Moxonidine hydrochloride - CAS 75536-04-8
Catalog number:
75536-04-8
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C9H13Cl2N5O
Molecular Weight:
278.14
COA:
Inquire
Targets:
Adrenergic Receptor | Imidazoline Receptor
Description:
Moxonidine hydrochloride is a mixed agonist of α2-adrenergic receptor (α2AR) and imidazoline-1 receptor(I1R). Its Ki values is 4.2±3.2 nmol/L, 13.0±4.2 nmol/L, 9.5±4.1 nmol/L and 15.6±9.8 nmol/L for I1R, α2AAR, α2BAR and α2CAR, respectively. It is used as antihypertensive agent. It displays 40-fold higher affinity for I1 receptors versus α2-adrenoceptors. It reduced stimulated NE overflow (log EC50: -6.15 +/- 0.14). It has been reported to produce dose-dependent analgesia in multiple acute pain assays and has been reported to potently inhibit the binding of [3H]-clonidine to VLM (ventrolateral medulla) membranes in a dose-dependent manner with the IC50 value of 53 ± 10nM. It has shown low affinity for I2-relative to I1R sites in bovine adrenal medullary cells.
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Purity:
98%
Appearance:
White solid
Synonyms:
BDF5895 hydrochloride;4-Chloro-6-methoxy-2-methyl-5-(2-imidazolin-2-yl)aminopyrimidine hydrochloride
Solubility:
100 mM in ethanol;100 mM in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Moxonidine hydrochloride is used as antihypertensive agent. It has been reported to produce dose-dependent analgesia in multiple acute pain assays and has been reported to potently inhibit the binding of [3H]-clonidine to VLM (ventrolateral medulla) membranes in a dose-dependent manner with the IC50 value of 53 ± 10nM.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Grams to Kilograms
Boiling Point:
364.7 °C at 760 mmHg
Melting Point:
189ºC
Density:
1.52 g/cm3
InChIKey:
ZZPAWQYZQVUVHX-UHFFFAOYSA-N
InChI:
InChI=1S/C9H12ClN5O.ClH/c1-5-13-7(10)6(8(14-5)16-2)15-9-11-3-4-12-9;/h3-4H2,1-2H3,(H2,11,12,15);1H
Canonical SMILES:
CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC.Cl
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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