Naloxegol oxalate - CAS 1354744-91-4
Catalog number:
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Opioid Receptor
Naloxegol oxalate is a CYP3A4 enzyme inhibitor, is a peripherally-selective opioid antagonist, for the treatment of opioid-induced constipation.
Publictions citing BOC Sciences Products
  • >> More
Related CAS:
854601-70-0 (Free base)
Solid powder
(4R,4aS,7S,7aR,12bS)-7-((2,5,8,11,14,17,20-heptaoxadocosan-22-yl)oxy)-3-allyl-1,2,3,4,5,6,7,7a-octahydro-4aH-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol oxalate; NKTR-118; NKTR 118; NKTR118; AZ-13337019; AZ13337019; AZ 13337019; EGylated naloxol; Naloxegol Oxalate; trade names Movantik and Moventig
Quality Standard:
Enterprise Standard
Canonical SMILES:
1.Fatty acyl-gramicidin S derivatives with both high antibiotic activity and low hemolytic activity
Makoto Tamaki, Bioorganic & Medicinal Chemistry Letters 22 (2012) 106-109
A remarkable increase of multidrug-resistant bacteria has become a serious threat to public health threat. The amphiphilic antibiotics that attack bacterial membranes are promising agents for combating bacterial pathogens. Among them, cyclic decapeptide gramicidin S (GS), cyclo(-Val-Orn-Leu-D-Phe-Pro)2, are attractive targets for drug discovery. GS possesses the strong antibiotic activity against Gram-positive bacteria and weak antibiotic activity against Gram-negative bacteria. In addition, no resistance has been found for the antibiotics, because it requires signi?cant alteration of the lipid composition of the cell membrane. However, the high antibacterial potency of GS is intimately associated with high hemolytic activity, preventing the direct use in combating the microbial resistance. The efforts to increase its therapeutic index, namely, minimizing its hemolytic activity while maintaining its high antibiotic activity, have been devoted.
2.Synthesis and evaluation of strand and turn modi?ed ring-extended gramicidin S derivatives
Annemiek D. Knijnenburg, Bioorganic & Medicinal Chemistry 19 (2011) 3402-3409
The increasing number of pathogenic bacteria that are resistant to clinically applied antibiotics has led to a search for potent new antibiotics with alternative targets. Cationic antimicrobial peptides (CAPs) comprise a broad class of molecules that target the lipid bilayer of bacteria. Bacteria do not easily build up resistance against such peptides, and therefore CAPs are considered as promising leads for the development of new antibiotics. A prominent member of the CAP family is the cyclo-decapeptide gramicidin S (GS) isolated from Aneurinibacillus migulans. Its secondary structure consists of a short antiparallel β-sheet interconnected by two type II’ β-turns. The amino acid sequence and its secondary structure render the molecule amphipathic with the cationic side chains oriented on one face of the b-sheet and the hydrophobic side chains on the opposing face. The cationic amphipathic characteristics of the peptide are responsible for its membrane disrupting properties, and GS is active against both Gram-positive and to a lesser extent against Gram-negative bacteria. In combination with the antibiotic agent framycetin, which targets Gram-negative bacteria, GS has proven to be an effective antibiotic against external ear infections.
3.Design and Synthesisof Gramicidin S Analogs with High Antibiotic Activity
Kazuki Sato, Bull. Chem. Soc. Jpn. Vol. 86, No. 1, 112--120 (2013)
Based on the research, the author designed a series of compounds as the analogs of an antibiotic gramicidin S (GS). GS, cyclo(-Val1,1’-Orn2,2’-Leu3,3’-D-Phe4,4’-Pro5,5’-)2, is a typical amphiphilic peptide known to take on intramolecular antiparallelβ-sheet conformation with twoβ-turns at D-Phe-Pro sequences. The characteristic feature of this conformation is the orientation of side chains in which charged Orn side chains are on one side and the hydrophobicVal and Leu side chains are on the other side of the molecule. From the study of many synthetic analogs in which these three residues were substituted, it was concluded that thisorientation of side chains was essentialfor the activityof GS.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Opioid Receptor Products

CAS 141801-26-5 Endomorphin 2

Endomorphin 2
(CAS: 141801-26-5)

Endomorphin 2, an andogenous peptide, has high affinity and specificity for the μ-opioid receptor and displays reasonable affinities for kappa3 binding sites, w...

