N-(5-Carboxypentyl)-deoxynojirimycin - CAS 79206-70-5
Category: Carbohydrates
Molecular Formula:
C12H23NO6
Molecular Weight:
277.31
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Structure\Application:
Monosaccharides
Related CAS:
79206-51-2
Synonyms:
N-(5-Carboxypentyl)-1,5-dideoxy-1,5-imino-D-glucitol; (2R,3R,4R,5S)-3,4,5-Trihydroxy-2-(hydroxymethyl)-1-piperidinehexanoic acid
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1.N-methyl-N-(5-carboxypentyl)-1-deoxynojirimycin, a new affinity ligand for the purification of trimming glucosidase I.
Bause E1, Gross A, Schweden J. FEBS Lett. 1991 Jan 28;278(2):167-70.
The paper describes the synthesis of a new type of affinity resin containing N-methyl-N-(5-carboxypentyl)-1-deoxynojirimycin as the ligand attached to AH-Sepharose 4B, which allows the purification of trimming glucosidase I from a detergent extract of pig liver crude microsomes in one step and with high yield. The structure of the affinity ligand was designed on the basis of the observation that N,N-dialkylated derivatives of 1-deoxynojirimycin do strongly inhibit trimming glucosidase I, but not nonspecific aryl-alpha-glucosidases, including glucosidase II. The specific binding of glucosidase I eliminates the need of additional purification steps with their associated losses which were required with the previously synthesized N-5(-carboxypentyl)-AH-Sepharose 4B resin in order to achieve a homogenous enzyme preparation.
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CAS 79206-70-5 N-(5-Carboxypentyl)-deoxynojirimycin

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