MS-073 - CAS 129716-45-6
Catalog number: 129716-45-6
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C31H33N3O2
Molecular Weight:
479.62
COA:
Inquire
Targets:
DNA/RNA Synthesis
Description:
MS-073 is a Type II DNA topoisomerase inhibitor under the development of Nihon Schering. MS-073 can overcome MDR in vitro and in vivo compare to verapamil. MS-073 at 0.1 mM can almost completely reverse in vitro resistance to vincristine in vincristine-resistant P388 cells. MS-073 can also reverse in vitro vincristine, adriamycin, etoposide, and actinomycin D resistance in adriamycin-resistant human myelogenous leukemia K562 cells. MS-073 reverses MDR through competitively inhibiting drug binding to P-glycoprotein. Treatment for cancer was discontinued.
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Purity:
98%
Appearance:
Powder
Synonyms:
CP-162398;1-(Quinolin-5-yloxy)-3-[4-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten)-5-yl]piperazin-1-yl]-2-propanol
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Cancer
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
YLQSXCMKFKBZLE-UHFFFAOYSA-N
InChI:
1S/C31H33N3O2/c35-25(22-36-30-13-5-12-29-28(30)11-6-16-32-29)21-33-17-19-34(20-18-33)31-26-9-3-1-7-23(26)14-15-24-8-2-4-10-27(24)31/h1-13,16,25,31,35H,14-15,17-22H2
Canonical SMILES:
N1(CCN(CC1)C1c2c(CCc3c1cccc3)cccc2)C[C@@H](O)COc1c2cccnc2ccc1
Current Developer:
Nihon Schering
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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Chemical Structure

CAS 129716-45-6 MS-073

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