High-precision nanoparticle characterization backed by advanced analytical platforms and regulatory-grade data you can trust.
Nanoparticles play a critical role in modern pharmaceuticals, biologics, diagnostics, and advanced materials. To ensure product safety, stability, and performance, high-resolution characterization is essential. Our state-of-the-art Nanoparticle Analysis & Characterization services provide end-to-end insights into the physical, chemical, and functional attributes of nanoparticles across research, development, and commercial manufacturing workflows. Whether you are developing lipid nanoparticles (LNPs), polymeric carriers, inorganic nanoparticles, virus-like particles (VLPs), drug delivery systems, or nanomaterials, our expert team delivers data you can trust—generated with globally recognized analytical platforms and compliant with international regulatory standards.
Nanoparticles play a critical role in modern pharmaceuticals, drug delivery systems, biologics, diagnostics, and advanced materials. Their performance is highly dependent on precise control of size, morphology, surface chemistry, composition, and stability. Comprehensive characterization ensures that nanoparticle-based products behave predictably in biological systems, maintain safety throughout development, and meet global regulatory expectations. Without accurate analysis, even small formulation variations can result in significant differences in product performance, manufacturability, and long-term stability.
Drug delivery efficiency: Nanoparticle size, surface properties, and structure directly influence biodistribution, targeting, and therapeutic delivery.
Payload stability and release behavior: Detailed analysis helps ensure encapsulated payloads remain stable and release at the intended rate.
Biological interaction and cellular uptake: Surface charge and morphology determine how nanoparticles interact with cells, proteins, and biological fluids.
Batch-to-batch consistency: Quantitative measurements support reproducibility and reduce variability in GMP manufacturing.
Regulatory compliance: High-resolution analytical data is required to satisfy FDA, EMA, and global regulatory guidelines across IND and commercial stages.
Safety and toxicity assessment: Characterization helps detect impurities, aggregation, and structural defects that may trigger adverse biological responses.
We provide a full suite of analytical services designed to give pharmaceutical, biotechnology, and advanced materials teams a complete understanding of their nanoparticle systems. Our capabilities span physical characterization, surface chemistry, morphology, stability, and compositional analysis—supported by industry-leading instrumentation and expert scientific interpretation.
Particle size impacts biodistribution, cellular uptake, immune response, and product stability. We deliver comprehensive measurement strategies using complementary technologies to ensure accuracy across complex nanoparticle systems.
Techniques
What You Get
Surface charge governs nanoparticle stability and interaction with biological systems. Measuring zeta potential provides predictive insight into how your formulation may aggregate, degrade, or behave in physiological conditions.
Capabilities
What You Get
Understanding a nanoparticle's shape, shell integrity, and internal structure is essential for evaluating function and performance—especially for LNPs, liposomes, polymeric micelles, and virus-like particles.
Techniques
What You Get
Nanoparticles often contain multiple materials—lipids, polymers, metals, surfactants, or active ingredients. We identify and quantify these components to ensure purity, performance, and regulatory alignment.
Techniques
What You Get
Precise quantification is critical for pharmaceutical nanoparticles, where efficacy and safety depend on both concentration and purity.
Capabilities
What You Get
Nanoparticles must remain stable throughout manufacturing, storage, and handling. We evaluate stability under real-world and stress conditions to help teams optimize formulation robustness.
Capabilities
What You Get
| Capability Area | Analytical Techniques | Key Deliverables |
| Particle Size & Distribution | DLS, NTA, Laser Diffraction, Cryo-TEM | Hydrodynamic size, PDI, distribution curves, aggregation profile |
| Surface Charge (Zeta Potential) | Electrophoretic Light Scattering | Zeta potential, electrokinetic mobility, stability prediction |
| Morphology & Structure | Cryo-TEM, HRTEM, SEM, AFM | Shape, membrane integrity, crystallinity, structural defects |
| Chemical Composition | EDS, XRD, FTIR, Raman, ICP-MS | Elemental mapping, crystallinity, functional group analysis |
| Concentration & Purity | NTA, UV-Vis, HPLC | Particle count, encapsulation efficiency, purity & residuals |
| Stability Testing | pH/ionic stress, freeze-thaw | Drift in size/charge, aggregation trends, degradation profiles |
High-quality nanoparticle characterization requires not only scientific expertise but also access to advanced analytical instrumentation. Our laboratory is equipped with industry-leading platforms capable of resolving nanoscale physical, chemical, and structural properties with high precision. By combining complementary techniques—such as DLS, NTA, Cryo-TEM, AFM, ICP-MS, and XRD—we ensure that every dataset is accurate, reproducible, and suitable for regulatory submissions. These instruments enable us to support complex formulations, from lipid nanoparticles and polymeric carriers to inorganic nanomaterials and biologics.
