Naftopidil - CAS 57149-07-2
Catalog number:
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Adrenergic Receptor
Naftopidil is a selective α1-adrenergic receptor antagonist or alpha blocker with a Ki of 58.3 nM.
Publictions citing BOC Sciences Products
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1.Molecularly imprinted polymeric stir bar: Preparation and application for the determination of naftopidil in plasma and urine samples.
Peng J1, Xiao D1, He H1,2, Zhao H3, Wang C1, Shi T1, Shi K1. J Sep Sci. 2016 Jan;39(2):383-90. doi: 10.1002/jssc.201500751.
In this study, molecularly imprinting technology and stir bar absorption technology were combined to develop a microextraction approach based on a molecularly imprinted polymeric stir bar. The molecularly imprinted polymer stir bar has a high performance, is specific, economical, and simple to prepare. The obtained naftopidil-imprinted polymer-coated bars could simultaneously agitate and adsorb naftopidil in the sample solution. The ratio of template/monomer/cross-linker and conditions of template removal were optimized to prepare a stir bar with highly efficient adsorption. Fourier transform infrared spectroscopy, scanning electron microscopy, selectivity, and extraction capacity experiments showed that the molecularly imprinted polymer stir bar was prepared successfully. To utilize the molecularly imprinted polymer stir bar for the determination of naftopidil in complex body fluid matrices, the extraction time, stirring speed, eluent, and elution time were optimized.
2.Action of naftopidil on spinal serotonergic neurotransmission for inhibition of the micturition reflex in rats.
Sugaya K1, Nishijima S1, Kadekawa K1, Ashitomi K1, Ueda T2, Yamamoto H3, Hattori T4. Neurourol Urodyn. 2016 Apr 29. doi: 10.1002/nau.23028. [Epub ahead of print]
AIMS: We examined the mechanism of action of naftopidil, an α1D/A blocker, on spinal descending serotonergic neurotransmission for the micturition reflex.
3.Piperazine-based Alpha-1 AR Blocker, Naftopidil, Selectively Suppresses Malignant Human Bladder Cells via Induction of Apoptosis.
Nakagawa YU1, Nagaya H2, Miyata T2, Wada Y2, Oyama T2, Gotoh A3. Anticancer Res. 2016 Apr;36(4):1563-70.
A retrospective observational cohort study has shown that exposure to alpha-1 adrenergic receptor (AR) blocker reduces the risk of bladder cancer (BCa). We investigated the antitumor activity of alpha-1 blockers, that are administered long-term therapeutically, in BCa. The antitumor activity of alpha-1 blockers was evaluated in terms of cell viability, cell cycle, competition, and apoptotic signaling in BCa cells. Our cell viability studies showed that naftopidil was one of the strongest alpha-1 AR blockers, regarding its antitumor action in BCa cells, independent of the grade of malignancy, but with no similar action on normal human bladder cells. Oral administration of naftopidil reduced tumor volume in a xenograft model. Our own competitive analysis using an alpha-1 AR agonist and other alpha-1 AR blockers showed that naftopidil activated cell death signaling without inhibitory action on alpha-1 ARs. We conclude that naftopidil has potential as an antitumor drug against BCa in vitro and in vivo.
4.Influence of Naftopidil on Plasma Monoamine Levels and Lower Urinary Tract Symptoms Associated with Benign Prostatic Hyperplasia.
Kadekawa K1,2, Sugaya K1,3, Mukoyama H4, Sakumoto M5, Shimabukuro H6, Shimabukuro S6, Matayoshi Y6, Onaga T2, Ashitomi K1,7, Nishijima S1. Low Urin Tract Symptoms. 2016 May;8(2):100-5. doi: 10.1111/luts.12079. Epub 2014 Nov 6.
OBJECTIVES: To clarify the influence of naftopidil, an α1D/A -adrenergic receptor antagonist, on the autonomic nervous system, we examined the relation between lower urinary tract symptoms (LUTS) and the plasma monoamine levels before and after naftopidil treatment in benign prostatic hyperplasia (BPH) patients.
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CAS 57149-07-2 Naftopidil

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