|Description||This active molecular is a novel potent Smoothened antagonist. MRT-83 blocks Hedgehog (Hh) signaling in various assays and IC50 can be in nmol range, showing greater potency than cyclopamine, another Smoothened antagonist. MRT-83 efficiently antagonizes Hh signaling in vivo. MRT-83 will be useful for manipulating Hh signaling and may help develop new treatment for Hh-pathway related diseases.|
|Synonyms||N-[5-[[imino[(3,4,5-trimethoxybenzoyl)amino]methyl]amino]-2-methylphenyl]-[1,1'-Biphenyl]-4-carboxamide;1359944-60-7 (HCl salt)|
|Solubility||Soluble in DMSO|
|Application||Hh-pathway related diseases|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
MRT-92 HCl salt
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