| Instrument / Platform | Technique / Purpose | Key Applications |
| Malvern Zetasizer Pro/Ultra | Dynamic Light Scattering (DLS), Zeta Potential | Size, PDI, surface charge, colloidal stability |
| NanoSight NTA System | Nanoparticle Tracking Analysis | Particle size distribution, concentration, aggregation |
| Cryo-TEM (e.g., FEI Talos / JEOL) | High-resolution structural imaging | LNPs, liposomes, VLPs, morphology assessment |
| SEM / TEM | Morphology & surface imaging | Inorganic nanoparticles, polymer structures |
| AFM | 3D surface topography | Nanostructure profiling, roughness, shape |
| XRD | Crystallinity & phase analysis | Metal/oxide nanoparticles, quantum dots |
| ICP-MS / ICP-OES | Trace elemental analysis | Metal content, contamination, impurity analysis |
| FTIR / Raman | Chemical bond & molecular structure | Material identification, functional groups |
| UV-Vis / Fluorescence Spectrometers | Optical characterization | Payload quantification, release profiles |
| HPLC / UPLC | Purity & residual analysis | Drug loading, impurity profiling, degradation |
Define particle type, material, and testing objectives.
Support for liquid, lyophilized, or solid samples.
Performed under quality-controlled environments.
Delivered with high-resolution images, quantitative results, and expert insights.
Method transfer, validation, or ongoing stability studies where needed.
| Sample Type | Required Quantity | Accepted Formats | Notes |
| LNP / Liposome | 0.5–1 mL | Buffer or aqueous suspension | Avoid freeze–thaw cycles |
| Polymeric Nanoparticles | 5–10 mg | Dry powder or suspension | Provide polymer composition |
| Metallic Nanoparticles | 5 mg | Powder or dispersion | Indicate dispersion medium |
| Quantum Dots | 0.5 mL | Suspension | Note fluorophore properties |
| Biological Nanoparticles | 0.5–1 mL | Sterile buffer | Include biosafety information |
Regulatory-Aligned TestingData packages designed to support IND, NDA, and global regulatory filings.
Advanced Analytical PlatformsCryo-TEM, NTA, DLS, XRD, ICP-MS, and more—equivalent to leading global CROs.
Expert Scientific TeamOur specialists have decades of experience in nanoparticle design, biological interactions, and CMC characterization.
Flexible Service ModelsFrom single-test requests to long-term analytical partnerships.
Fast Turnaround TimesAccelerate development without compromising quality.
Nanoparticles are characterized by analyzing size, shape, surface properties, structure, and composition using techniques like electron microscopy, spectroscopy, dynamic light scattering, and X-ray diffraction.
Tools for nanoparticle characterization include scanning and transmission electron microscopy (SEM/TEM), atomic force microscopy (AFM), X-ray diffraction (XRD), and dynamic light scattering (DLS) for size and structural analysis.
X-ray diffraction (XRD) determines the crystalline structure, phase composition, and grain size of nanoparticles by analyzing the diffraction pattern of X-rays interacting with the particle lattice.
Nanoparticles exhibit unique characteristics like high surface-to-volume ratio, tunable optical, electrical, and magnetic properties, and enhanced chemical reactivity, making them versatile for various applications.
BOC Sciences provides comprehensive testing services, including particle size analysis, surface area measurement, zeta potential, XRD, TEM/SEM, and DLS, tailored to research and industrial needs.
BOC Sciences ensures ISO-compliant, high-precision testing for applications in medicine, energy, and electronics, guaranteeing reliable and reproducible results for your nanoparticle development projects.
Accelerate your development with a partner who understands the scientific, technical, and regulatory demands of nanoparticle-enabled products. Whether you are refining an early-stage formulation or preparing a data package for commercial submission, our team provides the analytical depth and operational reliability required for high-stakes pharmaceutical innovation. We work closely with R&D scientists, formulation leaders, CMC teams, and regulatory affairs groups to design customized testing strategies tailored to your nanoparticle system—ensuring you receive clear data, actionable insights, and documentation ready for global regulatory pathways. Contact us today to discuss your project and receive a personalized quotation within one business day.
