We offer specialized professional expertise in lipid nanoparticle (LNP) synthesis for research institutions globally and pharmaceutical companies to aid their R&D efforts in drug delivery systems for gene therapy and vaccine development. Our services cover all stages from initial research through large-scale production to provide tailored lipid nanoparticle products that meet our clients' diverse needs.
The ability of lipid nanoparticles to effectively encapsulate mRNA and other therapeutic agents enables targeted delivery while simultaneously improving drug stability and therapeutic effectiveness. Lipid nanoparticles protect unstable mRNA drugs from degradation inside the body and enable their precise delivery to target cells which creates therapeutic effects.
Our delivery vectors ensure safe and effective transport of CRISPR-based gene editing tools to drive forward gene therapy advancements. Lipid nanoparticles serve as effective carriers for gene editing tools by enabling cellular entry, promoting gene editing processes while minimizing immune reactions and cytotoxic effects.
Our work focuses on enhancing the stability and immunogenicity profiles of emerging vaccines specifically mRNA vaccines to bolster their development. Lipid nanoparticles shield mRNA vaccines from degradation while boosting expression in immune cells which leads to enhanced immune responses.
We produce lipid nanoparticles with different properties and functionalities according to client specifications that include cationic lipids, neutral lipids, and PEGylated lipids. Through advanced synthesis technologies we manufacture high-quality lipid nanoparticles which match the specific lipid types and ratios requested by clients. The synthesis process for cationic lipid nanoparticles can be optimized to enhance their binding ability to nucleic acids.
We use lipid nanoparticles to encapsulate client-supplied active ingredients including drug molecules and nucleic acids to enhance delivery efficiency and targeting precision. Our team uses multiple encapsulation methods while choosing the optimal technique based on drug properties and delivery specifications. To improve encapsulation efficiency for insoluble drugs we utilize methods including co-solubilization together with high-pressure homogenization.
Our team develops lipid nanoparticle formulations that match particular drugs and therapeutic demands to achieve better stability and bioavailability. We create optimized formulation parameters such as lipid nanoparticle composition, particle size, and surface charge by evaluating drug characteristics alongside therapeutic targets and administration routes. Within tumor-targeting lipid nanoparticle development we add specific targeting molecules which assist in recognizing and binding tumor cells.
Our comprehensive analytical and testing services cover particle size assessment, PDI measurements, encapsulation efficiency testing, and stability analysis to maintain product quality standards. Our laboratory utilizes sophisticated testing instruments including dynamic light scattering (DLS) and high-performance liquid chromatography (HPLC) to achieve accurate analysis of lipid nanoparticle characteristics. Dynamic light scattering (DLS) enables researchers to determine particle size distribution and maintain nanoparticles within the target nanometer range for successful delivery.
Our team provides complete technical assistance along with quality management at every stage from laboratory-scale experiments to pilot-scale testing and large-scale manufacturing. Our process scale-up expertise allows us to convert laboratory-optimized formulations into efficient large-scale production workflows. We maintain strict adherence to GMP standards during production to achieve consistent and stable product quality.
Clients contact us to provide detailed project requirements, and we assess the feasibility of the project and offer professional advice.
Both parties sign the service contract, and clients prepare and provide necessary data such as drug molecules, nucleic acid sequences, etc.
Based on client requirements, we develop lipid nanoparticle formulations and conduct initial synthesis, providing samples for testing.
Based on testing results, we optimize the formulation and process to ensure that the product meets quality standards and functional requirements.
After optimization, large-scale production is carried out with strict quality control, ensuring on-time delivery of the finished product.
Professional Technical TeamOur team includes experienced scientists and engineers who specialize in lipid nanoparticle synthesis and application technologies.
Advanced Equipment and FacilitiesOur facilities use state-of-the-art international instruments for synthesis, testing and production to deliver efficient and accurate production outcomes and services.
Strict Quality ControlOur quality control process includes rigorous testing for each product batch in accordance with international standards to maintain consistent and reliable performance.
Customized ServicesOur flexible and personalized solutions change with specific client demands and support different stages of research and development.
Fast Delivery CycleDrug Delivery: Lipid nanoparticles enable targeted drug delivery to particular tissues and cells which results in improved drug stability and bioavailability. Lipid nanoparticles serve as delivery vehicles for anticancer medications such as doxorubicin and paclitaxel which results in enhanced therapeutic effectiveness and decreased side effects.
Gene Therapy: Lipid nanoparticles serve as carriers to transport genetic material into cells for therapeutic gene therapy applications. Lipid nanoparticles function as vital delivery systems for mRNA vaccines and CRISPR-Cas9 gene editing techniques.
Vaccine Development: Lipid nanoparticles serve as essential components in vaccines by safeguarding antigens and strengthening the body's immune reaction. Lipid nanoparticles function as delivery systems for mRNA in COVID-19 vaccines to maintain stability and achieve efficient expression within the body.
Disease Diagnosis: Medical imaging and early disease identification benefit from lipid nanoparticles which function as contrast agents and diagnostic markers.
Active Ingredient Carriers: LNPs serve as delivery vehicles for cosmetic active ingredients which enhance both stability and permeability of these substances. Lipid nanoparticles enable the delivery of antioxidants such as vitamin C and vitamin E which increases their absorption and effectiveness when applied to the skin.
Skin Moisturization and Repair: Lipid nanoparticles resemble the skin's natural lipid configuration which leads to better moisture retention while strengthening skin barrier operations and encouraging skin repair and renewal.
Pesticide Carriers: LNPs serve as pesticide carriers which boost their stability and controlled release capabilities while minimizing environmental loss and non-target organism toxicity. Lipid nanoparticles serve as delivery systems for herbicides and insecticides which enhance absorption rates and utilization efficiency within plant systems.
Plant Growth Regulators: Lipid nanoparticles serve as delivery systems for plant growth regulators that boost plant development and enhance agricultural output.
Catalyst Carriers: Within chemical industry applications, LNPs function as catalyst carriers that enhance catalyst performance and reaction selectivity while promoting chemical processes.
Materials Science: Lipid nanoparticles provide the means to create new nanomaterials like nanocomposites and nanosensors for diverse applications.
Our services are applicable in various fields such as drug delivery, gene therapy, and vaccine development, and can encapsulate mRNA, siRNA, small molecule drugs, and more.
We strictly control key indicators such as particle size (typically between 20-200nm), PDI (as low as 0.15), and encapsulation efficiency (greater than 90%).
Yes, we provide full technical support from formulation development to process scale-up to ensure the smooth progression of client projects.
We ensure stability through formulation and process optimization, combined with advanced testing methods to guarantee product stability during storage and use.
