MX69 - CAS 1005264-47-0
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C27H26N2O4S
Molecular Weight:
474.57
COA:
Inquire
Targets:
IAP | MDM-2, p53
Description:
MX69 inhibits expression of both MDM2 and XIAP, used for cancer treatment. MX69 blocks the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation.
Publictions citing BOC Sciences Products
  • >> More
Appearance:
Solid powder
Synonyms:
4-(8-(N-(2,3-dimethylphenyl)sulfamoyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl)benzoic acid; MX69; MX-69; MX 69.
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
Inquire
Boiling Point:
678.1±65.0 °C at 760 Torr
Density:
1.324±0.06 g/cm3
InChIKey:
LAISWEODQAOXGJ-UHFFFAOYSA-N
InChI:
1S/C27H26N2O4S/c1-16-5-3-8-24(17(16)2)29-34(32,33)20-13-14-25-23(15-20)21-6-4-7-22(21)26(28-25)18-9-11-19(12-10-18)27(30)31/h3-6,8-15,21-22,26,28-29H,7H2,1-2H3,(H,30,31)
Canonical SMILES:
O=S(C1=CC2=C(NC(C3=CC=C(C(O)=O)C=C3)C4C2C=CC4)C=C1)(NC5=C(C)C(C)=CC=C5)=O
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related IAP Products


CAS 939981-39-2 RO5045337

RO5045337
(CAS: 939981-39-2)

RO5045337, also known as R7112, RG7112, is a MDM2 antagonist with potential antineoplastic activity. RO5045337 binds to MDM2, thereby preventing the binding of...

Kevetrin hydrochloride
(CAS: 66592-89-0)

Kevetrin hydrochloride is a water-soluble small molecule with potential antineoplastic activity.

UC 112
(CAS: 383392-66-3)

UC-112 is an IAP inhibitor (IC50 values from 0.7 - 3.4 μM). UC-112 also potently inhibits the growth of P-glycoprotein.

CAS 1258392-53-8 AZD-5582

AZD-5582
(CAS: 1258392-53-8)

AZD5582 is a potent IAP inhibitor, which is a dimeric compound based on the AVPI motif of Smac. AZD5582 binds potently to the BIR3 domains of cIAP1, cIAP2, and ...

CAS 675576-97-3 Nutlin-3b

Nutlin-3b
(CAS: 675576-97-3)

Nutlin-3b, the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM.

NSC59984
(CAS: 803647-40-7)

NSC59984 is a p53 pathway activator via induction of mutant p53 protein degradation and p73 activation.

CAS 1446182-94-0 GDC-0917

GDC-0917
(CAS: 1446182-94-0)

CUDC-427, also known as, GDC-0917, is an orally available, monovalent mimetic of second mitochondrial-derived activator of caspases (Smac/DIABLO) and inhibitor...

CAS 431979-47-4 SJ 172550

SJ 172550
(CAS: 431979-47-4)

SJ 172550 is a MDMX inhibitor (EC50 = 2.3 μM), controls the biological activity of MDMX.

CAS 1448867-41-1 NVP-HDM201

NVP-HDM201
(CAS: 1448867-41-1)

NVP-HDM201 (HDM201) is a potent and highly specific MDM-2/p53 inhibitor that binds to human Mdm2 protein with a sub-nanomolar Ki value, activates p53 and induce...

CAS 213261-59-7 RITA (NSC 652287)

RITA (NSC 652287)
(CAS: 213261-59-7)

CAS 1303607-60-4 MI-773

MI-773
(CAS: 1303607-60-4)

MI-773 (SAR405838) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.

CAS 873652-48-3 GDC-0152

GDC-0152
(CAS: 873652-48-3)

GDC-0152 is a second mitochondrial activator of caspases (Smac) mimetic inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activi...

CAS 1001600-56-1 BV6

BV6
(CAS: 1001600-56-1)

BV6 is a small-molecule Smac mimetic, which antagonizes IAP and induces autoubiquitination and subsequent proteasomal degradation of cIAP1 and cIAP2.

CAS 881202-45-5 Serdemetan

Serdemetan
(CAS: 881202-45-5)

Serdemetan, also known as JNJ-26854165, is an orally bioavailable, small-molecule HDM2 antagonist with potential antineoplastic activity. HDM2 antagonist JNJ-2...

CAS 1352066-68-2 AMG232

AMG232
(CAS: 1352066-68-2)

AMG232 is an extremely potent MDM2 inhibitor with remarkable pharmacokinetic properties and in vivo antitumor activity in the SJSA-1 osteosarcoma xenograft mode...

ASTX-660 Freebase
(CAS: 1605584-14-2)

ASTX-660 is found to be an IAP as well as XIAP inhitor that could be significant in the studies of lymphoma and solid tumours. It is still under Phase I/II tria...

CAS 1229705-06-9 Idasanutlin

Idasanutlin
(CAS: 1229705-06-9)

Idasanutlin; also known as RG7388 and RO5503781, is a highly potent and selective MDM2 antagonist with potential anticancer activity. RG7388 binds to MDM2 block...

ASTX-660 2HCl
(CAS: 1605316-16-2)

The dihydrochloride salt form of ASTX-660 which is found to be an IAP as well as XIAP inhitor that could be significant in the studies of lymphoma and solid tum...

CAS 63208-82-2 Pifithrin-α

Pifithrin-α
(CAS: 63208-82-2)

Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes.

CAS 957135-43-2 SM-164

SM-164
(CAS: 957135-43-2)

SM-164 is a potent cell-permeable and bivalent Smac mimetic which bind to a XIAP protein and binds to cIAP-1 and cIAP-2 proteins. It is developed as an antican...

Chemical Structure

CAS 1005264-47-0 MX69

Quick Inquiry

Verification code

Featured Items