Naftopidil - CAS 57149-07-2
Catalog number:
57149-07-2
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C24H28N2O3
Molecular Weight:
392.49
COA:
Inquire
Targets:
Adrenergic Receptor
Description:
Naftopidil is a selective α1-adrenergic receptor antagonist or alpha blocker with a Ki of 58.3 nM.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Synonyms:
KT-611
MSDS:
Inquire
1.Molecularly imprinted polymeric stir bar: Preparation and application for the determination of naftopidil in plasma and urine samples.
Peng J1, Xiao D1, He H1,2, Zhao H3, Wang C1, Shi T1, Shi K1. J Sep Sci. 2016 Jan;39(2):383-90. doi: 10.1002/jssc.201500751.
In this study, molecularly imprinting technology and stir bar absorption technology were combined to develop a microextraction approach based on a molecularly imprinted polymeric stir bar. The molecularly imprinted polymer stir bar has a high performance, is specific, economical, and simple to prepare. The obtained naftopidil-imprinted polymer-coated bars could simultaneously agitate and adsorb naftopidil in the sample solution. The ratio of template/monomer/cross-linker and conditions of template removal were optimized to prepare a stir bar with highly efficient adsorption. Fourier transform infrared spectroscopy, scanning electron microscopy, selectivity, and extraction capacity experiments showed that the molecularly imprinted polymer stir bar was prepared successfully. To utilize the molecularly imprinted polymer stir bar for the determination of naftopidil in complex body fluid matrices, the extraction time, stirring speed, eluent, and elution time were optimized.
2.Action of naftopidil on spinal serotonergic neurotransmission for inhibition of the micturition reflex in rats.
Sugaya K1, Nishijima S1, Kadekawa K1, Ashitomi K1, Ueda T2, Yamamoto H3, Hattori T4. Neurourol Urodyn. 2016 Apr 29. doi: 10.1002/nau.23028. [Epub ahead of print]
AIMS: We examined the mechanism of action of naftopidil, an α1D/A blocker, on spinal descending serotonergic neurotransmission for the micturition reflex.
3.Piperazine-based Alpha-1 AR Blocker, Naftopidil, Selectively Suppresses Malignant Human Bladder Cells via Induction of Apoptosis.
Nakagawa YU1, Nagaya H2, Miyata T2, Wada Y2, Oyama T2, Gotoh A3. Anticancer Res. 2016 Apr;36(4):1563-70.
A retrospective observational cohort study has shown that exposure to alpha-1 adrenergic receptor (AR) blocker reduces the risk of bladder cancer (BCa). We investigated the antitumor activity of alpha-1 blockers, that are administered long-term therapeutically, in BCa. The antitumor activity of alpha-1 blockers was evaluated in terms of cell viability, cell cycle, competition, and apoptotic signaling in BCa cells. Our cell viability studies showed that naftopidil was one of the strongest alpha-1 AR blockers, regarding its antitumor action in BCa cells, independent of the grade of malignancy, but with no similar action on normal human bladder cells. Oral administration of naftopidil reduced tumor volume in a xenograft model. Our own competitive analysis using an alpha-1 AR agonist and other alpha-1 AR blockers showed that naftopidil activated cell death signaling without inhibitory action on alpha-1 ARs. We conclude that naftopidil has potential as an antitumor drug against BCa in vitro and in vivo.
4.Influence of Naftopidil on Plasma Monoamine Levels and Lower Urinary Tract Symptoms Associated with Benign Prostatic Hyperplasia.
Kadekawa K1,2, Sugaya K1,3, Mukoyama H4, Sakumoto M5, Shimabukuro H6, Shimabukuro S6, Matayoshi Y6, Onaga T2, Ashitomi K1,7, Nishijima S1. Low Urin Tract Symptoms. 2016 May;8(2):100-5. doi: 10.1111/luts.12079. Epub 2014 Nov 6.
OBJECTIVES: To clarify the influence of naftopidil, an α1D/A -adrenergic receptor antagonist, on the autonomic nervous system, we examined the relation between lower urinary tract symptoms (LUTS) and the plasma monoamine levels before and after naftopidil treatment in benign prostatic hyperplasia (BPH) patients.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Adrenergic Receptor Products


CAS 83474-08-2 Fenmetozole Tosylate

Fenmetozole Tosylate
(CAS: 83474-08-2)

Fenmetozole, also known as DH-524, is an antagonist of α2-adrenergic receptor and also antagonizes the actions of ethanol.

CAS 67346-49-0 (R,R)-Formoterol

(R,R)-Formoterol
(CAS: 67346-49-0)

(R,R)-Formoterol is a long acting beta-adrenoceptor agonist acts as a novel highly β2-selective adrenergic agonist and holds promise as a β2-agonist that could ...

