Moguisteine - CAS 119637-67-1
Catalog number: 119637-67-1
Category: Inhibitor
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Molecular Formula:
C16H21NO5S
Molecular Weight:
339.41
COA:
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Targets:
Others
Description:
Moguisteine is a novel peripheral nonnarcotic antitussive agent that has proved to be as active as codeine in several experimental models of induced cough in guinea-pigs and dogs.
Purity:
>98%
Synonyms:
BBR-2173; BBR2173; BBR 2173
MSDS:
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InChIKey:
WSYVIAQNTFPTBI-UHFFFAOYSA-N
InChI:
InChI=1S/C16H21NO5S/c1-3-21-16(19)10-14(18)17-8-9-23-15(17)11-22-13-7-5-4-6-12(13)20-2/h4-7,15H,3,8-11H2,1-2H3
Canonical SMILES:
CCOC(=O)CC(=O)N1CCSC1COC2=CC=CC=C2OC
1.Effects of four antitussives on airway neurogenic inflammation in a guinea pig model of chronic cough induced by cigarette smoke exposure.
Luo YL1, Li PB, Zhang CC, Zheng YF, Wang S, Nie YC, Zhang KJ, Su WW. Inflamm Res. 2013 Dec;62(12):1053-61. doi: 10.1007/s00011-013-0664-6. Epub 2013 Oct 2.
OBJECTIVE: The effects of four antitussives, including codeine phosphate (CP), moguisteine, levodropropizine (LVDP) and naringin, on airway neurogenic inflammation and enhanced cough were investigated in guinea pig model of chronic cough.
2.Over-the-counter medications for acute cough in children and adults in ambulatory settings.
Schroeder K1, Fahey T. Cochrane Database Syst Rev. 2004 Oct 18;(4):CD001831.
BACKGROUND: Acute cough due to upper respiratory tract infection (URTI) is a common symptom. Many health practitioners recommend non-prescription over-the-counter (OTC) medicines as a first-line treatment for cough, but there is little evidence as to whether these drugs are effective.
3.Determination of the active metabolite of moguisteine in human plasma and urine by LC-ESI-MS method and its application in pharmacokinetic study.
Teng Y1, Song H, Bu F, Wei C, Zhao W, Zhang R, Yuan G, Liu X, Wang B, Guo R. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jun 15;899:31-5. doi: 10.1016/j.jchromb.2012.04.033. Epub 2012 May 4.
In this study, a sensitive and reproducible electro-spray ionization liquid chromatography-mass spectrometry (LC-ESI-MS) method was established to determine the concentration of M1, the main active metabolite of moguisteine in human plasma and urine. The analysis was performed on a Diamonsil® C₁₈(2) column (150 mm × 4.6 mm, 5 μm) with the mobile phase consisting of 0.1% formic acid-acetonitrile (57:43, v/v, pH=3.0) at a flow rate of 0.8 mL min⁻¹. The pseudo-molecular ions [M+H]+ (m/z 312.2 for M1 and 446.3 for glipizide) were selected as the target ions for quantification in the selected ion monitoring (SIM) mode. Plasma samples were analyzed after being processed by acidification with formic acid and protein precipitation with acetonitrile. Urine samples were appropriately diluted with blank urine for analysis. Calibration curve was ranged from 0.02 to 8 μg mL⁻¹. The extraction recovery in plasma was over 90%. Both the inter- and intra-day precision values were less than 7.
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CAS 119637-67-1 Moguisteine

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