N-Acetyl-β-Asp-Glu - CAS 4910-46-7
Catalog number: 4910-46-7
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C11H16N2O8
Molecular Weight:
304.25
COA:
Inquire
Targets:
Others
Description:
N-Acetyl-β-Asp-Glu is a peptide neurotransmitter and the third-most-prevalent neurotransmitter in the mammalian nervous system.
Purity:
≥98%
Appearance:
Solid powder
Synonyms:
N-(N-Acetyl-L-beta-aspartyl)-L-glutamic acid; Spaglumic Acid
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
A peptide neurotransmitter
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly.
Quantity:
Milligrams-Grams
InChIKey:
GUCKKCMJTSNWCU-UHFFFAOYSA-N
InChI:
1S/C11H16N2O8/c1-5(14)12-7(4-9(17)18)10(19)13-6(11(20)21)2-3-8(15)16/h6-7H,2-4H2,1H3,(H,12,14)(H,13,19)(H,15,16)(H,17,18)(H,20,21)
Canonical SMILES:
CC(N[C@@H](OC(O)=O)CCN[C@@H](OC(O)=O)CCOC(O)=O)=O
1.Synthesis of acyclic and dehydroaspartic acid analogues of Ac-Asp-Glu-OH and their inhibition of rat brain N-acetylated alpha-linked acidic dipeptidase (NAALA dipeptidase).
Subasinghe N1, Schulte M, Chan MY, Roon RJ, Koerner JF, Johnson RL. J Med Chem. 1990 Oct;33(10):2734-44.
The following structural and conformationally constrained analogues of Ac-Asp-Glu-OH (1) were synthesized: Ac-Glu-Glu-OH (2), Ac-D-Asp-Glu-OH (3), Ac-Glu-Asp-OH (4), Ac-Asp-Asp-OH (5), Ac-Asp-3-aminohexanedioic acid (6), Ac-3-amino-3-(carboxymethyl)propanoyl-Glu-OH (7), N-succinyl-Glu-OH (8), N-maleyl-Glu-OH (9), N-fumaryl-Glu-OH (10), and Ac-delta ZAsp-Glu-OH (11). These analogues were evaluated for their ability to inhibit the hydrolysis of Ac-Asp-[3,4-3H]-Glu-OH by N-acetylated alpha-linked acidic dipeptidase (NAALA dipeptidase) in order to gain some insight into the structural requirements for the inhibition of this enzyme. Analogues 4-6 and 9 were very weak inhibitors of NAALA dipeptidase (Ki greater than 40 microM), while 2, 3, and 7 with Ki values ranging from 3.2-8.5 microM showed intermediate inhibitory activity. The most active inhibitors of NAALA dipeptidase were compounds 8, 10, and 11 with Ki values of 0.9, 0.4, and 1.4 microM, respectively.
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CAS 4910-46-7 N-Acetyl-β-Asp-Glu

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