Nabumetone - CAS 42924-53-8
Catalog number: 42924-53-8
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C15H16O2
Molecular Weight:
228.29
COA:
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Targets:
Others
Description:
Nabumetone is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX.
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Purity:
>98%
Synonyms:
BRL-14777
MSDS:
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1.Fixed Drug Eruption Due to Selective Hypersensitivity to Naproxen with Tolerance to other Propionic Acid NSAIDs.
Noguerado-Mellado B1, Rodriguez Gamboa A, Rojas Perez-Ezquerra P, Morales Cabeza C, Pelta Fernandez R, De Barrio Fernandez M. Recent Pat Inflamm Allergy Drug Discov. 2016 Apr 4. [Epub ahead of print]
BACKGROUND: Naproxen is a non-steroidal anti-inflammatory drug (NSAID), belonging to propionic acid group, and its chemical structure is a 6-metoxi-metil-2-naftalenoacetic acid. Fixed drug eruptions (FDE) have been rarely reported.
2.Vortex-assisted surfactant-enhanced emulsification microextraction based on solidification of floating organic drop combined with high performance liquid chromatography for determination of naproxen and nabumetone.
Asadi M1, Haji Shabani AM2, Dadfarnia S3, Abbasi B4. J Chromatogr A. 2015 Dec 18;1425:17-24. doi: 10.1016/j.chroma.2015.11.005. Epub 2015 Nov 19.
A novel, rapid, simple and green vortex-assisted surfactant-enhanced emulsification microextraction method based on solidification of floating organic drop was developed for simultaneous separation/preconcentration and determination of ultra trace amounts of naproxen and nabumetone with high performance liquid chromatography-fluorescence detection. Some parameters influencing the extraction efficiency of analytes such as type and volume of extractant, type and concentration of surfactant, sample pH, KCl concentration, sample volume, and vortex time were investigated and optimized. Under optimal conditions, the calibration graph exhibited linearity in the range of 3.0-300.0ngL(-1) for naproxen and 7.0-300.0ngL(-1) for nabumetone with a good coefficient of determination (R(2)>0.999). The limits of detection were 0.9 and 2.1ngL(-1). The relative standard deviations for inter- and intra-day assays were in the range of 5.8-10.1% and 3.8-6.
3.[Clinical review of pseudoporphyria].
Velander MJ1, Þorsteinsdóttir S, Bygum A. Ugeskr Laeger. 2015 Feb 2;177(6). pii: V11140599.
Pseudoporphyria is a photosensitive bullous disease, which resembles porphyria cutanea tarda. Normal porphyrin levels in urine, stool and blood define pseudoporphyria. Pseudoporphyria is associated with chronic renal failure, haemodialysis, a variety of drugs (e.g. naproxen, nabumetone, furosemide, ciprofloxacin, voriconazole, acitretin), tanning beds and UVA exposure. Treatment consists of UV protection and cessation of suspected agents. Patients in haemodialysis can benefit from treatment with N-acetylcysteine or glutathione.
4.Nabumetone use and risk of acute pancreatitis in a case-control study.
Hung SC1, Liao KF2, Hung HC3, Lin CL4, Lai SW5, Lin CH6. Pancreatology. 2016 Mar 11. pii: S1424-3903(16)00054-5. doi: 10.1016/j.pan.2016.03.003. [Epub ahead of print]
BACKGROUND: It remains unknown whether nabumetone increases or decreases acute pancreatitis risk. To investigate this, we conducted a population-based case-control study using the database from the Taiwan National Health Insurance Program.
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CAS 42924-53-8 Nabumetone

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