MRT-83 hydrochloride - CAS 1359944-60-7
Catalog number:
1359944-60-7
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C31H31ClN4O5
Molecular Weight:
575.06
COA:
Inquire
Targets:
Smo
Description:
MRT-83 is a Smoothened (Smo) antagonist. It can block Hedgehog (Hh) signaling in various assays. MRT-83 can also inhibit Bodipy-cyclopamine binding to human and mouse Smo. MRT-83 can efficiently antagonize Hh signaling in vivo. MRT-83 may help develop new therapies for the treatment of Hh-pathway related diseases.
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Purity:
98%
Appearance:
Powder
Synonyms:
N-(2-methyl-5-(3-(3,4,5-trimethoxybenzoyl)guanidino)phenyl)-[1,1'-biphenyl]-4-carboxamide hydrochloride;1263131-92-5 (free base)
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Hh-pathway related diseases
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
Canonical SMILES:
O=C(NC(NC1=CC=C(C)C(NC(C2=CC=C(C3=CC=CC=C3)C=C2)=O)=C1)=N)C4=CC(OC)=C(OC)C(OC)=C4.[H]Cl
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