Nagilactone B - CAS 19891-51-1
Catalog number: 19891-51-1
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Chemical Family:
Nagilactone B isolated from the herbs of Podocarpus neriifolius.
> 95%
Quality Standard:
Enterprise Standard
1.A novel small molecule liver X receptor transcriptional regulator, nagilactone B, suppresses atherosclerosis in apoE-deficient mice.
Gui Y;Yao S;Yan H;Hu L;Yu C;Gao F;Xi C;Li H;Ye Y;Wang Y Cardiovasc Res. 2016 Oct;112(1):502-14. doi: 10.1093/cvr/cvw183. Epub 2016 Jul 26.
AIMS: ;Atherosclerosis is the most common cause of cardiovascular diseases, such as myocardial infarction and stroke. We hypothesized that nagilactone B (NLB), a small molecule extracted from the root bark of Podocarpus nagi (Podocarpaceae), suppresses atherosclerosis in an atherosclerotic mouse model.;METHODS AND RESULTS: ;Male apoE-deficient mice on C57BL/6J background received NLB (10 and 30 mg/kg) for 12 weeks. Compared with the model group, NLB treatment (10 and 30 mg/kg) significantly reduced en face lesions of total aorta areas. In RAW264.7 cells, NLB significantly ameliorated cholesterol accumulation in macrophages via enhancing apolipoprotein A-I and HDL-mediated cholesterol efflux. Mechanistically, NLB induced messenger RNA and protein expression of the ATP-binding cassette transporter A1 (ABCA1) and G1 (ABCG1) in RAW264.7 and THP-1 cells. Liver X receptor (LXR) site mutations in the mouse ABCA1 promoter abrogated NLB-mediated luciferase reporter activity. LXRα and LXRβ small interfering RNA suppressed NLB-mediated induction of ABCA1 expression. Consistent with in vitro results, NLB induced ABCA1 expression and suppressed macrophage areas in the aortic sinus. Moreover, NLB treatment did not induce the protein expression of LXR in liver.
2.New podolactones from the seeds of Podocarpus nagi and their anti-inflammatory effect.
Feng ZL;Zhang T;Liu JX;Chen XP;Gan LS;Ye Y;Lin LG J Nat Med. 2018 May 11. doi: 10.1007/s11418-018-1219-5. [Epub ahead of print]
Podolactones are a class of structural diverse diterpenoid lactones, mainly isolated from the Podocarpus species. Several bioactivities have been disclosed for podolactones, including cytotoxicity and anti-atherosclerosis. In this study, the seeds of P. nagi were isolated by comprehensive chromatographic methods to obtain three new podolatones, named nagilactone B 1-O-β-D-glucoside (1), nagilactone N3 3-O-β-D-glucoside (2), and 2-epinagilactone B (3), as well as a known compound, nagilactone B (4). Their structures were determined by analyses of NMR and HRESIMS data. Compounds 1 and 2 significantly inhibited nitric oxide (NO) production on LPS-stimulated RAW264.7 macrophages, with IC;50; values of 0.18 ± 0.04 and 0.53 ± 0.03 μM, respectively. Indomethacin (IC;50; 4.21 ± 0.32 μM) was used as a positive control. Compound 1 suppressed the expression of inducible NO synthase (iNOS) in a concentration-dependent manner, mediating through inhibiting nuclear factor-κB (NF-κB) activity. This is the first report regarding the anti-inflammatory effect of podolactones, which could be potential anti-inflammatory agents.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Diterpenoids Products

CAS 78432-78-7 19-Hydroxybaccatin III

19-Hydroxybaccatin III
(CAS: 78432-78-7)

19-Hydroxybaccatin III isolated from the barks of Taxus. chinensis

CAS 107438-79-9 Ginkgolide J

Ginkgolide J
(CAS: 107438-79-9)

Ginkgolide J is extracted from the seed of Ginkgo biloba L. It reduces apoptotic damage in cultured chick embryonic neurons. It contributes to the antioxidant p...

CAS 52992-82-2 Acetylisocupressic acid

Acetylisocupressic acid
(CAS: 52992-82-2)

Acetylisocupressic acid isolated from the barks of Araucaria cunninghami.

CAS 40433-82-7 Pinusolidic acid

Pinusolidic acid
(CAS: 40433-82-7)

Pinusolidic acid isolated from the leaves of Platycladus orientalis.

CAS 102130-43-8 Atractyloside potassium salt

Atractyloside potassium salt
(CAS: 102130-43-8)

Atractyloside potassium salt is the potassium salt of atractyloside, which inhibits oxidative phosphorylation by blocking the transfer of adenosine nucleotides ...

CAS 1623410-12-7 Baccatin IX

Baccatin IX
(CAS: 1623410-12-7)

Baccatin IX is extracted from the leaves and twigs of Taxus yunnanensis.

CAS 57719-76-3 ent-11,15-Dihydroxykaur-16-en-19-oic acid

ent-11,15-Dihydroxykaur-16-en-19-oic aci
(CAS: 57719-76-3)

ent-11α,15α-Dihydroxykaur-16-en-19-oic acid is a natural diterpenoid found in the herbs of Cerbera manghas.

Caesalmin B
(CAS: 352658-23-2)

Caesalmin B is a natural flavonoid compound found in several plants.

CAS 67650-47-9 Methyl clerodermate

Methyl clerodermate
(CAS: 67650-47-9)

Methyl clerodermate is a natural diterpenoid isolated the herbs of Clerodendrum inerme.

(CAS: 1452398-07-0)

Sahandol is a natural compound extraced from some plant.

CAS 176520-13-1 Scutebarbatine A

Scutebarbatine A
(CAS: 176520-13-1)

Scutebarbatine A, a natural diterpenoid isolated from the herbs of Scutellaria barbata D. Don,exhibits the activity of anti-tumor via mitochondria-mediated apop...

Caesalmin E
(CAS: 204185-91-1)

Caesalmin E is a natural diterpenoid compound found in several plants.

CAS 1039673-32-9 15-Nor-14-oxolabda-8(17),12-dien-18-oic acid

(CAS: 1039673-32-9)

15-Nor-14-oxolabda-8(17),12-dien-18-oic acid isolated from the barks of Pinus yunnanensis.

CAS 74284-42-7 12-Oxograndiflorenic acid

12-Oxograndiflorenic acid
(CAS: 74284-42-7)

12-Oxograndiflorenic acid is extracted from the herbs of Siegesbeckia orientalis L.

CAS 438536-34-6 3(20)-Phytene-1,2-diol

(CAS: 438536-34-6)

3(20)-Phytene-1,2-diol is extracted from the leaves of Helianthus annuus L.

CAS 89498-91-9 Picrasinol B

Picrasinol B
(CAS: 89498-91-9)

Picrasinol B is a natural diterpenoid isolated from the herbs of Picrasma quassioides (D. Don) Benn

Pterisolic acid C
(CAS: 1401419-87-1)

Pterisolic acid C is a natural diterpenoid found in the herbs of Pteris semipinnata.

(CAS: 10391-08-9)

Isodocarpin is a natural diterpenoid compound found in several plants.

CAS 52557-26-3 Ingenol 3-palmitate

Ingenol 3-palmitate
(CAS: 52557-26-3)

Ingenol 3-palmitate is extracted from the latex of Euphorbia serrata. It displays cocarcinogenic and irritant activity on mouse ear and mice back skin.

CAS 167906-74-3 Taxachitriene A

Taxachitriene A
(CAS: 167906-74-3)

Taxachitriene A is extracted from the seeds of the Chinese yew Taxus chinensis.

Quick Inquiry

Verification code

Featured Items