Mosapride - CAS 112885-41-3
Catalog number: 112885-41-3
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C21H25ClFN3O3
Molecular Weight:
421.90
COA:
Inquire
Targets:
5-HT Receptor
Description:
Mosapride, a selective agonist of 5-HT4 receptor, could be used as a astroprokinetic agent. It is also found to be a 5-HT3 receptor antagonist.
Publictions citing BOC Sciences Products
  • >> More
Purity:
98%
Appearance:
White to Off-White Crystalline Solid
Synonyms:
MOSAPRIDE;4-AMINO-5-CHLORO-2-ETHOXY-N-((4-(4-FLUOROBENZYL)-2-MORPHOLINYL)METHYL)BENZAMIDE;4-AMINO-5-CHLORO-2-ETHOXY-N-[4-(4-FLUORO-BENZYL)-MORPHOLIN-2-YLMETHYL]-BENZAMIDE;4-AMINO-5-CHLORO-2-ETHOXY-N-[[[4-(4-FLUOROPHENYL)METHYL]-2-MORPHOLINYL]METHYL]-BENZ
Solubility:
10mM in Ethanol
Storage:
-20ºC Freeze
MSDS:
Inquire
Application:
Mosapride is a selective agonist of 5-HT4 receptor and could be used as a astroprokinetic agent. It is also found to be a 5-HT3 receptor antagonist.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
Boiling Point:
549.2ºC at 760 mmHg
Melting Point:
151-153ºC
Density:
1.272 g/cm3
InChIKey:
YPELFRMCRYSPKZ-UHFFFAOYSA-N
InChI:
InChI=1S/C21H25ClFN3O3/c1-2-28-20-10-19(24)18(22)9-17(20)21(27)25-11-16-13-26(7-8-29-16)12-14-3-5-15(23)6-4-14/h3-6,9-10,16H,2,7-8,11-13,24H2,1H3,(H,25,27)
Canonical SMILES:
CCOC1=CC(=C(C=C1C(=O)NCC2CN(CCO2)CC3=CC=C(C=C3)F)Cl)N
1.A case of advanced systemic sclerosis with severe GERD successfully treated with acotiamide.
Kato R1, Nakajima K2,3, Takahashi T1, Miyazaki Y1, Makino T1, Kurokawa Y1, Yamasaki M1, Takiguchi S1, Mori M1, Doki Y1. Surg Case Rep. 2016 Dec;2(1):36. doi: 10.1186/s40792-016-0162-5. Epub 2016 Apr 13.
The majority of systemic sclerosis (SSc) patients have gastrointestinal tract involvement, but therapies of prokinetic agents are usually unsatisfactory. Patients are often compromised by the use of steroid; therefore, a surgical indication including fundoplication has been controversial. There is no report that advanced SSc with severe gastroesophageal reflux disease (GERD) is successfully treated with acotiamide, which is the acetylcholinesterase (AChE) inhibitor designed for functional dyspepsia (FD). We report a 44-year-old woman of SSc with severe GERD successfully treated with acotiamide. She had received medical treatment in our hospital since 2003. She had been aware of the significant gastroesophageal reflux symptoms (e.g., heartburn, chest pain, and dysphagia) due to the development of esophageal hardening associated with SSc since 2014. As a result of upper gastrointestinal series, upper gastrointestinal endoscopy, and 24-h pH monitoring and frequency scale for the symptoms of the GERD (FSSG) scoring, she has been diagnosed with GERD associated with SSc.
2.Combination could be another tool for bowel preparation?
Soh JS1, Kim KJ1. World J Gastroenterol. 2016 Mar 14;22(10):2915-21. doi: 10.3748/wjg.v22.i10.2915.
