Moclobemide - CAS 71320-77-9
Catalog number:
71320-77-9
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C13H17ClN2O2
Molecular Weight:
268.74
COA:
Inquire
Targets:
Others
Description:
Moclobemide is a reversible monoamine oxidase A (MOA-A) inhibitor.
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Purity:
>98%
Synonyms:
Arotinoid Acid
MSDS:
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1.The separate and combined effects of monoamine oxidase A inhibition and nicotine on resting state EEG.
Smith DM1, Fisher D2, Blier P3, Ilivitsky V4, Knott V3. J Psychopharmacol. 2016 Jan;30(1):56-62. doi: 10.1177/0269881115613518. Epub 2015 Nov 4.
While nicotine is often associated with the neuropsychological effects of tobacco smoke, the robust monoamine oxidase (MAO) inhibition observed in chronic smokers is also likely to play a role. Electroencephalographically-indexed alterations in baseline neural oscillations by nicotine have previously been reported in both smokers and non-smokers, however, little is known about the effects of MAO inhibition in combination with nicotine on resting state EEG. In a sample of 24 healthy non-smoking males, the effects of 6 mg nicotine gum, as well as MAO-A inhibition via 75 mg moclobemide, were investigated in separate and combined conditions over four separate test sessions. Drug effects were observed in the alpha2, beta2, and theta band frequencies. Nicotine increased alpha2 power, and moclobemide decreased beta2 power. Theta power was decreased most robustly by the combination of both drugs. Therefore, this study demonstrated that the nicotinic and MAO inhibiting properties of tobacco may differentially influence fast-wave oscillations (alpha2 and beta2), while acting in synergy to influence theta oscillations.
2.Monoamine Oxidase Inhibitory Activity of Novel Pyrazoline Analogues: Curcumin Based Design and Synthesis.
Badavath VN1, Baysal İ2, Ucar G2, Sinha BN1, Jayaprakash V1. ACS Med Chem Lett. 2015 Dec 1;7(1):56-61. doi: 10.1021/acsmedchemlett.5b00326. eCollection 2016.
A series of new 2-methoxy-4-(5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenolderivatives, 4-13, were synthesized and tested for their human MAO inhibitory activity. All the compounds were found to be selective and reversible toward hMAO-A except 4, a selective inhibitor of hMAO-B and 12, a nonselective inhibitor. Compound 7 was found to be a potent inhibitor of hMAO-A with Ki = 0.06 ± 0.003 μM and was having selectivity index of (SI = 1.02 × 10(-5)). It was found to be better than standard drug, Moclobemide (hMAO-A with Ki = 0.11 ± 0.01 μM) with selectivity index of SI = 0.049. Molecular docking simulation was carried out to understand the crucial interactions responsible for selectivity and potency.
3.Differences in prescribing psychotropic drugs for elderly with depression.
Huang YC1, Wang LJ2, Chong MY1. Acta Neuropsychiatr. 2016 Feb 22:1-8. [Epub ahead of print]
OBJECTIVE: The escalating tendency of elderly population aged 65 and over, which grown up to 9% since 2001 in Taiwan, remarks the important issue of mental health among ageing population. Depression in the elderly is frequently undetected or inadequately treated. This study aimed to investigate the pharmacotherapy of elderly patients with depression by comparing the patterns of prescribing psychotropic drugs (psychotropics) of psychiatrists and non-psychiatrists.
4.Visible-Light-Mediated Synthesis of Amides from Aldehydes and Amines via in Situ Acid Chloride Formation.
Iqbal N1, Cho EJ2. J Org Chem. 2016 Mar 4;81(5):1905-11. doi: 10.1021/acs.joc.5b02726. Epub 2016 Feb 16.
An efficient visible-light photocatalysis-based one-pot amide synthesis method was developed; visible-light irradiation of a mixture of an aldehyde, tert-butyl hydrogen peroxide, and N-chlorosuccinimide using a Ru(bpy)3Cl2 photocatalyst afforded an acid chloride, which subsequently reacted with amine to yield the corresponding amide. The reaction was used to synthesize moclobemide and a D3 receptor intermediate.
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CAS 71320-77-9 Moclobemide

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