Precision Surface Engineering for Advanced Drug Delivery, Diagnostics & Material Innovation
Nanoparticle functionalization is a critical step that unlocks the full potential of nanomaterials—transforming them from passive carriers into targeted, stable, and application-ready platforms. Whether you are developing next-generation therapeutics, building high-performance diagnostic assays, or engineering innovative materials, our end-to-end Nanoparticle Functionalization Services ensure unmatched control, reproducibility, and performance. We partner with pharmaceutical companies, biotech innovators, research institutes, and materials developers to accelerate R&D and streamline product development with customized, scalable, and compliant nano-surface engineering solutions.
Difference between unfunctionalized nanoparticles and functionalized nanoparticlesNanoparticle surface functionalization is a critical step in developing high-performance nanomedicine, drug delivery systems, and diagnostic nanoprobes. By combining advanced bioconjugation chemistry, polymer coatings, and analytical characterization, functionalized nanoparticles provide superior stability, targeting efficiency, and reproducibility—key factors valued by pharmaceutical manufacturers, biotech companies, and research laboratories worldwide.
Functionalized nanoparticles enable precise targeting through antibodies, peptides, ligands, or nucleic acids.
This improves therapeutic index, reduces off-target effects, and increases the efficiency of drug or gene delivery systems.
Surface modification—such as PEGylation or polymer coating—prevents aggregation and increases stability in serum, buffers, and complex biological fluids.
Better stability leads to predictable behavior in vivo and supports nanoparticle development.
Functional coatings minimize immune recognition and protein adsorption, extending nanoparticle half-life in systemic administration.
This is critical for nanomedicine applications where controlled pharmacokinetics influence therapeutic outcomes.
Defined surface chemistry ensures consistent drug binding capacity and tailored release kinetics.
This allows pharmaceutical teams to develop more predictable, scalable, and application-specific nanoparticle formulations.
Bioconjugated nanoparticles enhance signal intensity and specificity in immunoassays, lateral-flow tests, and molecular diagnostics.
Higher assay reliability directly impacts sensitivity, product consistency, and regulatory acceptance.
Functional groups such as —COOH, —NH₂, —SH, or click-ready chemistries allow precise engineering of charge, reactivity, and ligand orientation.
This ensures compatibility with diverse bioconjugation workflows and advanced nanofabrication processes.
We offer a wide range of chemical, biological, and polymer-based functionalization strategies, optimized for different nanoparticle platforms and application scenarios.
We provide precise chemical modification strategies that enable nanoparticles to bind selectively with biomolecules, polymers, or other engineered surfaces.
Our chemical functionalization services include:
These modifications enhance reactivity, tunability, colloidal stability, and allow consistent downstream bioconjugation for drug delivery, biosensing, or materials engineering.
We specialize in methods that preserve biological activity and ensure predictable molecular orientation.
Our bioconjugation offerings include:
Each biomolecular coupling project includes activity verification and quantification to ensure reproducibility and assay performance.
Our polymer-coating services are designed to improve nanoparticle stability, circulation time, and compatibility with complex environments.
Key offerings include:
These coatings help nanoparticles meet application-specific performance requirements in biological fluids, industrial formulations, or extreme environments.
For advanced applications requiring complex surface structures, we offer multi-layer, multi-functional designs.
Capabilities include:
This service supports innovative product development and allows clients to build next-generation nanoparticle systems with high specificity and performance.
Our services are compatible with a wide variety of nanomaterials, including:
Metal Nanoparticles
Magnetic & Metal Oxide Nanoparticles
Silica & Hybrid Nanoparticles
Polymer Nanoparticles
Carbon-Based Nanomaterials
To ensure each batch of functionalized nanoparticles meets the stringent requirements of pharmaceutical, biotechnology, and diagnostics applications, we provide a comprehensive suite of analytical characterization services. Our testing workflows validate particle size, surface chemistry, morphology, biomolecule conjugation efficiency, and long-term stability—delivering the high level of reproducibility and quality control expected by regulated industries. All characterization data are generated using industry-standard instrumentation and are suitable for internal R&D, regulatory submissions, and product development documentation.
