Lipid nanoparticle (LNP) technology stands out as a primary method for improving both drug stability and delivery efficiency within drug delivery applications. Our LNP drug delivery services provide complete solutions to pharmaceutical companies and research institutions through drug loading techniques and formulation development alongside process optimization and analytical testing as well as preclinical research.
We offer services which tackle these challenges through enhanced drug stability and precision delivery while overcoming biological barriers. Our company delivers specialized solutions for mRNA, siRNA, or small molecule loading into LNPs and optimal LNP formulation development through our expert team support and advanced technology with rigorous quality control.
Drug instability and degradation in vivo: During the development of drugs like nucleic acid-based biologics degradation within the body reduces therapeutic effectiveness and undermines stability and bioavailability.
Low drug delivery efficiency: Traditional drug delivery systems frequently fail to move drugs effectively to their intended locations which results in uneven distribution and ineffective treatment outcomes.
Poor drug targeting: Side effects in non-target tissues emerge alongside reduced treatment effectiveness in target tissues when drug delivery systems exhibit inconsistent distribution and poor targeting.
Difficulties in formulation development: The process of choosing suitable excipients combined with formulation optimization and preparation method selection presents multifaceted challenges.
High production costs: The high costs of production obstruct the development of wide-scale production and market release for new pharmaceutical products.
Low bioavailability: Therapeutic results can suffer when poorly soluble or large-molecule medications experience inadequate absorption and utilization.
We offer advanced drug loading services for various molecules, including mRNA, siRNA, circular RNA, and small molecules. Using state-of-the-art encapsulation techniques, we ensure drugs are fully protected to prevent degradation during transport. Additionally, we optimize loading conditions based on drug properties and therapeutic needs to enhance stability and bioavailability.
Our team customizes LNP formulations tailored to each drug’s characteristics and therapeutic goals. We consider solubility, stability, and release properties while selecting the most suitable lipids and excipients. Through experimental validation and optimization, we ensure optimal formulation performance. Additionally, we develop targeted and sustained-release formulations to meet diverse therapeutic applications.
Leveraging advanced technologies such as microfluidics, we optimize LNP manufacturing processes to achieve high precision, reproducibility, and scalability. Microfluidics ensures consistent LNP production with improved efficiency and reduced costs, supporting both R&D and large-scale manufacturing. Our optimization process carefully evaluates and adjusts key steps to guarantee stability and reliability.
We employ dynamic light scattering (DLS) for precise measurement of LNP size and distribution, high-performance liquid chromatography (HPLC) and UV-Vis spectrophotometry for encapsulation efficiency and drug content analysis, and transmission electron microscopy (TEM) for morphology assessment-providing a comprehensive evaluation of LNP quality.
We conduct cellular uptake, toxicity, and gene silencing studies in vitro, alongside pharmacodynamic and pharmacokinetic studies in animal models to assess therapeutic efficacy, biodistribution, and safety.
During process development, our team systematically studies key manufacturing parameters, utilizing Design of Experiments (DoE) to optimize conditions for stability and reproducibility. For scale-up, we adapt small-scale processes to industrial production, addressing challenges associated with large-scale manufacturing.
We recognize that each client’s drug development project has unique challenges and requirements. Therefore, we offer fully customized LNP drug delivery solutions. From project initiation, we engage in detailed discussions to understand drug properties, therapeutic goals, and desired outcomes, tailoring the most suitable delivery strategy accordingly.
Clients communicate their drug delivery requirements, and we recommend suitable LNP solutions.
Our expert team designs a detailed LNP drug delivery plan and provides a corresponding quote.
Upon agreement on the plan and pricing, both parties sign a contract to officially launch the project.
LNPs are formulated according to the agreed plan, followed by comprehensive quality testing to ensure compliance.
Qualified LNP products are delivered to the client along with technical guidance and after-sales support to facilitate drug development progress.
Ensures the uniformity and stability of lipid nanoparticles (LNPs), enhancing drug encapsulation efficiency and delivery effectiveness.
Designed to identify LNPs with optimal targeting capabilities and delivery performance.
Optimizes LNP performance by designing and synthesizing novel ionizable lipids.
Crucial for achieving precise drug delivery to specific targets.
Expert TeamA team of seasoned professionals with extensive experience and innovation capabilities in LNP drug delivery.
Cutting-Edge TechnologyUtilizes advanced technologies, such as microfluidics, to ensure high-quality and efficient LNP formulation.
Customized SolutionsTailors LNP drug delivery solutions to meet specific client needs across diverse therapeutic applications.
Rigorous Quality ControlImplements a comprehensive quality control system to ensure consistent and reliable product quality.
Rapid DeliveryStreamlines service workflows to expedite LNP formulation and delivery, accelerating drug development timelines.
This delivery system transports mRNA and siRNA as well as antisense oligonucleotides and further compounds to improve gene therapy and immunotherapy techniques.
Precise gene modifications become possible through the integration of CRISPR with other gene editing technologies.
Improves both drug stability and bioavailability to broaden therapeutic uses.
The application of LNPs for vaccines shows great potential demonstrated through their use in mRNA vaccines.
LNPs can be used for the delivery of various drugs, including mRNA, siRNA, circular RNA, and certain small molecules. They are particularly effective for nucleic acid drug delivery, offering protection against degradation and ensuring efficient delivery.
LNPs are biocompatible and safe as drug delivery carriers. Their components are metabolized and cleared from the body. Through formulation and process optimization, potential toxicity and immunogenicity can be minimized, ensuring safe drug delivery.
Yes, we provide customized LNP solutions tailored to the specific characteristics of the drug, therapeutic goals, and delivery requirements. Our expert team will develop the most suitable LNP drug delivery strategy for your needs.
