BOC Sciences exists to deliver outstanding lipid nanoparticle encapsulation solutions for scientific research projects and commercial applications. Our skilled team uses advanced technology and accurate equipment to effectively capture active ingredients inside lipid nanoparticles which guarantees high encapsulation efficiency and consistent particle size with outstanding stability. Our lipid nanoparticle encapsulation solutions can be customized for drug delivery systems and cosmetic active ingredient carriers as well as biotechnological material development to meet your specific requirements which leads to breakthrough innovations and quality advancements while unlocking nanotechnology's immense potential.
mRNA Encapsulation: Encapsulating mRNA molecules in lipid nanoparticles to protect them from degradation in the body, improving stability, transfection efficiency, and gene expression. This service is applicable for mRNA vaccines and gene therapy.
siRNA Encapsulation: Encapsulating siRNA for efficient RNA interference (RNAi) silencing effects. This service is applied in gene function studies and disease treatments, including cancer and viral infections, specifically inhibiting the expression of pathogenic genes.
Plasmid DNA Encapsulation: Encapsulating plasmid DNA in lipid nanoparticles to enhance transfection efficiency and gene expression levels. This service is used in gene therapy, genetic research, and vector delivery in gene editing technologies.
Other Nucleic Acid Encapsulation: Includes the encapsulation of circular RNA, saRNA, and other nucleic acid molecules to meet various research and clinical application needs.
Standard Formulation Application: We provide lipid nanoparticle encapsulation services for common standard formulations such as SM102, ALC-0315, and MC3, ensuring stable encapsulation and excellent biocompatibility.
Customized Formulation Development: We develop personalized lipid nanoparticle formulations based on specific client needs, such as targeting specific tissues or cells or improving delivery efficiency.
Formulation Optimization: We optimize existing lipid nanoparticle formulations by adjusting the ratios of components or selecting more suitable lipid materials to improve encapsulation efficiency, stability, transfection efficiency, or targeting ability.
Antibody Conjugated LNP Preparation: Conjugating tissue-targeting antibodies with lipid nanoparticles, allowing the lipid nanoparticles to specifically target certain tissues or cells, enhancing drug delivery precision and therapeutic efficacy while reducing the impact on non-target tissues.
Personalized Antibody Conjugation Solutions: We offer customized antibody conjugation services based on client targeting needs, selecting the appropriate antibodies and conjugation methods to meet the targeted requirements of different research and applications.
Nucleic Acid Type Customization: In addition to common nucleic acid types, we can encapsulate other special types of nucleic acid molecules according to client requirements.
Service Process Customization: From vector cloning to lipid nanoparticle encapsulation, we provide flexible custom services to meet the schedule and requirements of different projects.
Appearance Inspection: Visual inspection of lipid nanoparticles to check for any visible aggregation, discoloration, or other abnormalities.
Particle Size and Distribution Analysis: Using techniques such as Dynamic Light Scattering (Zetasizer), we accurately measure the particle size and distribution of lipid nanoparticles to ensure uniformity.
Zeta Potential Measurement: Using Dynamic Light Scattering technology to measure the surface charge (Zeta potential) of lipid nanoparticles, we assess their surface charge characteristics and evaluate their stability in physiological environments.
Concentration Measurement: Using methods such as the RiboGreen assay, we accurately determine the nucleic acid concentration within lipid nanoparticles, ensuring encapsulation efficiency and dosage accuracy.
Encapsulation Efficiency Testing: Using appropriate detection methods such as the RiboGreen assay, we precisely assess the encapsulation efficiency of nucleic acids within lipid nanoparticles, typically achieving high levels.
Nucleic Acid Integrity Analysis: Using techniques like Capillary Gel Electrophoresis (CGE), we examine the integrity of nucleic acids after encapsulation to ensure they remain undamaged during the process, preserving their biological activity.
Endotoxin Detection: Using methods such as the Kinetic Chromogenic Assay (KCA), we strictly test the endotoxin content in lipid nanoparticles to ensure that the product meets biological safety requirements.
Sterility Testing: Through microbial load testing and other methods, we conduct sterility testing of lipid nanoparticles to prevent contamination and ensure product quality and safety.