| Category | Techniques / Methods | Purpose / What It Confirms | Typical Industry Standard |
| Particle Size & Stability | DLS (Dynamic Light Scattering) | Hydrodynamic diameter, size distribution, polydispersity index (PDI) | Required for drug delivery, diagnostics, and regulatory submission |
| Zeta Potential | Surface charge & colloidal stability prediction | Common QC for all functionalized nanoparticles | |
| Surface Chemistry Verification | FTIR Spectroscopy | Functional group confirmation & coating verification | Used by nano-CDMOs for batch release |
| XPS (X-ray Photoelectron Spectroscopy) | Elemental composition & surface chemical states | Industry standard for surface-modified metals, silica, polymers | |
| TGA (Thermogravimetric Analysis) | Organic coating thickness & ligand density estimation | Key for PEGylated or polymer-coated particles | |
| Morphology & Structure | TEM (Transmission Electron Microscopy) | Core size, shape uniformity, morphology | Baseline requirement for metal & silica nanoparticles |
| SEM (Scanning Electron Microscopy) | Surface topology & structural consistency | Preferred for polymer, silica, and inorganic materials | |
| Optical Properties | UV–Vis Spectroscopy | Particle concentration, bonding shifts, optical stability | Essential for gold/silver nanoparticles, assay components |
| Fluorescence Spectroscopy | Signal intensity, emission profile, dye loading | Standard for fluorophore-labeled, or diagnostic probes | |
| Bioconjugation & Functionalization Efficiency | Protein/antibody quantification assays (BCA, ELISA, absorbance at 280 nm) | Conjugation density, biomolecule activity retention | Required for immunoassay & targeted delivery nanoparticles |
| DNA/RNA loading quantification | Oligonucleotide coupling efficiency | Used by nucleic-acid-based therapeutic developers | |
| Colloidal Performance & Stability | Salt/serum stability testing | Predicts behavior in biological fluids | Expected QC for preclinical applications |
| Accelerated aging & shelf-life studies | Long-term storage stability | Standard for commercial diagnostic nanoparticles | |
| Purity & Contaminant Analysis | Endotoxin (LAL) testing | Ensures suitability for biological applications | Required by pharma & biotech partners |
| Residual solvent/chemical analysis | Confirms removal of reaction reagents | Standard when coating or ligand attachment involves organic chemistry |
We analyze your application, nanoparticle type, and performance goals.
Custom functionalization route tailored to biological, chemical, or material constraints.
Small-batch synthesis with iterative refinement.
From milligram R&D batches to multi-gram or production-scale.
All analytical reports delivered in a ready-to-file format.
We provide consistent, reproducible batch replication to support ongoing production needs for diagnostics, therapeutics, and research products.
Advanced Surface Chemistry ExpertiseDeep experience in chemical and biological functionalization for high-performance nanomaterials.
Pharma-Grade ReproducibilityConsistent, batch-to-batch reliability meeting the demands of drug delivery and diagnostic applications.
Scalable Custom ManufacturingFlexible production from milligram R&D batches to multi-gram and pilot-scale supply.
Comprehensive Analytical CharacterizationFull QC profiling including DLS, zeta potential, TEM/SEM, FTIR, XPS, and conjugation efficiency analysis.
Application-Ready FunctionalizationTailored surface engineering optimized for targeted delivery, bioassays, sensing, and material innovation.
Regulatory-Friendly DocumentationDetailed technical reports suitable for internal compliance and regulatory submissions.
Fast Lead Times & Dedicated Technical SupportRapid turnaround with expert guidance from project planning to final delivery.
We support a wide range of materials, including gold and silver nanoparticles, magnetic nanoparticles, silica and mesoporous silica, polymer nanoparticles (e.g., PLGA, polystyrene), quantum dots, and carbon-based nanomaterials.
We can introduce —COOH, —NH2, —SH, —OH, aldehyde, azide/alkyne (click chemistry) and conjugate antibodies, peptides, proteins, DNA/RNA, aptamers, enzymes, PEG polymers, and custom ligands.
Yes. All functionalization workflows are fully customizable, including ligand density, surface chemistry, coating type, and bioconjugation strategy.
Absolutely. Our team analyzes your application (drug delivery, diagnostics, sensing, materials engineering) and recommends the most suitable functionalization and coating approach.
Typical QC includes DLS, zeta potential, UV-Vis, fluorescence measurements, FTIR, XPS, TEM/SEM images, and conjugation efficiency quantification. Additional tests (e.g., ICP-MS, HPLC, endotoxin) are available upon request.
Yes. We provide PEGylation using a wide range of PEG linkers (PEG-COOH, PEG-NH₂, PEG-SH, custom MW) to improve biocompatibility, circulation time, and colloidal stability.
Yes. We use optimized bioconjugation methods that preserve biological activity, and we can perform activity verification assays when needed.
Whether you're developing targeted drug delivery systems, designing diagnostic probes, or optimizing nanomaterial performance, our team of specialists is ready to support your project with scientifically rigorous and application-specific nanoparticle functionalization services. We offer customized chemistry strategies, scalable manufacturing pathways, and comprehensive analytical characterization to ensure your nanoparticles meet the highest industry standards. Contact our technical team to discuss your requirements, request a feasibility assessment, or receive a tailored quotation for your project.
