots of Rubia cordifolia was examined, and three naphthohydroquinones, furomollugin (1), mollugin (2), and rubilactone (3), were isolated from it. Compounds 1 and 2 strongly suppressed the secretion of hepatitis B surface antigen (HBsAg), both with IC50 = 2.0 micrograms/mL, in human hepatoma Hep3B cells while having little effect on the viability of the cells. Evaluation of structurally related derivatives of 1 and 2 revealed that a 6-hydroxy group and a pyran or furan ring contribute to this suppressive effect.
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CAS 61658-41-1 Naphtho[1,2-b]furan-4-carboxylic acid,5-hydroxy-,methyl ester

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