Stability Study: We evaluate the stability of lipid nanoparticles under various conditions, such as different temperatures, pH values, and ionic strengths, to assess their stability during storage and use. This helps provide clients with recommendations on optimal storage and usage conditions.
Small-Scale Production: Providing small-scale lipid nanoparticle encapsulation services for research projects and early-stage drug development, enabling clients to quickly obtain products for preliminary experimentation and evaluation.
Pilot-Scale Production: When a client's project enters the mid-stage research phase and requires larger quantities of product for further research and testing, we offer pilot-scale production services to meet their interim needs.
Large-Scale Production: For clients entering clinical trials or commercialization stages, we provide large-scale lipid nanoparticle encapsulation production services to ensure stable, high-quality product supply that meets market demands.
The client shares their needs, including active ingredients and desired LNP characteristics. Our team provides initial advice and confirms the project's feasibility and plan.
We evaluate the project requirements, including LNP formulation and quality control, then provide a detailed plan and quotation for client approval.
Once both parties agree, we sign a service contract outlining project details, timeline, and delivery standards.
If the client provides the active ingredient, they must supply the required quantity. If we need to source or synthesize it, we handle the process as per the agreement.
We prepare and encapsulate the LNPs by mixing active ingredients and lipid components under controlled conditions, ensuring quality and efficiency.
We conduct thorough testing on the LNPs, including particle size, zeta potential, and encapsulation efficiency, to meet quality standards.
The qualified LNP is delivered with a detailed quality inspection report, stability report (if applicable), and related documentation.
We offer ongoing support to address any issues and assist with further research or LNP optimization, providing additional technical support as needed.
High Encapsulation Efficiency and UniformityWe use advanced technologies like microfluidics to achieve over 90% encapsulation efficiency, with small particle sizes and low PDI, ensuring consistent particle size and stable drug delivery.
Customized ServicesWe offer tailored LNP encapsulation solutions, including different active ingredients, particle sizes, surface modifications, and more, to meet your specific research and application needs.
Professional Technical TeamOur experienced team specializes in nanotechnology and drug delivery, providing expert support in LNP formulation, process optimization, and quality control.
Efficient Delivery and TargetingLNPs protect active ingredients from degradation, extend circulation time, and enable targeted delivery to specific cells or tissues, enhancing drug efficacy and minimizing side effects.
One-Stop ServiceWe offer complete services from ingredient synthesis, LNP formulation, and encapsulation to quality control, stability testing, and scale-up production, saving time and accelerating development.
Strict Quality ControlWe ensure product quality with advanced testing equipment, including dynamic light scattering and electron microscopes, and provide detailed inspection reports.
We can encapsulate a wide variety of substances, including various small molecule drugs, both lipophilic and hydrophilic. Our lipid nanoparticle (LNP) technology can meet the delivery needs of different drugs, helping to improve drug stability and bioavailability. For macromolecular drugs, such as protein drugs and peptide drugs, our LNP technology also provides effective encapsulation solutions, protecting them from enzymatic degradation and ensuring they reach their target sites. In gene therapy, we can efficiently encapsulate gene editing and therapeutic drugs such as mRNA, siRNA, and plasmid DNA, aiding in the delivery of gene drugs and achieving therapeutic goals such as gene expression regulation.
Yes, absolutely. We have a professional R&D team and advanced experimental equipment capable of customizing lipid nanoparticle formulations based on your specific drug properties, therapeutic goals, and administration routes. From selecting the types of lipids, including cationic lipids, neutral auxiliary lipids, cholesterol, and PEGylated lipids, to optimizing their ratios, as well as adding other components, we can fine-tune the formulation to ensure optimal performance of the lipid nanoparticles and meet your unique project requirements.
Yes, we provide detailed quality testing reports for each lipid nanoparticle encapsulation service. The reports will include results for various quality parameters of the lipid nanoparticles, such as particle size and distribution, Zeta potential, drug encapsulation efficiency, drug release curves, as well as relevant biological activity data and stability test results. These reports will help you gain a comprehensive understanding of the product's quality and performance, providing strong support for your research and applications.
