Monobenzone - CAS 103-16-2
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Not Intended for Therapeutic Use. For research use only.
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Monobenzone is a compound used as a topical agent for medical depigmentation.The topical application of monobenzone in animals decreases the excretion of melanin from melanocytes.
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1.Melasma and laser treatment: an evidenced-based analysis
Shlomit Halachmi & Merete Haedersdal & Moshe Lapidoth. Lasers Med Sci (2014) 29:589–598
Traditional approaches to melasma have met with partial and temporary success. Cessation of oral contraceptives may not reverse melasma in prone individuals. The most commonly advised treatment begins with meticulous sun avoidance and use of sun protection products, which approach on its own yields improvement. Additional therapies have relied on bleaching agents, primarily hydroquinone, which blocks the activity of tyrosinase, the rate-limiting enzyme in melanin synthesis in melanocytes. Additional strategies to block pigmentation include the use of a host of topical remedies which block melanin formation, inhibit the response to melancyte-stimulating hormone, or prevent melanosome transport. A few treatments target previously synthesized melanin by depigmenting the skin either temporarily (e.g., lignin peroxidase) or permanently (e.g., monobenzone), though the latter should be assessed critically. Of topical therapies, hydroquinone had been considered the gold standard, but recent safety concerns, including the risk of exogenous ochronosis or more serious effects due to its cytotoxic effects and its alteration of mitochondrial functioning, have reduced its availability worldwide, despite the lack of clear clinical evidence.
2. Biochemical constituents of a wild strain of Schizophyllum commune isolated from Achanakmar-Amarkantak Biosphere Reserve (ABR), India
Arpita Mani Tripathi • Bhupendra N. Tiwary. World J Microbiol Biotechnol (2013) 29:1431–1442
GC–MS analysis revealed the presence of two phenolic compounds in ethanolic extract of in vitro grown fruiting bodies. The first spot with Rf value 0.53 on silica gel sheet was detected at 11.42 retention time during mass analysis. In the mass spectrum of the compound, the major peak was identified by the NBS 98-MS database library as Phenyl benzoate (Benzoic acid, phenyl ester)—C13H10O2 with a molecular weight of 198 (Fig. 1). Similarly the UV absorption spectrum of the above identified compound was measured at 313 nm. The second spot with Rf value 0.94 on silica gel was detected at 9.09 retention time and the major peak of the compound was identified as 4-(phenyl methoxy) phenol (Monobenzone)—C13H12O2 with a molecular weight of 200 (Fig. 2) and the UV absorption spectrum of the compound was measured at 255 nm.
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CAS 103-16-2 Monobenzone

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