|Description||N3PT inhibits transketolase activity in a cell based assay. Competitive inhibition of TK by N3PT in cells treated with increasing doses of thiamine, expressed as percentage enzymatic activity (the slope of initial linear range) of controls not treated with compounds. Tumors were induced in mice at day 0 and mice were then treated at day 7 with vehicle alone or with N3PT . Low-thiamine diet enhances the sensitivity to N3PT inhibition of TK in spleen. Animals were switched to diets containing 16.5 mg/kg (unchanged), 5 mg/kg, 1 mg/kg, or 0 mg/kg thiamine, from a normal chow containing 16.5mg/kg thiamine.|
Choline chloride is a quaternary ammonium salt used as an additive for animal feed, especially for chickens where it accelerates growth.
Ginsenoside Rh4 is a saponin isolated from the roots of Panax notoginseng (Burk.) F. H. Chen; used as adjuvant with low or non-haemolytic effect.
Schisandrin B(Wuweizisu-B) is a dibenzocyclooctadiene derivative isolated from Fructus Schisandrae, has been shown to produce antioxidant effect on rodent liver...
Extract from the plant of Argemone mexicana acts as an important intermediate in the biosynthesis of benzophenanthridine alkaloids, such as Sanguinarine.
An alkaloid FR 5 from Fritillaria thunbergii. An angiotensin converting enzyme inhibitory steroidal alkaloid. It is a commonly used antitussive and expectorant ...
AR12456 is a trapidil derivative. It protects against serum hyperlipidemia in guinea pigs. It has a strong antilipidemic action in guinea pigs fed a cholesterol...
ARN-5187, a piperazin derivative, has been found to be a REV-ERBβ inhibitor that could induce apoptotic in cancer cells and probably be more effective in breast...
3,3,5-Triiodo-L-thyronine(T3), an active metabolite of Thyroxine, could be effective in agonizing both thyroid hormone receptors TRα and TRβ so that might help ...
Fagomine is an iminosugar originally isolated from seeds of buckwheat (Fagopyrum sculentum Moench). It presents in the human diet and is now available as a pure...
FR-186054, a pyridine derivative, has been found to be a sterol O-acyltransferase inhibitor and was once studied in hyperlipidaemia.
CGP-15720 is a antitumor agent
(S)-(+)-Modafinic acid is the major metabolite of Modafinil(HY-10521A), which is a central nervous system vigilance promoting agent, which posseses neuroprotect...
Collagen proline hydroxylase inhibitor-1
Collagen proline hydroxylase inhibitor-1 is an antifibroproliferative agents.
Dirlotapide is a drug used to treat obesity in dogs works as a gut-selective microsomal triglyceride transfer protein (MTTP or MTP) inhibitor.
CEF4 is a peptide that corresponds to aa 342-351 of the influenza A virus nucleocapsid protein. CEF peptides are v-Src-induced cytokines from chicken embryo fib...
(-)-Eburnamonine is a vinca alkaloid shows protective effects on mice.
Berbamine hydrochloride, a natural compound derived from the Berberis amurensis plant, might affect the transport of intracellular Ca(2+).
Dropropizine is a racemic non-opiate antitussive agent, it is used as a cough suppressant.Dropropizine exhibits antitussive activity in cats noticeably lower th...
Bentiromide is a peptide used as diagnostic for pancreatic function.