|Description||Nabumetone is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX.|
3PO is originally reported to inhibit PFKFB3 (IC50 = 25 μM), with the potential to inhibit cancer cell proliferation. The addition of selective inhibitors of au...
Obestatin is a 23 amino acid bioactive peptide that encoded by the ghrelin gene. It can suppress food intake and reduce body weight-gain in rats.
SZL P1-41 is a Skp2 inhibitor that prevents assembly of Skp2-Skp1 complexes. SZL P1-41 selectively suppresses Skp2 SCF E3 ligase activity but not the activity o...
FR 121196 is a potential antidementia drug originated by Fujisawa. Mechanism of Action is not undefined. FR 121196 can ameliorate the impaired memory of rat in ...
TC HSD 21
TC HSD 21 is a potent 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitor (IC50 = 6 and 40 nM at human and mouse 17β-HSD3, respectively) with no activi...
AZ PFKFB3 26
AZ PFKFB3 26 is a selective and potent metabolic kinase PFKFB3 inhibitor with IC50 value of 0.023 μM. It is selective for PFKFB3 over PFKFB1 and PFKFB2 isoforms...
CGP 55802A has been found to be a photoaffinity ligand that could be used to label NMDA receptor and have high selectivity to glutamate recognition site.
AR12456 is a trapidil derivative. It could protect against serum hyperlipidemia in guinea pigs. It has a strong antilipidemic action in guinea pigs fed a choles...
(1S,3R)-RSL3 is an inhibitor of glutathione peroxidase 4 (GPX4) that induces ferroptosis and inhibits tumorigenesis.
TP 472N is a negative control for TP 472. TP 472N is inactive against other bromodomains (>20 μM against BRD9).
APC-366, an amino acid derivative, has been found to be a mast cell tryptase inhibitor and was once studied against asthma by Celera Genomics Group. Ki: 7.1 μM.
Talopram hydrochloride is a potent and selective inhibitor of the noradrenalin transporter (NET) (IC50 = 2.9 nM) that has selectivity for NET against SERT (5-HT...
A 350619 hydrochloride
A 350619 hydrochloride is an activator of soluble guanylyl cyclase (sGC) that stimulates basal sGC and synergistically activates sGC in the presence of NO. It i...
Furamidine dihydrochloride is a protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 9.4 μM) in the class of antimicrobial and antiparasitic agents. I...
AG-1801is a bio-active chemical for treatment of cell proliferative diseases.
ML239 is a breast cancer stem cells inhibitor with IC50 value of 1.16 μM.
Buflomedil HCl is a vasodilator used to treat claudication or the symptoms of peripheral arterial disease.
Carbosulfan is an organic compound adherent as a insecticide.
Arctiin has shown to be a suppressor of cyclin D1 protein expression in multiple types of human tumor cells, such as osteosarcoma, lung, colorectal, cervical, b...
CP-640186 is a potent inhibitor of mammalian ACCs and can reduce body weight and improve insulin sensitivity in test animals. It has recently been shown to be a...