CAS 13523-86-9 Pindolol

Pindolol
(CAS: 13523-86-9)

Pindolol, an Indole derivative, could be used in the treatment of hypertension and arrhythmia for acting as a 5-HT1A/1B receptor antagonist. IC50: 33nM(Ki).

CAS 1491-59-4 Oxymetazoline

Oxymetazoline
(CAS: 1491-59-4)

Oxymetazoline, an imidazol derivative, has been found to be an adrenergic receptor agonist that could be an effective topical decongestant.

CAS 65576-45-6 Asenapine

Asenapine
(CAS: 65576-45-6)

Asenapine is an atypical antipsychotic multireceptor neuroleptic drug by combining serotonin (5HT2) and dopamine (D2) receptor antagonist; structurally related ...

CAS 147568-66-9 Carmoterol

Carmoterol
(CAS: 147568-66-9)

Carmoterol, a quinolin derivative, has been found to a β2-adrenoceptor agonist that could be an effective bronchodilating agent.

CAS 22195-34-2 Guanadrel Hemisulfate

Guanadrel Hemisulfate
(CAS: 22195-34-2)

Guanadrel, as an antihypertensive agent, is an orally active postganglionic sympathetic inhibitor.

CAS 63659-18-7 Betaxolol

Betaxolol
(CAS: 63659-18-7)

Betaxolol is a selective beta1 adrenergic receptor blocker used in the treatment of hypertension and glaucoma.

CAS 72795-01-8 ICI 118551 hydrochloride

ICI 118551 hydrochloride
(CAS: 72795-01-8)

ICI 118551 hydrochloride is a highly selective β2 adrenergic antagonist (Ki values are 1.2, 120 and 257 nM for β2, β1 and β3 receptors respectively), inhibited ...

(RS)-Butyryltimolol

(RS)-Butyryltimolol is the racemate of Butyryltimolol which is the butyryl ester of Timolol. Timolol, in the non-selective β blocker family of medication, has b...

CAS 63-12-7 P2647

P2647
(CAS: 63-12-7)

P2647, also known as Benzquinamide, is a discontinued antiemetic compound with antihistaminic, mild anticholinergic, and sedative properties. P2647 binds to the...

CAS 57149-07-2 Naftopidil

Naftopidil
(CAS: 57149-07-2)

Naftopidil is a selective α1-adrenergic receptor antagonist or alpha blocker with a Ki of 58.3 nM.

Moxonidine hydrochloride
(CAS: 75536-04-8)

Moxonidine hydrochloride is a mixed agonist of α2-adrenergic receptor (α2AR) and imidazoline-1 receptor(I1R). Its Ki values is 4.2±3.2 nmol/L, 13.0±4.2 nmol/L, ...

CAS 856620-39-8 O-desmethyl Mebeverine alcohol hydrochloride

O-desmethyl Mebeverine alcohol hydrochlo
(CAS: 856620-39-8)

O-desmethyl Mebeverine alcohol hydrochloride, a metabolite of Mebeverine, is a potent inhibitor of α1 repector, causing relaxation of the gastrointestinal tract...

CP-331684
(CAS: 207922-70-1)

CP-331684 is a β3-adrenergic receptor agonist used as antidiabetic drug.

CAS 29110-48-3 Guanfacine HCl

Guanfacine HCl
(CAS: 29110-48-3)

Guanfacine HCl is the hydrochloride salt of Guanfacine. Guanfacine, a selective agonist of α2A receptor, is a sympatholytic drug to treat attention deficit hype...

CAS 106133-20-4 Tamsulosin

Tamsulosin
(CAS: 106133-20-4)

Tamsulosin could block on the sympathetic α1 receptor, especially selectively bind to the α1A receptor and has been found to be effective in the treatment of be...

CAS 868049-49-4 Olodaterol

Olodaterol
(CAS: 868049-49-4)

Olodaterol, also referred to BI1744, is a long acting β2-agonist (β2-ARs; EC50s = 97.7 and 2,725 nM for human β2- and β1-ARs, respectively) used as an inhalatio...

CAS 829-74-3 Levonordefrin

Levonordefrin
(CAS: 829-74-3)

Levonordefrin is a adrenergic receptor agonist and can be used as a topical nasal decongestant and vasoconstrictor in dentistry in the United States. Levonordef...

Nifenalol HCl

The hydrochloride of Nifenalol. Nifenalol is a beta-adrenoceptor antagonist used for the treatment of cardiovascular and cerebrovascular diseases such as hypert...

Chemical Structure

CAS 57149-07-2 Naftopidil

Quick Inquiry

Verification code

Featured Items