MRT-83 - CAS 1263131-92-5
Catalog number:
1263131-92-5
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C31H30N4O5
Molecular Weight:
538.59
COA:
Inquire
Targets:
Smo
Description:
This active molecular is a novel potent Smoothened antagonist. MRT-83 blocks Hedgehog (Hh) signaling in various assays and IC50 can be in nmol range, showing greater potency than cyclopamine, another Smoothened antagonist. MRT-83 efficiently antagonizes Hh signaling in vivo. MRT-83 will be useful for manipulating Hh signaling and may help develop new treatment for Hh-pathway related diseases.
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Purity:
98%
Appearance:
Powder
Synonyms:
N-[5-[[imino[(3,4,5-trimethoxybenzoyl)amino]methyl]amino]-2-methylphenyl]-[1,1'-Biphenyl]-4-carboxamide;1359944-60-7 (HCl salt)
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Hh-pathway related diseases
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChI:
InChI=1S/C31H30N4O5/c1-19-10-15-24(33-31(32)35-30(37)23-16-26(38-2)28(40-4)27(17-23)39-3)18-25(19)34-29(36)22-13-11-21(12-14-22)20-8-6-5-7-9-20/h5-18H,1-4H3,(H,34,36)(H3,32,33,35,37)
Canonical SMILES:
COC1=C(OC)C(OC)=CC(C(NC(NC2=CC(NC(C3=CC=C(C4=CC=CC=C4)C=C3)=O)=C(C)C=C2)=N)=O)=C1
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