Optimal bowel preparation increases the cecal intubation rate and detection of neoplastic lesions while decreasing the procedural time and procedural-related complications. Although high-volume polyethylene glycol (PEG) solution is the most frequently used preparation for bowel cleansing, patients are often unwilling to take PEG solution due to its large volume, poor palatability, and high incidence of adverse events, such as abdominal bloating and nausea. Other purgatives include osmotic agents (e.g., sodium phosphate, magnesium citrate, and sodium sulfate), stimulant agents (e.g., senna, bisacodyl, and sodium picosulfate), and prokinetic agents (e.g., cisapride, mosapride, and itopride). A combination of PEG with an osmotic, stimulant, or prokinetic agent could effectively reduce the PEG solution volume and increase patients' adherence. Some such solutions have been found in several published studies to not be inferior to PEG alone in terms of bowel cleansing quality.
3.Activation of 5-HT4 receptors facilitates neurogenesis of injured enteric neurons at an anastomosis in the lower gut.
Takaki M1, Goto K, Kawahara I, Nabekura J. J Smooth Muscle Res. 2015;51(0):82-94. doi: 10.1540/jsmr.51.82.
Two-photon microscopy (2PM) can enable high-resolution deep imaging of thick tissue by exciting a fluorescent dye and protein at anastomotic sites in the mouse small intestine in vivo. We performed gut surgery and transplanted neural stem cells (NSC) from the embryonic central nervous system after marking them with the fluorescent cell linker, PKH26. We found that neurons differentiated from transplanted NSC (PKH [+]) and newborn enteric neurons differentiated from mobilized (host) NSC (YFP [+]) could be localized within the granulation tissue of anastomoses. A 5-HT4-receptor agonist, mosapride citrate (MOS), significantly increased the number of PKH (+) and YFP (+) neurons by 2.5-fold (P<0.005). The distribution patterns of PKH (+) neurons were similar to those of YFP (+) neurons. On the other hand, the 5-HT4-receptor antagonist, SB-207266 abolished these effects of MOS. These results indicate that neurogenesis from transplanted NSC is facilitated by activation of 5-HT4-receptors.
4.The effect of Flos Lonicerae Japonicae extract on gastro-intestinal motility function.
Nam Y1, Lee JM2, Wang Y3, Ha HS4, Sohn UD5. J Ethnopharmacol. 2016 Feb 17;179:280-90. doi: 10.1016/j.jep.2015.12.056. Epub 2015 Dec 29.
ETHNOPHARMACOLOGICAL RELEVANCE: Flos Lonicerae Japonicae is a well-known herb of traditional Chinese medicine that has been used for heat-clearing, detoxification, anti-inflammation, throat pain and gastro-intestinal (GI) disorder. In order to verify the effect of Flos Lonicerae Japonicae on GI disorder, we investigated the prokinetic effect of GC-7101 on GI motility function.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related 5-HT Receptor Products


