The success of therapeutic applications in gene therapy depends directly on the efficiency and safety of gene delivery as it remains a vital aspect of the field's growth. Our specialized team utilized their extensive research background and practical expertise to create advanced lipid nanoparticles (LNPs) for gene delivery services. Our team delivers fully customized solutions throughout early research investigations and preclinical development stages up to clinical trial sample preparation to assist your gene therapy projects in tackling difficult challenges.
Tailored Formulation Design: We specialize in customizing lipid compositions to match your specific gene delivery needs. Our formulations include ionizable lipids, neutral helper lipids, cholesterol, and PEGylated lipids, ensuring the best lipid nanoparticle (LNP) formulation for your project.
Precise Size Control: Using advanced synthesis techniques and equipment, we ensure precise control over the size of the LNPs, ranging from 50 to 200 nm, tailored to meet the requirements of various gene delivery applications.
Scalable Production: Whether you're at the small-scale lab stage or need large-scale industrial production, we provide reliable and consistent production capabilities to supply high-quality LNPs for both early-stage research and commercial applications.
Targeted Delivery: We conduct thorough analyses of gene therapy targets and modify LNP surfaces with specific targeting molecules like antibodies or peptides. This approach enables targeted delivery to specific cells or tissues, improving both therapeutic efficacy and safety.
Optimization of Delivery Mechanisms: By enhancing our understanding of cellular uptake and endosomal escape processes, we optimize LNP structures and compositions to boost intracellular release efficiency, maximizing gene expression and therapeutic functions.
Compatibility with Various Nucleic Acids: We design gene delivery carriers suitable for different nucleic acid types, including mRNA, siRNA, and plasmid DNA, supporting a wide range of gene therapy strategies.
Cell-Level Validation: Our team conducts extensive gene delivery experiments using lipid nanoparticles across various cell lines and primary cells. We use methods like fluorescence labeling and reporter gene assays to assess delivery efficiency, cellular uptake, and intracellular release dynamics.
Animal Model Evaluation: We perform in vivo gene delivery studies in different disease models to evaluate gene expression, therapeutic effects, and potential toxicity, providing valuable insights into LNP performance and helping to accelerate preclinical development.
Formulation Refinement: We optimize LNP formulations by carefully selecting excipients and preparation methods that improve stability, bioavailability, and administration routes, enhancing the overall product performance.
Environmental Stability Testing: Our stability assessments simulate various storage and transportation conditions, such as temperature, humidity, and light exposure, ensuring optimal storage conditions and extending the shelf life of the product.
Lyophilization Development: We specialize in lyophilization techniques to preserve LNP stability in solid form, making long-term storage and transport easier and more cost-effective.
Contact our professional team to discuss your project requirements and objectives in detail.
We will develop a personalized lipid nanoparticle (LNP) gene delivery plan tailored to your needs.
LNP synthesis and gene delivery carrier construction will be carried out according to the proposed plan.
Delivery experiments will be conducted on cell and animal models to evaluate delivery efficiency and safety.
Experimental data will be analyzed, and a detailed report with recommendations will be provided.
Based on experimental results, we assist in formulation optimization and preclinical development efforts.
The platform uses microfluidic mixing systems together with thin-film hydration equipment and ethanol injection systems to manufacture tiny (~100 nm), stable, and uniform lipid nanoparticles for effective nucleic acid encapsulation.
The characterization platform incorporates nanoparticle size and zeta potential analyzers alongside capillary electrophoresis systems and microplate readers to evaluate the physicochemical traits and functionality of lipid nanoparticles.
The platform improves lipid composition using ionizable lipids and adjusts parameters such as the N/P ratio to maintain stability and high delivery efficiency in different pH environments.
Expert R&D TeamComposed of experienced scientists specializing in lipid nanoparticle technology and gene delivery.
State-of-the-Art Equipment & Technology PlatformEquipped with internationally advanced nanoparticle synthesis, characterization, and analysis tools to ensure high-quality service output.
Stringent Quality Control SystemEvery step, from raw material procurement to final product delivery, undergoes rigorous quality testing to ensure consistency and reliability.
Fast Turnaround TimeAn optimized service workflow and highly efficient team collaboration enable us to rapidly deliver the LNP products and services you need.
Advancing the safe and efficient delivery of therapeutic genes to treat genetic disorders and other diseases.
Enhancing the stability, delivery, and immune response of mRNA vaccines for infectious diseases and cancer immunotherapy.
Enabling precise delivery of siRNA and miRNA for gene silencing therapies targeting a wide range of diseases.
Optimizing targeted gene delivery for cancer treatments, including gene editing and immune modulation, to improve therapeutic outcomes.
Providing a safer alternative to viral vectors, reducing the risk of immune responses while ensuring effective gene delivery.
Supporting next-generation vaccine platforms, including DNA and mRNA vaccines, by improving the delivery of genetic material to target cells.
Enhancing gene delivery techniques to support advancements in stem cell therapies and regenerative medicine.
Facilitating the targeted delivery of genes and proteins to promote tissue regeneration and repair, opening new possibilities for advanced therapies.
Lipid nanoparticles (LNPs) protect nucleic acids from degradation in bodily fluids by encapsulating them within a lipid-based structure. Once administered, LNPs interact with cell membranes and enter cells via endocytosis. Inside the cell, they release their cargo, enabling gene expression or regulation for therapeutic effects.
Selecting the right lipid components depends on factors like charge properties, biocompatibility, and delivery efficiency. Ionizable cationic lipids, for example, help form stable complexes with nucleic acids in acidic environments while minimizing cytotoxicity at physiological pH. The choice of helper lipids, cholesterol, and PEGylated lipids also depends on the target tissue and delivery route.
Yes, LNP size plays a crucial role in gene delivery. Smaller nanoparticles (typically 50-100 nm) tend to be more efficiently taken up by cells and can evade immune clearance more effectively, leading to improved gene delivery performance.
Our primary focus is on providing LNPs for research and preclinical applications. However, if you require GMP-grade products, we can support process development and production planning tailored to your specific needs.
We use a variety of in vitro and in vivo evaluation methods, including fluorescence-based cellular uptake assays, reporter gene expression analysis, cytotoxicity tests, pharmacokinetic studies, and tissue distribution analysis in animal models. These comprehensive assessments ensure accurate data on delivery efficiency and safety.
