BOC Sciences offers a wide range of magnetic lipid nanoparticle (MLNP) products, as well as customized options in various types to meet diverse research and application needs. The products listed below are available for reference. For specific project needs, please provide your specific requirements so that we can precisely tailor the synthesis for you.
| Category Type | Product Category | Price |
| By Application | Drug Delivery MLNPs | Inquiry |
| Magnetic Hyperthermia MLNPs | Inquiry | |
| Imaging MLNPs | Inquiry | |
| Diagnostic MLNPs | Inquiry | |
| Controlled Release MLNPs | Inquiry | |
| By Surface Modification | PEGylated MLNPs | Inquiry |
| Targeted Ligand MLNPs | Inquiry | |
| By Magnetic Particle Location | Solid Magnetic Liposomes (SMLs) | Inquiry |
| Aqueous Magnetic Liposomes (AMLs) | Inquiry |
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Magnetic lipid nanoparticles are a multifunctional composite nanocarrier system. By ingeniously integrating magnetic materials with lipid nanoparticle or liposome structures, they achieve a highly integrated combination of magnetic responsiveness, biocompatibility, and the capacity for drug or gene delivery.
The design of this system aims to leverage external magnetic fields for targeted localization or to enable physical therapeutic functions such as magnetic hyperthermia, while simultaneously utilizing the advantages of lipid carriers to safely and efficiently encapsulate and deliver functional molecules. Consequently, MLNPs are widely recognized as a high-potential, novel tool in biomedical engineering and fundamental research.
The uniqueness of MLNPs arises from the synergistic interaction between their magnetic core and lipid shell. The structural design of the particles directly determines their magnetic responsiveness, stability in biological environments, and interactions with cells.
Magnetic metals are the core functional components that distinguish MLNPs from conventional liposomes.
Their primary functions are reflected in two aspects: magnetic responsiveness and imaging tracking. Magnetic responsiveness enables the nanoparticles to move directionally, accumulate, or generate heat under an external magnetic field. Imaging tracking allows them to serve as contrast agents for magnetic resonance imaging (MRI), facilitating non-invasive monitoring of particle distribution and dynamics in vivo.
In terms of types, superparamagnetic iron oxide nanoparticles (SPIONs) are the most commonly used magnetic materials. They exhibit high saturation magnetization and excellent biocompatibility. When the external magnetic field is removed, their residual magnetism rapidly drops to zero, preventing permanent aggregation of the nanoparticles—a critical factor for biological applications. Other magnetic materials include cobalt ferrite or manganese ferrite, though their use in biomedical research products is relatively limited due to potential toxicity or biocompatibility concerns.
Fig.1 Structural comparison of chi- and lip-magnetic nanoparticle formulations1,2.
The lipid layer provides both biological functionality and structural protection to MLNPs.
The structural functions primarily include cargo encapsulation and biocompatibility. Lipid bilayers or lipid matrix structures are used to encapsulate hydrophilic or hydrophobic active molecules, such as drugs and nucleic acids. As lipids are major components of natural biological membranes, they endow the system with excellent biocompatibility, effectively reducing immune responses.
Stability mechanisms involve both a physical barrier and steric protection. The physical barrier separates the magnetic core from the biological environment, preventing oxidation or degradation of the magnetic core and blocking nonspecific interactions with biological components. Steric protection is achieved by incorporating polyethylene glycol (PEG)-modified lipids into the formulation; the hydrophilic chains form a protective layer on the particle surface, effectively inhibiting aggregation and precipitation in physiological fluids, thereby enhancing dispersive stability.
Table 1. Types and Functions of Magnetic Metals and Lipids in MLNPs.
| Category | Type / Material | Key Features / Notes |
| Magnetic Metals | Superparamagnetic Iron Oxide Nanoparticles | High saturation magnetization; Excellent biocompatibility; Residual magnetism drops to zero after field removal to prevent aggregation; Widely used in biomedical applications |
| Cobalt Ferrite | Strong magnetization; Limited use due to potential toxicity and lower biocompatibility | |
| Manganese Ferrite | Tunable magnetic properties; Less commonly used in biological applications due to biocompatibility concerns | |
| Lipids | Phospholipid bilayers (e.g., phosphatidylcholine, phosphatidylethanolamine) | Encapsulate hydrophilic or hydrophobic molecules; Mimic biological membranes; Reduce immune responses |
| Lipid matrix (solid or hybrid lipids) | Flexible for different payloads; Enhances particle stability | |
| PEGylated lipids (e.g., DSPE-PEG) | Hydrophilic chains form protective layer; Inhibit aggregation and precipitation in physiological fluids; Extend circulation time |
These physicochemical characteristics are key indicators for evaluating the quality of MLNP products and predicting their biological behavior.
Controlling particle size is critical. The ideal size is typically between 50 nm and 200 nm. Particles that are too small may be rapidly cleared by the kidneys, while particles that are too large may be quickly captured by the reticuloendothelial system. Particle size directly affects circulation time in vivo, permeability to target sites, and cellular uptake efficiency.
Surface properties are characterized by zeta potential, which reflects the particle surface charge and is an important parameter for evaluating physical dispersive stability. In applications, surface charge is usually adjusted to near-neutral or moderately negative in physiological conditions by modifying the lipid formulation, such as using neutral or weakly ionizable lipids, to minimize nonspecific adsorption and aggregation.
Dispersibility is fundamental for maintaining system functionality. Good dispersibility ensures particles remain evenly suspended in liquids. In addition to surface charge, the proportion of stabilizers in the lipid formulation is a key technical approach for maintaining long-term dispersive stability. In particular, the appropriate use of PEGylated lipids plays a decisive role in preserving the uniformity and functionality of the system.
