Mosapride - CAS 112885-41-3
Catalog number: 112885-41-3
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C21H25ClFN3O3
Molecular Weight:
421.90
COA:
Inquire
Targets:
5-HT Receptor
Description:
Mosapride, a selective agonist of 5-HT4 receptor, could be used as a astroprokinetic agent. It is also found to be a 5-HT3 receptor antagonist.
Purity:
98%
Appearance:
White to Off-White Crystalline Solid
Synonyms:
MOSAPRIDE;4-AMINO-5-CHLORO-2-ETHOXY-N-((4-(4-FLUOROBENZYL)-2-MORPHOLINYL)METHYL)BENZAMIDE;4-AMINO-5-CHLORO-2-ETHOXY-N-[4-(4-FLUORO-BENZYL)-MORPHOLIN-2-YLMETHYL]-BENZAMIDE;4-AMINO-5-CHLORO-2-ETHOXY-N-[[[4-(4-FLUOROPHENYL)METHYL]-2-MORPHOLINYL]METHYL]-BENZ
Solubility:
10mM in Ethanol
Storage:
-20ºC Freeze
MSDS:
Inquire
Application:
Mosapride is a selective agonist of 5-HT4 receptor and could be used as a astroprokinetic agent. It is also found to be a 5-HT3 receptor antagonist.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
Boiling Point:
549.2ºC at 760 mmHg
Melting Point:
151-153ºC
Density:
1.272 g/cm3
InChIKey:
YPELFRMCRYSPKZ-UHFFFAOYSA-N
InChI:
InChI=1S/C21H25ClFN3O3/c1-2-28-20-10-19(24)18(22)9-17(20)21(27)25-11-16-13-26(7-8-29-16)12-14-3-5-15(23)6-4-14/h3-6,9-10,16H,2,7-8,11-13,24H2,1H3,(H,25,27)
Canonical SMILES:
CCOC1=CC(=C(C=C1C(=O)NCC2CN(CCO2)CC3=CC=C(C=C3)F)Cl)N
1.A case of advanced systemic sclerosis with severe GERD successfully treated with acotiamide.
Kato R1, Nakajima K2,3, Takahashi T1, Miyazaki Y1, Makino T1, Kurokawa Y1, Yamasaki M1, Takiguchi S1, Mori M1, Doki Y1. Surg Case Rep. 2016 Dec;2(1):36. doi: 10.1186/s40792-016-0162-5. Epub 2016 Apr 13.
The majority of systemic sclerosis (SSc) patients have gastrointestinal tract involvement, but therapies of prokinetic agents are usually unsatisfactory. Patients are often compromised by the use of steroid; therefore, a surgical indication including fundoplication has been controversial. There is no report that advanced SSc with severe gastroesophageal reflux disease (GERD) is successfully treated with acotiamide, which is the acetylcholinesterase (AChE) inhibitor designed for functional dyspepsia (FD). We report a 44-year-old woman of SSc with severe GERD successfully treated with acotiamide. She had received medical treatment in our hospital since 2003. She had been aware of the significant gastroesophageal reflux symptoms (e.g., heartburn, chest pain, and dysphagia) due to the development of esophageal hardening associated with SSc since 2014. As a result of upper gastrointestinal series, upper gastrointestinal endoscopy, and 24-h pH monitoring and frequency scale for the symptoms of the GERD (FSSG) scoring, she has been diagnosed with GERD associated with SSc.
2.Combination could be another tool for bowel preparation?
Soh JS1, Kim KJ1. World J Gastroenterol. 2016 Mar 14;22(10):2915-21. doi: 10.3748/wjg.v22.i10.2915.
Optimal bowel preparation increases the cecal intubation rate and detection of neoplastic lesions while decreasing the procedural time and procedural-related complications. Although high-volume polyethylene glycol (PEG) solution is the most frequently used preparation for bowel cleansing, patients are often unwilling to take PEG solution due to its large volume, poor palatability, and high incidence of adverse events, such as abdominal bloating and nausea. Other purgatives include osmotic agents (e.g., sodium phosphate, magnesium citrate, and sodium sulfate), stimulant agents (e.g., senna, bisacodyl, and sodium picosulfate), and prokinetic agents (e.g., cisapride, mosapride, and itopride). A combination of PEG with an osmotic, stimulant, or prokinetic agent could effectively reduce the PEG solution volume and increase patients' adherence. Some such solutions have been found in several published studies to not be inferior to PEG alone in terms of bowel cleansing quality.
3.Activation of 5-HT4 receptors facilitates neurogenesis of injured enteric neurons at an anastomosis in the lower gut.
Takaki M1, Goto K, Kawahara I, Nabekura J. J Smooth Muscle Res. 2015;51(0):82-94. doi: 10.1540/jsmr.51.82.
Two-photon microscopy (2PM) can enable high-resolution deep imaging of thick tissue by exciting a fluorescent dye and protein at anastomotic sites in the mouse small intestine in vivo. We performed gut surgery and transplanted neural stem cells (NSC) from the embryonic central nervous system after marking them with the fluorescent cell linker, PKH26. We found that neurons differentiated from transplanted NSC (PKH [+]) and newborn enteric neurons differentiated from mobilized (host) NSC (YFP [+]) could be localized within the granulation tissue of anastomoses. A 5-HT4-receptor agonist, mosapride citrate (MOS), significantly increased the number of PKH (+) and YFP (+) neurons by 2.5-fold (P<0.005). The distribution patterns of PKH (+) neurons were similar to those of YFP (+) neurons. On the other hand, the 5-HT4-receptor antagonist, SB-207266 abolished these effects of MOS. These results indicate that neurogenesis from transplanted NSC is facilitated by activation of 5-HT4-receptors.
4.The effect of Flos Lonicerae Japonicae extract on gastro-intestinal motility function.
Nam Y1, Lee JM2, Wang Y3, Ha HS4, Sohn UD5. J Ethnopharmacol. 2016 Feb 17;179:280-90. doi: 10.1016/j.jep.2015.12.056. Epub 2015 Dec 29.
ETHNOPHARMACOLOGICAL RELEVANCE: Flos Lonicerae Japonicae is a well-known herb of traditional Chinese medicine that has been used for heat-clearing, detoxification, anti-inflammation, throat pain and gastro-intestinal (GI) disorder. In order to verify the effect of Flos Lonicerae Japonicae on GI disorder, we investigated the prokinetic effect of GC-7101 on GI motility function.
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CAS 112885-41-3 Mosapride

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