Nagilactone B - CAS 19891-51-1
Catalog number: 19891-51-1
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C19H24O7
Molecular Weight:
364.4
COA:
Inquire
Chemical Family:
Diterpenoids
Description:
Nagilactone B isolated from the herbs of Podocarpus neriifolius.
Purity:
> 95%
Appearance:
Powder
Synonyms:
(1S)-1,2,3,3a,5aβ,6,10b,10cβ-Octahydro-1,2α,6α-trihydroxy-3aβ,10bα-dimethyl-7-isopropyl-4H,9H-furo[2',3',4':4,5]naphtho[2,1-c]pyran-4,9-dione
MSDS:
Inquire
Quality Standard:
Enterprise Standard
Quantity:
Milligrams-Grams
1.A novel small molecule liver X receptor transcriptional regulator, nagilactone B, suppresses atherosclerosis in apoE-deficient mice.
Gui Y;Yao S;Yan H;Hu L;Yu C;Gao F;Xi C;Li H;Ye Y;Wang Y Cardiovasc Res. 2016 Oct;112(1):502-14. doi: 10.1093/cvr/cvw183. Epub 2016 Jul 26.
AIMS: ;Atherosclerosis is the most common cause of cardiovascular diseases, such as myocardial infarction and stroke. We hypothesized that nagilactone B (NLB), a small molecule extracted from the root bark of Podocarpus nagi (Podocarpaceae), suppresses atherosclerosis in an atherosclerotic mouse model.;METHODS AND RESULTS: ;Male apoE-deficient mice on C57BL/6J background received NLB (10 and 30 mg/kg) for 12 weeks. Compared with the model group, NLB treatment (10 and 30 mg/kg) significantly reduced en face lesions of total aorta areas. In RAW264.7 cells, NLB significantly ameliorated cholesterol accumulation in macrophages via enhancing apolipoprotein A-I and HDL-mediated cholesterol efflux. Mechanistically, NLB induced messenger RNA and protein expression of the ATP-binding cassette transporter A1 (ABCA1) and G1 (ABCG1) in RAW264.7 and THP-1 cells. Liver X receptor (LXR) site mutations in the mouse ABCA1 promoter abrogated NLB-mediated luciferase reporter activity. LXRα and LXRβ small interfering RNA suppressed NLB-mediated induction of ABCA1 expression. Consistent with in vitro results, NLB induced ABCA1 expression and suppressed macrophage areas in the aortic sinus. Moreover, NLB treatment did not induce the protein expression of LXR in liver.
2.New podolactones from the seeds of Podocarpus nagi and their anti-inflammatory effect.
Feng ZL;Zhang T;Liu JX;Chen XP;Gan LS;Ye Y;Lin LG J Nat Med. 2018 May 11. doi: 10.1007/s11418-018-1219-5. [Epub ahead of print]
Podolactones are a class of structural diverse diterpenoid lactones, mainly isolated from the Podocarpus species. Several bioactivities have been disclosed for podolactones, including cytotoxicity and anti-atherosclerosis. In this study, the seeds of P. nagi were isolated by comprehensive chromatographic methods to obtain three new podolatones, named nagilactone B 1-O-β-D-glucoside (1), nagilactone N3 3-O-β-D-glucoside (2), and 2-epinagilactone B (3), as well as a known compound, nagilactone B (4). Their structures were determined by analyses of NMR and HRESIMS data. Compounds 1 and 2 significantly inhibited nitric oxide (NO) production on LPS-stimulated RAW264.7 macrophages, with IC;50; values of 0.18 ± 0.04 and 0.53 ± 0.03 μM, respectively. Indomethacin (IC;50; 4.21 ± 0.32 μM) was used as a positive control. Compound 1 suppressed the expression of inducible NO synthase (iNOS) in a concentration-dependent manner, mediating through inhibiting nuclear factor-κB (NF-κB) activity. This is the first report regarding the anti-inflammatory effect of podolactones, which could be potential anti-inflammatory agents.
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