|Description||Lucerastat is a selective α-D-galactosidase inhibitor. It can prevent glucosylceramide biosynthesis both in vitro and in mouse models of lysosome storage disorders through inhibiting the ceramide-specific glucosyltransferase, UDP-glucose ceramide glucosyltransferase (IC50 = 41.4 µM) but it does not affect α-glucosidase I and II or β-glucocerebrosidase (IC50s > 1 mM). In Jul 2016, Actelion completed phase Ib trial in Fabry's disease,but no development was reported for the treatment of Lipid metabolism disorders.|
|Appearance||Off-White to Pale Yellow Solid|
|Application||lipid storage disorders and Fabry's disease.|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Boiling Point||No Data Available|
|Current Developer||Originator Actelion Pharmaceuticals|
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