Lumateperone Tosylate
(CAS: 1187020-80-9)

The tosylate salt form of Lumateperone which is an highly effective antagonist of 5-HT2A receptor, could be used against insomnia. IC50: 0.54 nM(Ki).

PR-073

PR-073 is a novel 5-HT7 antagonist, which can inhibit immune responses and treat inflammatory bowel disease (IBD). Preclinical studies demonstrated that PR-073 ...

CAS 123040-94-8 (+)-Azasetron hydrochloride

(+)-Azasetron hydrochloride
(CAS: 123040-94-8)

The (+)-enantiomer of Azasetron hydrochloride, which is a selective 5-HT3 antagonist.

CAS 119363-61-0 (R)-(+)-8-Methoxy-2-aminotetraline hydrochloride

(R)-(+)-8-Methoxy-2-aminotetraline hydro
(CAS: 119363-61-0)

(R)-(+)-8-Methoxy-2-Aminotetraline hydrochloride is a 5-HT1A agonist.

LY 426965 dihydrochloride

LY 426965 dihydrochloride is a potent and selective 5-HT1A antagonist that is more active than its opposite enantiomer (R)-(-)-LY 426965.

CAS 72797-41-2 Tianeptine

Tianeptine
(CAS: 72797-41-2)

Tianeptine is a selective facilitator of 5-HT uptake in vitro and in vivo with psychostimulant, anti-ulcer and anti-emetic properties.

CAS 83688-84-0 Tertatolol

Tertatolol
(CAS: 83688-84-0)

Tertatolol, a benzothiopyran derivative, is a potent dual antagonist of beta-adrenoceptor and 5-HT receptor, with antihypertensive effect.

CAS 23047-25-8 Lofepramine

Lofepramine
(CAS: 23047-25-8)

Lofepramine is a serotonin and noradrenalin reuptake inhibitor as an antidepressant.

CAS 1185136-22-4 LP 12 hydrochloride

LP 12 hydrochloride
(CAS: 1185136-22-4)

LP 12 hydrochloride is a 5-HT7 receptor agonist. It can induce relaxation of substance P-induced contractions in guinea pig ileum with EC50 value of 1.77 μM.

CAS 67250-10-6 MK 212 hydrochloride

MK 212 hydrochloride
(CAS: 67250-10-6)

MK 212 hydrochloride is a 5-HT2C receptor agonist.

CAS 133364-62-2 DV 7028 hydrochloride

DV 7028 hydrochloride
(CAS: 133364-62-2)

The hydrochloride salt form of DV 7028, which has been found to be a 5-HT2A receptor antagonist and could restrain collagen-induced serotonin secretion and plat...

CAS 969-33-5 Cyproheptadine hydrochloride

Cyproheptadine hydrochloride
(CAS: 969-33-5)

Cyproheptadine is a non-selective histamine receptor antagonist for 5-HT2 receptor with IC50 of 0.6 nM. It is a first-generation antihistamine with additional a...

CAS 6202-23-9 Cyclobenzaprine HCl

Cyclobenzaprine HCl
(CAS: 6202-23-9)

Cyclobenzaprine HCl is a muscle relaxant, potentially through the gamma fibers which innervate and inhibit the alpha motor neurons in the ventral horn of the sp...

CAS 13523-86-9 Pindolol

Pindolol
(CAS: 13523-86-9)

Pindolol, an Indole derivative, could be used in the treatment of hypertension and arrhythmia for acting as a 5-HT1A/1B receptor antagonist. IC50: 33nM(Ki).

CAS 17321-77-6 Clomipramine HCl

Clomipramine HCl
(CAS: 17321-77-6)

Clomipramine HCl is a hydrochloride salt of clomipramine which is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) bl...

CAS 213007-95-5 Org 37684

Org 37684
(CAS: 213007-95-5)

Org 37684 is a 5-HT2C receptor agonist.

CAS 1417343-80-6 SDZ SER 082 fumarate

SDZ SER 082 fumarate
(CAS: 1417343-80-6)

SDZ SER 082 fumarate is a selective 5-HT2B/2C receptor antagonist with low affinity for 5-HT1A receptors. SDZ SER 082 fumarate inhibits [3H]-mesulergine binding...

CAS 167144-80-1 R-96544 hydrochloride

R-96544 hydrochloride
(CAS: 167144-80-1)

R-96544, the active form of R-102444, is a novel 5-HT receptor antagonist with potent, competitive, and 5-HT(2A)-selective activity (Ki = 1.6 nM). IC50= 2.2, 31...

CAS 148688-01-1 SB 204070

SB 204070
(CAS: 148688-01-1)

SB 204070 is a potent and selective 5-HT4 receptor antagonist (pIC50 = 10.1), displaying >5000-fold selectivity over 5-HT1A, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2C, and...

CAS 313984-77-9 PU 02

PU 02
(CAS: 313984-77-9)

PU 02 is a potent and selective 5-HT3 receptor antagonist (IC50 values are 0.36 and 0.73 μM in HEK293 cells transfected with human 5-HT3A and 5-HT3AB receptors ...

Chemical Structure

CAS 112885-41-3 Mosapride

Quick Inquiry

Verification code

Featured Items