Mycophenolic acid - CAS 24280-93-1
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Not Intended for Therapeutic Use. For research use only.
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Mycophenolic acid is a potent IMPDH inhibitor and the active metabolite of an immunosuppressive drug, used to prevent rejection in organ transplantation.It inhibits an enzyme needed for the growth of T cells and B cells.
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Mycophenolate, RS-61443
1.A Longitudinal Analysis of Outcomes of Lupus Nephritis in an International Inception Cohort Using a Multistate Model Approach.
Hanly JG1, Su L2, Urowitz MB3, Romero-Diaz J4, Gordon C5, Bae SC6, Bernatsky S7, Clarke AE8, Wallace DJ9, Merrill JT10, Isenberg DA11, Rahman A11, Ginzler EM12, Petri M13, Bruce IN14, Dooley MA15, Fortin P16, Gladman DD3, Sanchez-Guerrero J3, Steinsson K1 Arthritis Rheumatol. 2016 Mar 18. doi: 10.1002/art.39674. [Epub ahead of print]
OBJECTIVE: To study bidirectional change and predictors of change in estimated glomerular filtration rate (eGFR) and proteinuria (ePrU) in lupus nephritis (LN) using a multistate modelling approach.
2.Expression of UGT1A Subfamily in Rat Brain.
Sakakibara Y1, Katoh M1, Imai K1, Kondo Y1, Asai Y, Ikushiro SI2, Nadai M1. Biopharm Drug Dispos. 2016 Apr 7. doi: 10.1002/bdd.2012. [Epub ahead of print]
UDP-glucuronosyltransferase (UGT) is an enzyme that catalyzes a major phase II reaction in drug metabolism. Glucuronidation occurs mainly in the liver, but UGTs are also expressed in extrahepatic tissues, where they play an important role in local metabolism. UGT1A isoforms catalyze the glucuronidation of several drugs, neurotransmitters, and neurosteroids that exert pharmacological and physiological effects on the brain. The aim of the current study was to determine UGT1A mRNA expression levels and glucuronidation activity in different regions of the rat brain (namely the cerebellum, frontal cortex, parietal cortex, piriform cortex, hippocampus, medulla oblongata, olfactory bulb, striatum and thalamus). We found that all UGT1A isoforms were expressed in all the nine regions, but their expression levels differed between the regions. The difference between the regions of the brain where the mRNA levels were highest and those where they were lowest ranged between 2.
3.Therapeutic drug monitoring of enteric-coated mycophenolate sodium by limited sampling strategies is associated with a high rate of failure.
Hougardy JM1, Maufort L1, Cotton F2, Coussement J1, Mikhalski D1, Wissing KM3, Le Moine A1, Broeders N1, Abramowicz D4. Clin Kidney J. 2016 Apr;9(2):319-23. doi: 10.1093/ckj/sfw001. Epub 2016 Mar 1.
BACKGROUND: Therapeutic drug monitoring of mycophenolic acid (MPA) is usually performed with a limited sampling strategy (LSS), which relies on a limited number of blood samples and subsequent extrapolation of the global exposure to MPA. LSS is usually performed successfully with mycophenolate mofetil (MMF), but data on enteric-coated mycophenolate sodium (EC-MPS) are scarce. Here, we evaluated the feasibility of 6-h LSS therapeutic drug monitoring with EC-MPS compared with MMF monitoring among kidney transplant recipients.
4.The Value of Monitoring the Serum Concentration of Mycophenolate Mofetil in Children with Steroid-Dependent/Frequent Relapsing Nephrotic Syndrome.
Tong K1, Mao J, Fu H, Shen H, Liu A, Shu Q, Du L. Nephron. 2016 Mar 19. [Epub ahead of print]
BACKGROUND: Mycophenolate mofetil (MMF) is an alternative treatment strategy in children with steroid sensitivity who have frequent relapses or steroid-dependent nephrotic syndrome (FRNS/SDNS).
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CAS 24280-93-1 Mycophenolic acid

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