CAS 1401031-39-7 TRV130 HCl

TRV130 HCl
(CAS: 1401031-39-7)

TRV130 is an opioid drug that is under evaluation in human clinical trials for the treatment of acute severe pain. It is a functionally selective μ-opioid recep...

CAS 122752-16-3 Deltorphin 2

Deltorphin 2
(CAS: 122752-16-3)

Deltorphin 2, an anion transporting peptid, is a selective peptide agonist for theδ opioid receptor.

CAS 16590-41-3 Naltrexone

(CAS: 16590-41-3)

Naltrexone, also called as Celupan, competitively antagonise μ, κ, δ, and σ-opioid receptors with the effect to reduce the occurrence of addictive behaviours .

Enadoline hydrochloride
(CAS: 124439-07-2)

Enadolineis a potent selective Opioid kappa receptor agonists originated by Pfizer. However, clinical trials for the treatment of Arrhythmias, Neuroprotection a...

(CAS: 105496-35-3)

LY-190388 is an μ receptor agonist. It is a penicillamine-containing enkephalin analog and has analgesia effect.

CAS 357-08-4 Naloxone hydrochloride

Naloxone hydrochloride
(CAS: 357-08-4)

Naloxone HCl is an opioid inverse agonist drug used to counter the effects of opiate overdose.

CAS 58-74-2 Papaverine

(CAS: 58-74-2)

Papaverine is an opiate alkaloid isolated from the plant Papaver somniferum. It is used primarily in the treatment of visceral spasm, vasospasm. It is also used...

CAS 77614-16-5 Dermorphin

(CAS: 77614-16-5)

Dermorphin, a naturally occurring heptapeptide originally found in the skin of amphibians, is a μ-opioid receptor(MOR) agonist with analgesic and antinociceptiv...

Alvimopan monohydrate
(CAS: 1383577-62-5)

The monohydrate salt form of Alvimopan could be commonly used in postoperative recovery of gastrointestinal for acting as a mu-opioid receptor (PAM-OR) antagoni...

(CAS: 854601-70-0)

Naloxegol is a CYP3A4 enzyme inhibitor. It is also a peripherally-selective opioid antagonist. It is used as the treatment of opioid-induced constipation. lt is...

(CAS: 676500-67-7)

Bevenopran is a peripherally selective μ- and δ-opioid receptor antagonist. It is used for the treatment of chronic opioid-induced constipation. It was develope...

CAS 156053-89-3 Alvimopan

(CAS: 156053-89-3)

Alvimopan is a novel, oral, peripherally acting antagonist of the mu opioid receptor, which can help gastrointestinal recovery after surgery. Phase III IC50: Mu...

CAS 1354744-91-4 Naloxegol oxalate

Naloxegol oxalate
(CAS: 1354744-91-4)

Naloxegol oxalate is a CYP3A4 enzyme inhibitor, is a peripherally-selective opioid antagonist, for the treatment of opioid-induced constipation.

(CAS: 676501-25-0)

Odelepran is a opioid receptor antagonist. It is used for the treatment of alcohol dependence. It was developed by Lilly and was in clinical phase 2 trial, but ...

CAS 170098-38-1 Alvimopan dihydrate

Alvimopan dihydrate
(CAS: 170098-38-1)

Alvimopan dihydrate is a novel, orally available peripherally restricted opioid antagonist with low systemic absorption. It accelerates the gastrointestinal rec...

(CAS: 1357348-09-4)

Lexanopadol is a potent Opioid mu receptor agonist originated by Grunenthal. Lexanopadol is suited for the management of moderate to severe chronic pain, includ...

LY 106737
(CAS: 82970-72-7)

LY 106737 is phenylpiperidine opioid receptor antagonist, but no detailed information has been published yet.

CAS 152685-85-3 Hemorphin-7

(CAS: 152685-85-3)

Hemorphin-7, a hemorphin peptide with antinociceptive and antihypertensive effects, is an endogenous opioid peptide derived from the β-chain of hemoglobin. Hemo...

CAS 1997387-43-5 PZM21

(CAS: 1997387-43-5)

PZM21 is a potent Gi activator with exceptional selectivity for μOR (EC50= 1.8 nM) and minimal β-arrestin-2 recruitment.

Chemical Structure

CAS 1354744-91-4 Naloxegol oxalate

Quick Inquiry

Verification code

Featured Items