Expert nanoparticle surface modification designed to meet your specific research and development needs.
Nanoparticle surface functionalization is a key technology for enhancing the performance of nanomaterials and enabling precise application outcomes. Through the controlled modification of nanoparticle surfaces, properties such as dispersibility, stability, compatibility, and functional specificity can be significantly improved. Leveraging well-established chemical modification platforms and extensive experience in nanomaterial processing, BOC Sciences provides highly customized nanoparticle surface functionalization services to support the efficient advancement of research and industrial development projects.
Nanoparticle functionalization workflow schematicWe offer multidimensional and customizable nanoparticle surface functionalization solutions. All services are individually designed based on nanoparticle type, particle size, and specific application objectives, including but not limited to the following capabilities:
We introduce precisely defined small molecules or reactive functional groups onto nanoparticle surfaces, creating stable anchoring points for subsequent conjugation and multi-level functional expansion.
Surface modification with polymers of controlled molecular weight allows precise control over particle dispersion and interfacial behavior, providing enhanced stability and adaptability to diverse environmental conditions.
Using established conjugation techniques, proteins, enzymes, antibodies, peptides, or nucleic acids can be stably immobilized on nanoparticle surfaces, creating highly specific and function-driven interfaces tailored to your application needs.
For applications requiring selective binding or molecular recognition, we can present specific targeting ligands on the nanoparticle surface, enabling directional interaction with defined structures or environments.
To support detection, tracking, or signal readout, nanoparticles can be functionalized with fluorescent dyes, isotopes, or metallic signal tags, providing clear and reliable reporting capabilities.
Driven by complex application requirements, multiple categories of ligands can be integrated onto a single nanoparticle surface, enabling cooperative functionality and modular surface architectures.
BOC Sciences offers tailored surface modifications to optimize nanoparticle performance across applications. Explore customized functionalization strategies for your research and development needs.
Our nanoparticle surface functionalization services support a wide range of materials, including metals, oxides, semiconductors, polymers, lipids, and carbon-based materials. Particle sizes span from 1 nm to 1000 nm, accommodating diverse research and industrial applications. In terms of geometry, nanoparticles can be spherical, rod-shaped, plate-like, star-shaped, or feature porous structures, such as mesoporous silica, providing a versatile platform for surface modification. Additionally, our services can handle various dispersion media, including aqueous systems, organic phases (e.g., oleic acid/oleylamine), and powder forms, ensuring optimal surface functionalization across different application environments.
| Nanoparticle Category | Functionalization We Offer |
| Gold Nanoparticles | Thiol-PEG modification, Antibody/peptide conjugation, Silica coating |
| Silver Nanoparticles | Thiol/PEG stabilization, Biomolecule (chitosan) coating |
| Magnetic Nanoparticles | Silica/polymer coating, Carboxyl/amino functionalization, DMSA ligand exchange |
| Silica Nanoparticles | Silanization (amino, carboxyl), Stimuli-responsive "molecular gate" modification |
| Quantum Dots | Ligand exchange, Amphiphilic polymer coating, Silica encapsulation |
| Carbon Nanotubes/Graphene | Carboxylation, π–π stacking modification, Biomolecule adsorption |
| Carbon Quantum Dots | Direct functional group conjugation (using surface –COOH/–NH2) |
| Polymeric Particles | Terminal group functionalization, Surface carboxyl/amino modification, Lipid coating |
| Lipid Nanoparticles | Lipid insertion (DSPE-PEG ligands), Surface adsorption/conjugation |
| Multifunctional Core-Shell Particles | Shell silanization, Multifunctional covalent conjugation |
BOC Sciences provides systematic nanoparticle surface functionalization solutions to address key technical bottlenecks in both research and industrial applications, precisely tackling:
✔ Physical Stability Limitations
By optimizing nanoparticle surface modifications, we significantly improve dispersibility and prevent aggregation under high-salt or complex environments, ensuring long-term particle stability.
✔ Functionalization Challenges
For inert surfaces or particles lacking reactive groups, we design efficient conjugation strategies that enable reliable binding of biomolecules or targeting ligands.
✔ Biological and Interface Compatibility Issues
Utilizing customized surface treatments, we enhance compatibility with target biological systems, improving cellular uptake efficiency and extending circulation time in vivo.
✔ Batch Variability and Quality Control
Through rigorous quality management systems, we ensure consistent surface modification across batches, minimizing variability and improving reproducibility.
✔ Scale-Up Obstacles
We support seamless translation from laboratory-scale protocols to industrial production, delivering stable and reproducible outputs suitable for large-scale applications.
✔ Complex Modification Design Challenges
Leveraging tailored multi-functional surface modification solutions, we meet diverse research and industrial application needs, enabling high-performance nanoparticle functionality.
Engage with clients to understand nanoparticle type, size, and application objectives, and develop a customized surface functionalization plan.
Execute the designed modification under strict quality control, including functional group introduction, polymer coating, or biomolecule conjugation.
