Molindone hydrochloride - CAS 15622-65-8
Catalog number: 15622-65-8
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Dopamine Receptor
Molindone hydrochloride, an indole derivative, as an antipsychotic agent it blocks the effects of dopamine in the brain which can be used for the treatment of schizophrenia.
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3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one;hydrochloride Endo Brand of Molindone Hydrochloride Hydrochloride, Molindone Moban Molindone Molindone Hydrochloride Molindone Monohydrochloride Monohydrochloride, Molindone
Soluble to 15mg/mL in DMSO
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -86℃ for long term (months to years).
Shelf Life:
2 years
Canonical SMILES:
1.In vitro and in vivo genotoxicity assessment of the dopamine receptor antagonist molindone hydrochloride.
Krishna G1, Gopalakrishnan G1, Goel S1. Environ Mol Mutagen. 2016 May;57(4):288-98. doi: 10.1002/em.22007. Epub 2016 Apr 4.
Molindone hydrochloride is a dihydroindolone neuroleptic with dopamine D2 and D5 receptor antagonist activity. As an integral component of its preclinical safety evaluation, molindone hydrochloride was evaluated in a series of in vitro and in vivo genetic toxicology assays. In the bacterial reverse gene mutation assays employing four Salmonella tester strains (TA98, TA100, TA1535, and TA1537) and the E. coli tester strain WP2uvrA, molindone hydrochloride was negative in all strains, except TA100, in which it induced a positive response (up to 3-fold) in the presence of rat liver S9. With human S9, a small (2-fold), but nonreproducible, increase in revertants was observed in TA100 at the highest concentration of molindone tested (5,000 µg/plate). The mutagenicity was completely abrogated by the addition of glutathione and UDP-glucuronic acid to rat liver S9, suggesting detoxification of the mutagenic metabolite(s) by Phase II conjugation reactions, pathways commonly operational in humans.
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CAS 15622-65-8 Molindone hydrochloride

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