Mulberroside A - CAS 102841-42-9
Catalog number: 102841-42-9
Category: Inhibitor
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Mulberroside A, extracted from the root bark of white mulberry, could reduce P-gp expression and function being along with the activation of PKC and NF-κB. It has potential effect in the treatment of prevention of high uric acid and gout disease.
3-{(E)-2-[4-(beta-D-glucopyranosyloxy)-2-hydroxyphenyl]ethenyl}-5-hydroxyphenyl beta-D-glucopyranoside
DMSO: 40 mg/mL
-20ºC Freeze
Mulberroside A, extracted from the root bark of white mulberry, could reduce P-gp expression and function being along with the activation of PKC and NF-κB.
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
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1.Down-regulation of P-gp expression and function after Mulberroside A treatment: potential role of protein kinase C and NF-kappa B.
Li Y1, Huang L2, Zeng X1, Zhong G1, Ying M1, Huang M3, Bi H4. Chem Biol Interact. 2014 Apr 25;213:44-50. doi: 10.1016/j.cbi.2014.02.004. Epub 2014 Feb 14.
P-Glycoprotein (P-gp) plays a major role in drug-drug and herb-drug interactions. Mulberroside A (Mul A) is one of the main bioactive constituents of Sangbaipi, the dried root-bark of Morus alba L. (white mulberry), which is officially listed in the Chinese Pharmacopoeia. In the present study, we investigated the effect of Mul A treatment on mRNA expression and protein expression of P-gp in the Caco-2 cells by real-time qPCR and Western blot analysis. The effect of Mul A treatment on the function of P-gp in vitro and in vivo was assessed by Rho123 transport assay and a pharmacokinetic study. The potential roles of protein kinase C (PKC) and nuclear factor kappa B (NF-κB) in the expression regulation of P-gp after Mul A treatment were also investigated. The results revealed that Mul A treatment significantly decreased the mRNA and protein expression of P-gp in Caco-2 cells after treatment with Mul A (5-20 μM). Furthermore, Mul A treatment displayed apparently inhibitory effect on the function of P-gp both in vitro and in vivo.
2.Antihyperlipidemic effects of stilbenoids isolated from Morus alba in rats fed a high-cholesterol diet.
Jo SP1, Kim JK2, Lim YH3. Food Chem Toxicol. 2014 Mar;65:213-8. doi: 10.1016/j.fct.2013.12.040. Epub 2014 Jan 7.
Mulberroside A (MUL) was purified from an ethanol extract of Morus alba root, and oxyresveratrol (OXY) was produced by enzymatic conversion of MUL. Normal rats, Triton WR-1339-induced hyperlipidemic rats, and high-cholesterol diet (HCD)-induced hyperlipidemic rats were orally treated with MUL or OXY (1-5mg/kg/day). MUL and OXY were administered 1h prior to concomitant treatment with Triton WR-1339 for a further 24h, whereas the drugs were administered concurrently with HCD for 4weeks. Oral MUL and OXY pre-treatment vs. water pre-treatment of Triton WR-1339-induced hyperlipidemic rats significantly (p<0.05) reduced the levels of serum lipids in a dose-dependent manner, while high-density lipoprotein cholesterol (HDL-C, or "good" cholesterol) levels were increased. Oral MUL and OXY treatment of HCD-fed rats also showed a significant (p<0.05) dose-dependent decrease in serum lipids, coronary artery risk index (CRI), and atherogenic index (AI), but not HDL-C.
3.[Comparative and correlational studies on contents of stilbenes in different portions of mulberry].
Zhou J1, Li SX2, Yan XP3, Ji M2, Guo XY2, Huang D2, Zheng QY4. Zhongguo Zhong Yao Za Zhi. 2013 Oct;38(19):3261-4.
OBJECTIVE: To compare the contents of stilbenes in different parts and axial root bark of mulberry, and study their correlation.
4.[Quality standard study on Mori Cortex liquid extract].
Liu MF, Xie MP, Li L, Lu AQ, Shi JG, Wang SJ. Zhongguo Zhong Yao Za Zhi. 2015 May;40(10):1850-4.
A reasonable and practicable quality standard was developed for mori liquid extract from different sources by TLC, HPLC and fingerprint technology. In TLC method, the compounds were separated on polyamide film using glacial acetic acid-water (1: 3) as mobile phase at a UV wavelength of 365 nm. All qualified samples had the spots of the same color as the control herb and substance. The RP-HPLC method was used to determine the content of mulberroside A with mobile phase of methanol-water (25: 75) at a wave-length of 326 nm. The mulberroside A was in good linear with a regression equation of Y = 46.965X (r = 0.999 6) in the range of 4.6 - 228 mg x L(-1). In 14 batches of samples, the mulberroside A in 4 batches of them was less than 0.5 g x L(-1), and was more than 2.0 g x L(-1) in the other batches. It was suggested that the content limit of mulberroside A should be no less than 1.5 g x L(-1). The HPLC fingerprints were evaluated by the similarities.
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CAS 102841-42-9 Mulberroside A

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