Myricetin - CAS 529-44-2
Catalog number: 529-44-2
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
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Myricetin is a flavonoid found in many grapes, berries, fruits, vegetables, herbs, as well as other plants, which has antioxidant and anti tumor properties. Studies shows that high myricetin consumption reduces the risk of prostate cancer and pancreatic cancer.
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1.Anti-inflammatory activity of myricetin from Diospyros lotus through suppression of NF-κB and STAT1 activation and Nrf2-mediated HO-1 induction in lipopolysaccharide-stimulated RAW264.7 macrophages.
Cho BO1,2, Yin HH1, Park SH3, Byun EB3, Ha HY4, Jang SI1,2. Biosci Biotechnol Biochem. 2016 Apr 12:1-11. [Epub ahead of print]
Diospyros lotus is traditionally used for the treatment of diabetes, diarrhea, tumor, and hypertension. The purpose of this study was to investigate the anti-inflammatory effect and underlying molecular mechanisms of myricetin in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. Myricetin dose-dependently suppressed the production of pro-inflammatory mediators (NO, iNOS, PGE2, and COX-2) in LPS-stimulated RAW264.7 macrophages. Myricetin administration decreased the production of NO, iNOS, TNF-α, IL-6, and IL-12 in mice. Myricetin decreased NF-κB activation by suppressing the degradation of IκBα, nuclear translocation of p65 subunit of NF-κB, and NF-κB DNA binding activity in LPS-stimulated RAW264.7 macrophages. Moreover, myricetin attenuated the phosphorylation of STAT1 and the production of IFN-β in LPS-stimulated RAW264.7 macrophages. Furthermore, myricetin induced the expression of HO-1 through Nrf2 translocation. In conclusion, these results suggest that myricetin inhibits the production of pro-inflammatory mediators through the suppression of NF-κB and STAT1 activation and induction of Nrf2-mediated HO-1 expression in LPS-stimulated RAW264.
2.Antitumour activity of the novel flavonoid Oncamex in preclinical breast cancer models.
Martínez-Pérez C1, Ward C1, Turnbull AK1, Mullen P2, Cook G3, Meehan J1, Jarman EJ1, Thomson PI4, Campbell CJ4, McPhail D3, Harrison DJ2, Langdon SP1. Br J Cancer. 2016 Apr 12;114(8):905-16. doi: 10.1038/bjc.2016.6. Epub 2016 Mar 31.
BACKGROUND: The natural polyphenol myricetin induces cell cycle arrest and apoptosis in preclinical cancer models. We hypothesised that myricetin-derived flavonoids with enhanced redox properties, improved cell uptake and mitochondrial targeting might have increased potential as antitumour agents.
3.Myricitrin and bioactive extract of Albizia amara leaves: DNA protection and modulation of fertility and antioxidant-related genes expression.
Kassem ME1, Ibrahim LF1, Hussein SR1, El-Sharawy R1, El-Ansari MA1, Hassanane MM2, Booles HF2. Pharm Biol. 2016 Apr 6:1-6. [Epub ahead of print]
CONTEXT: Albizia species are reported to exhibit many biological activities including antiovulatory properties in female rats and antispermatogenic and antiandrogenic activities in male rats.
4.Myricetin exhibits anti-glioma potential by inducing mitochondrial-mediated apoptosis, cell cycle arrest, inhibition of cell migration and ROS generation.
Li HG1, Chen JX, Xiong JH, Zhu JW. J BUON. 2016 Jan-Mar;21(1):182-90.
PURPOSE: To study the antiproliferative effects of myricetin in human glioma U251 cells together with assessing its effects on cell cycle, apoptosis, apoptosis-related proteins, reactive oxygen species (ROS) generation and cell migration.
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CAS 529-44-2 Myricetin

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