Moxisylyte hydrochloride - CAS 964-52-3
Catalog number: 964-52-3
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Adrenergic Receptor
Moxisylyte hydrochloride is alpha 1-adrenoceptor antagonist. It can vasodilates cerebral vessels without reducing blood pressure. It is used as peripheral vasodilator. It is also used locally in the eye to reverse the mydriasis caused by phenylephrine. It is used as sympathomimetic agents. It has been listed.
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Carvacrol,5-[2-(dimethylamino)ethoxy]-, acetate (ester), hydrochloride (8CI);Phenol,4-[2-(dimethylamino)ethoxy]-2-methyl-5-(1-methylethyl)-, acetate (ester),hydrochloride (9CI);4-(2-Dimethylaminoethoxy)-5-isopropyl-2-methylphenyl acetatehydrochloride;Opilon hydrochloride;(2-(4-acetoxy-2-isopropyl-5-methylphenoxy)ethyl)dimethylaminehydrochloride;5-(2-(N,N-dimethylamino)ethoxy)carvacrolacetatehydrochloride;Arlitene;Vasoklin;Moxisylyte HCl;[4-[2-(dimethylamino)ethoxy]-2-methyl-5-propan-2-ylphenyl] acetate;hydrochloride;Thymoxamine hydrochloride
Soluble in ethanol (50 mg/ml)
-20°C Freezer
Moxisylyte hydrochloride is used as peripheral vasodilator. It is also used as sympathomimetic agents.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Grams to Kilograms
Melting Point:
208-210 °C
Canonical SMILES:
Current Developer:
Moxisylyte hydrochloride has been listed.
1.Oral vasodilators for primary Raynaud's phenomenon.
Vinjar B1, Stewart M. Cochrane Database Syst Rev. 2008 Apr 16;(2):CD006687. doi: 10.1002/14651858.CD006687.pub2.
BACKGROUND: Many different drugs have been suggested for the symptomatic treatment of primary Raynaud's phenomenon. Apart from calcium channel blockers, which are considered the drugs of choice, the evidence of the effects of alternative pharmacological treatments is limited.
2.Raynaud's phenomenon (primary).
Pope JE1. BMJ Clin Evid. 2008 Dec 16;2008. pii: 1119.
INTRODUCTION: Raynaud's phenomenon is an episodic vasospasm of the peripheral arteries, causing pallor followed by cyanosis and redness with pain and sometimes paraesthesia. On rare occasions it can lead to ulceration of the fingers and toes (and in some cases of the ears or nose). This review focuses on primary (idiopathic) Raynaud's phenomenon occurring in the absence of an underlying disease. The prevalence of primary Raynaud's phenomenon varies by sex, country, and exposure to workplace vibration.
3.Noradrenergic control of GnRH release from the ewe hypothalamus in vitro: sensitivity to oestradiol.
Ghuman SP1, Jones DN, Prabhakar S, Smith RF, Dobson H. Reprod Domest Anim. 2008 Dec;43(6):753-9. doi: 10.1111/j.1439-0531.2007.00997.x. Epub 2008 May 13.
The present study investigates the influence of alpha(1)-adrenoreceptors in GnRH release in vitro and determines whether oestradiol modulates alpha(1)-adrenoreceptor-GnRH interaction. Within 10 min after ewe sacrifice, saggital midline hypothalamic slices were dissected, placed in oxygenated Minimum Essential Media-alpha (MEM-alpha) at 4 degrees C and within 2 h were singly perifused at 37 degrees C with oxygenated MEM-alpha (pH 7.4; flow rate 0.15 ml/min), either with or without oestradiol (24 pg/ml). After 4-h equilibration, 10-min fractions were collected for 4 h interposed with a 10-min exposure at 60 min to specific alpha(1)-adrenoreceptor agonist (methoxamine) or antagonist (thymoxamine) at various doses (0.1-10 mm). The alpha(1)-adrenoreceptor agonist (10 mm) increased (p < 0.05) GnRH release at 90 min both in presence and absence of oestradiol. However, in presence of oestradiol, alpha(1)-adrenoreceptor agonist (10 mm)-induced GnRH release remained elevated (p < 0.
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CAS 964-52-3 Moxisylyte hydrochloride

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