To upgrade magnetic lipid nanoparticles from simple magnetic carriers to efficient, intelligent delivery systems, precise chemical modification and functionalization of their surface are essential. These strategies aim to enhance the biological specificity, stability, and cellular uptake efficiency of MLNPs.
Surface modification represents the first step for MLNPs to achieve specific biological functions, primarily by providing defined chemical reaction sites or altering particle behavior in biological environments.
PEGylation
Introduction of Reactive Functional Groups
Targeting Ligand Conjugation
Functional Molecule Conjugation
Dual-Targeting Mechanism: This key approach combines active targeting (ligand-receptor recognition) with passive targeting (particle size and PEG-mediated prolonged circulation). In MLNPs, magnetic targeting via an external magnetic field can also be introduced, creating a triple-targeting mechanism. The integration of these three mechanisms substantially increases particle accumulation in target regions, such as the tumor microenvironment, thereby enhancing therapeutic efficacy.
Environment-Responsive Release Design: Environment-responsive designs use lipids or linkers sensitive to temperature, pH, or redox conditions to achieve controlled, site-specific release. For instance, temperature-sensitive MLNPs can exploit magnetic hyperthermia: an external alternating magnetic field heats the particles, triggering phase transitions in the lipid structure and rapid cargo release. This approach reduces systemic toxicity while improving localized therapeutic effects.
Strategies to Increase Loading Density: Enhancing cargo loading is another critical strategy. Structural optimization, such as adjusting the ratio of magnetic core to lipid or designing core-shell/interlayer structures, maximizes the available cargo space around the magnetic core. Additionally, lipid composition optimization, especially incorporating high-loading-capacity auxiliary lipids, ensures improved drug or nucleic acid encapsulation efficiency while maintaining particle stability.
By integrating these multi-dimensional strategies, both the targeting specificity and loading capacity of MLNPs can be significantly enhanced, providing robust technical support for their application in biomedical research and therapeutics.
Magnetic lipid nanoparticles can leverage both magnetic guidance and surface functionalization to achieve precise drug accumulation in specific tissues or cells. This targeted delivery enhances therapeutic efficacy while minimizing systemic toxicity, offering a highly controlled and efficient approach for localized treatment.
MLNPs serve as effective carriers for DNA, RNA, or siRNA, facilitating cellular uptake and protecting genetic cargo from degradation. Their customizable surface chemistry and biocompatible lipid shell enable efficient intracellular delivery, supporting gene regulation or therapeutic interventions in various biomedical applications.
The magnetic core of MLNPs provides enhanced contrast in MRI, allowing non-invasive visualization of nanoparticle distribution and dynamics in vivo. This imaging capability enables real-time monitoring of delivery, biodistribution, and accumulation, improving both diagnostic accuracy and therapeutic planning.
Under an external alternating magnetic field, MLNPs can generate localized heat, facilitating magnetic hyperthermia treatment of tumors or diseased tissues. This approach can be combined with drug delivery for synergistic therapy, providing a controllable and minimally invasive physical treatment modality.
Surface functionalization combined with magnetic guidance enables efficient accumulation of drugs or functional molecules in specific tissues or cells, enhancing therapeutic efficacy while minimizing systemic side effects.
The lipid shell mimics natural biological membranes, effectively reducing immune responses and ensuring long-term stability in vivo.
MLNPs simultaneously serve as drug carriers, gene delivery vectors, imaging agents, and magnetic hyperthermia platforms, offering a versatile all-in-one solution for research and medical applications.
Environment-responsive designs, such as temperature-, pH-, or redox-sensitive lipids, allow precise temporal and spatial release of cargo, improving treatment accuracy and reducing toxicity.
BOC Sciences uses premium magnetic metals and lipid materials combined with precise nanoparticle fabrication techniques, ensuring uniform particle size, stability, and reproducibility. This high-quality production guarantees consistent performance for various research and biomedical applications.
Their MLNPs support a wide range of applications, including drug delivery, gene transfer, magnetic resonance imaging, and magnetic hyperthermia. This multifunctionality allows researchers to utilize a single platform for diverse experimental and therapeutic needs.
BOC Sciences offers MLNPs with tailored sizes, surface modifications, and functionalization options. This flexibility enables personalized solutions to meet specific experimental requirements, facilitating optimized performance for different research objectives.
The company provides detailed product information, usage guidance, and professional technical support. This helps researchers implement experiments efficiently and reliably, ensuring smooth integration of MLNPs into their scientific workflows.
Magnetic lipid nanoparticles (MLNPs) can be customized, typically ranging from 50–200 nm, balancing optimal circulation time, tissue penetration, and cellular uptake for targeted delivery applications.
MLNPs feature a lipid shell mimicking natural membranes combined with a superparamagnetic iron oxide core, providing excellent biocompatibility and low immunogenicity, suitable for diverse in vitro and in vivo research.
MLNPs can encapsulate hydrophilic and hydrophobic drugs, as well as nucleic acids such as DNA, RNA, or siRNA, with high loading efficiency for versatile drug delivery and gene regulation applications.
MLNPs allow surface functionalization through PEGylation and attachment of reactive groups, enabling conjugation with targeting ligands, cell-penetrating peptides, or environment-responsive molecules for targeted and controlled delivery.
Long-term dispersive stability is achieved via PEGylation and optimized lipid formulations. Storage under low temperature and light-protected conditions preserves particle uniformity and functional performance for extended experimental use.
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