Murralongin - CAS 53011-72-6
Catalog number: 53011-72-6
Not Intended for Therapeutic Use. For research use only.
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Murralongin isolated from the herbs of Murraya exotica L. It exhibits cytotoxicity against cholangiocarcinoma cell line, KKU-100.
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1.Bioactive coumarins from the leaves of Murraya omphalocarpa.
Chen KS;Wu CC;Chang FR;Chia YC;Chiang MY;Wang WY;Wu YC Planta Med. 2003 Jul;69(7):654-7.
Using antiplatelet aggregation as a guide to fractionation, eight coumarins, omphalocarpinol (1), 5,7-dimethoxy-8-(3'-methyl-2'-oxobutyl)coumarin (2), murralongin, murrayanone, omphamurin (5), murragleinin, mexoticin, and murrangatin, were isolated from the leaves of Murraya omphalocarpa. Compound 1 is new, and 5 is a new enantiomer of omphamurin. The structures of these compounds were elucidated on the basis of spectroscopic techniques, and the structure of compound 1 was confirmed by X-ray crystallographic analysis. Among them, compounds 1, 2 and 5 exhibited significant antiplatelet aggregation activity.
2.Coumarins from Galipea panamensis and Their Activity against Leishmania panamensis.
Arango V;Robledo S;Séon-Méniel B;Figadère B;Cardona W;Sáez J;Otálvaro F J Nat Prod. 2010 May 28;73(5):1012-4. doi: 10.1021/np100146y.
Two new coumarin compounds (1 and 2), phebalosin (3), its derived artifact murralongin (4), and murrangatin acetonide (5) were isolated from the leaves of Galipea panamensis. The structures of 1 and 2 were assigned as 7-{[(2R*)-3,3-dimethyloxiran-2-yl]methoxy}-8-[(2R*,3R*)-3-isopropenyloxiran-2-yl]-2H-chromen-2-one and 7-methoxy-8-(4-methyl-3-furyl)-2H-chromen-2-one, respectively, on the basis of their spectroscopic data (primarily NMR and MS). Compounds 1-3 were tested against axenic amastigote forms of Leishmania panamensis and displayed 50% effective concentrations (EC(50)) of 9.9, 10.5, and 14.1 microg/mL, respectively. These three compounds also displayed cytotoxicity (IC(50)) at concentrations of 9.7, 33.0, and 20.7 microg/mL, respectively, on human promonocytic U-937 cells.
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CAS 53011-72-6 Murralongin

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