|Description||Naluzotan is a selective 5-HT1A receptor partial agonist under the development of EPIX Pharmaceuticals. It is a serotonergic drug for the treatment of generalized anxiety disorder and major depressive disorder.|
|Solubility||Soluble in DMSO|
|Application||generalized anxiety disorder; major depressive disorder|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Current Developer||EPIX Pharmaceuticals Inc|
GYKI-46903 is a Muscarinic M3 receptor and Serotonin 3 receptor antagonist. In displacement studies, the pIC50 values of GYKI-46903 against [3H]granisetron bind...
Sumatriptan Succinate is a triptan sulfa drug containing a sulfonamide group for the treatment of migraine headaches.
Ziprasidone is a combined 5-HT (serotonin) and dopamine receptor antagonist like other atypical antipsychotic agents. Ziprasidone targets dopamine neurotransmis...
Desmethyl-S 14506 is a precursor for S 14506, a 5-HT1A agonist, which can be used for PET study.
SB 242084 is a brain-penetrant antagonist of 5-HT2C receptor which exhibits 158-fold selectivity for 5-HT2C (pKi= 9.0) over 5-HT2A receptor (pKi= 6.1-6.8) and 1...
TG6-10-1, a potent and selective antagonist for the prostaglandin E2 receptor subtype EP2, has been shown antagonist activity at human EP2 receptor expressed in...
Azasetron HCl is a selective 5-HT3 receptor antagonist with IC50 of 0.33 nM used in the management of nausea and vomiting induced by cancer chemotherapy.
GMC 2-113 is a selective 5-HT1B antagonist.
AVN-492 is a novel highly-potent and highly-selective 5-HT6R antagonist. The affinity of AVN-492 to bind to 5-HT6R (Ki = 91 pM) was more than three orders of ma...
5HT6-ligand-1 is a potent 5-HT6 receptor ligand (Ki= 1.43 nM).
Zatosetron has been identified as a potent, orally available, long-acting, selective 5HT3 receptor antagonist, which is potentially useful in the treatment of c...
LY 344864 racemate
LY 344864 racemate is a 5-HT1F receptor agonist.
Mosapride, a selective agonist of 5-HT4 receptor, could be used as a astroprokinetic agent. It is also found to be a 5-HT3 receptor antagonist.
(±)-MDL 105725 is an active metabolite of MDL 100907, which is a 5-HT2A receptor antagonist.
The salt form of (R)-6-hydroxybuspirone, which is an active metabolite of Buspirone. It is a 5-HT1A partial agonist with higher affinity for 5HT1A receptor comp...
Perphenazine is a typical antipsychotic. a piperazinyl phenothiazine, used to treat psychosis
Trimipramine Maleate is a tricyclic antidepressant for the treatment of depression and depression accompanied by anxiety.
GMC 1-165 is an analogue of clozapine with 5-HT2A/2C and hM1 receptor affinities.
BRL 54443 is a 5-HT1E and 5-HT1F receptor agonist with pKi of 8.7 and 9.25, respectively, with a weak binding affinity for 5-HT1A, 5-HT1B, 5-HT1D receptors.