Systematically analyze the modified nanoparticles for dispersibility, stability, surface functionality, and targeting capability, and optimize the process as needed.
Provide comprehensive experimental data and material information, along with professional technical support for subsequent applications, scale-up, or further development.
Client: A biotechnology company developing anticancer drug carriers
Requirement: The client aimed to develop nanoparticles capable of precise delivery of anticancer drugs for in vitro and animal model studies of cervical cancer. Their original PLGA (poly(lactic-co-glycolic acid)) nanoparticles loaded with Paclitaxel tended to aggregate, with uneven surface ligand distribution, resulting in unstable drug loading and insufficient targeting efficiency. They needed a solution to enhance stability, achieve uniform functionalization, and implement FRα (folate receptor alpha) ligand modification.
Solution: BOC Sciences applied chemical conjugation to uniformly graft FRα targeting ligands onto the surface of PLGA nanoparticles, combined with surface charge optimization to improve dispersion and stability. Ligand density was precisely controlled to ensure reproducibility. The functionalized nanoparticles were validated via particle size distribution, Zeta potential, and drug release profiles.
Outcome: The functionalized nanoparticles demonstrated high targeting efficiency and stable drug release in vitro, providing the client with reproducible and scalable experimental materials, significantly improving R&D efficiency and accelerating candidate drug screening.
Client: A biotechnology company specializing in nucleic acid therapeutics
Requirement: The client sought to develop lipid nanoparticles (LNPs) for hepatocyte-specific delivery of siRNA to silence target genes. Their original LNPs suffered from excessive plasma protein adsorption, limited stability, and insufficient targeting in vitro and in vivo, resulting in low effective payload delivery and poor reproducibility. They required a surface functionalization solution to enhance LNP stability and reduce non-specific adsorption.
Solution: BOC Sciences implemented a multi-functional surface modification strategy by conjugating hepatocyte-specific GalNAc ligands to the LNP surface for ASGPR receptor-mediated targeting, incorporating biodegradable lipid anchors to enhance in vivo stability, and designing pH-responsive release structures to optimize siRNA release kinetics.
Outcome: The functionalized LNPs demonstrated high targeting specificity, enhanced stability, and controllable drug release. The client confirmed significantly improved targeting efficiency in hepatocytes, noting that the method was directly applicable to animal studies, significantly improving siRNA therapeutic R&D efficiency.
Extensive Nanomaterial Handling ExperienceWith years of expertise in nanoparticle surface modification, we are proficient in diverse nanomaterials and functionalization technologies, delivering efficient solutions for both research and industrial applications.
Highly Customized Functionalization StrategiesSurface modification strategies are precisely designed based on nanoparticle type, size, application goals, and specific client requirements, enabling controlled and tunable surface properties.
Strict Quality Control and ReproducibilityStandardized workflows and robust quality control systems ensure batch-to-batch consistency and reproducibility, meeting the reliability requirements of research and industrial use.
Multifunctional and High-Performance Surface DesignSupports the integration of targeting, labeling, responsiveness, and stability features, enabling advanced surface designs for applications such as delivery systems, imaging, and sensing.
Comprehensive Technical Support and Application GuidanceEnd-to-end technical support is provided from strategy development and implementation to characterization and scale-up, helping clients efficiently advance their projects.
Nanoparticle surface functionalization significantly enhances particle stability, dispersibility, and targeting ability. By introducing specific chemical groups, particles can selectively bind molecules or respond to environmental cues. BOC Sciences offers diverse functionalization strategies, including covalent and non-covalent approaches, providing customized solutions to improve nanoparticle performance in materials science, drug delivery research, and bio-detection applications.
BOC Sciences supports various nanoparticle functionalization types, such as PEGylation, amino/carboxyl modification, fluorescent labeling, and metal surface modification. These approaches improve dispersibility, biocompatibility, or enable controlled binding. We optimize functionalization strategies based on material type and application goals to ensure uniform and reproducible surface modification, meeting different research and industrial development needs.
Surface modification can greatly enhance nanoparticle stability in solution, reducing aggregation or sedimentation. By selecting appropriate chemical groups and controlling modification density, BOC Sciences fine-tunes particle charge and hydrophilic/hydrophobic properties, ensuring long-term stability across various solvents or complex systems, supporting reliable performance in experiments and applications.
Targeted functionalization introduces specific ligands, antibodies, or small molecules onto nanoparticle surfaces, enabling selective binding to target molecules. BOC Sciences provides tailored conjugation strategies, optimizing chemical linkage and spatial configuration to achieve efficient binding and functional display, supporting applications in bio-detection, targeted delivery, or molecular capture with precise control over nanoparticle performance.
Surface functionalization greatly broadens nanoparticle applications, including catalytic supports, imaging probes, sensor development, and material modification. BOC Sciences delivers highly customizable functionalization solutions, enabling multi-functional integration while preserving core particle properties, supporting rapid adaptation in material research, analytical detection, and advanced scientific projects, enhancing nanoparticle versatility across multiple use scenarios.
