MMAF - CAS 745017-94-1
Catalog number:
745017-94-1
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C39H65N5O8
Molecular Weight:
731.96
COA:
Inquire
Targets:
ADCs Cytotoxin
Description:
MMAF is an antitubulin agent that inhibit cell division by blocking the polymerization of tubulin and it has lower cytotoxic activity than MMAE. It is an antibody drug cytotoxin. It induces potent antitumor effects when conjugated via protease cleavable linkers to a monoclonal antibody targeting internalizing, tumor-specific cell surface antigens.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Synonyms:
Monomethylauristatin F
MSDS:
Inquire
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related ADCs Cytotoxin Products


CAS 57103-68-1 Maytansinol

Maytansinol
(CAS: 57103-68-1)

Maytansinol disrupts the mitotic spindle and prevents mitotic exit in Drosophila used in the preparation of site-specific trastuzumab maytansinoid antibody-drug...

CAS 38748-32-2 Triptolide

Triptolide
(CAS: 38748-32-2)

Triptolide is a diterpenoid epoxide found in the Thunder God Vine, Tripterygium wilfordii, which has been used in traditional Chinese medicine for more than two...

CAS 33069-62-4 Taxol

Taxol
(CAS: 33069-62-4)

Taxol, also called Paclitaxel, derived from the bark of the Pacific yew tree, has a broad antineoplastic spectrum uused in cancer chemotherapy.It promotes and s...

CAS 1415246-68-2 MMAF Hydrochloride

MMAF Hydrochloride
(CAS: 1415246-68-2)

MMAF is a new auristatin derivative with a charged C-terminal phenylalanine that attenuates its cytotoxic activity compared to its uncharged counterpart, Monome...

CAS 20830-81-3 Daunorubicin

Daunorubicin
(CAS: 20830-81-3)

Daunorubicin hydrochloride is the hydrochloride salt of an anthracycline antineoplastic antibiotic with therapeutic effects similar to those of doxorubicin. Dau...

CAS 23541-50-6 Daunorubicin hydrochloride

Daunorubicin hydrochloride
(CAS: 23541-50-6)

Daunorubicin HCl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM. It is chemotherapeutic of the anthracycline family that is g...

Aldoxorubicin hydrochloride
(CAS: 480998-12-7)

Aldoxorubicin is the 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin (DOXO-EMCH) with antineoplastic activity.

CAS 23214-92-8 Doxorubicin

Doxorubicin
(CAS: 23214-92-8)

Doxorubicin is an anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hy...

CAS 59-05-2 Methotrexate

Methotrexate
(CAS: 59-05-2)

Methotrexate, a folate antagonist, is a potent anti-inflammatory agent when used weekly in low concentrations, the anti-phlogistic action of which is due to inc...

CAS 23109-05-9 alpha-Amanitin

alpha-Amanitin
(CAS: 23109-05-9)

alpha-Amanitin, the major toxic bicyclic octapeptide of the mushroom Amanita phalloides, inhibits RNA polymerase II at 1 µg/ml, RNA polymerase III at 10 µg/ml a...

CAS 173441-26-4 MMAD hydrochloride

MMAD hydrochloride
(CAS: 173441-26-4)

For comparison purposes, the ADC A1 -mc-MMAD and/or A1 -vc-MMAD were used. The linker payload, mc-MMAD (6-maleimidocaproyl-monomethylauristatin-D) was conjugate...

CAS 202350-68-3 PNU-159682

PNU-159682
(CAS: 202350-68-3)

The cytotoxicity of PNU-159682 were in the subnanomolar range (0.07-0.58 nmol/L) and noticeably lower than that recorded for both MMDX and doxorubicin; PNU-1596...

CAS 66584-72-3 Ansamitocin P-3

Ansamitocin P-3
(CAS: 66584-72-3)

Ansamitocin P-3, a metabolite of Ansamitocin, displays potent cytotoxicity against as a a new maytansinoid antitumor antibiotic.

CAS 7689-03-4 Camptothecin

Camptothecin
(CAS: 7689-03-4)

Camptothecin (CPT) is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I (topo I). It was discovered in 1966 by M. E. Wall and M. C. W...

CAS 203849-91-6 MMAD

MMAD
(CAS: 203849-91-6)

MMAD is a highly potent inhibitor of tubulin.

CAS 163768-50-1 Auristatin F

Auristatin F
(CAS: 163768-50-1)

Auristatin F is a cytotoxic tubulin modifier with potent and selective antitumor activity; MMAF analog and cytotoxin in Antibody-drug conjugates.

CAS 160800-57-7 Auristatin E

Auristatin E
(CAS: 160800-57-7)

Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity; MMAE analog and cytotoxin in Antibody-drug conjugates.

CAS 66547-09-9 Ansamitocin P-3

Ansamitocin P-3
(CAS: 66547-09-9)

Ansamitocin P-3, a potent anti-tumor maytansinoid found in Actinosynnema pretiosum, is a maytansine analog which displays potent cytotoxicity against the human ...

CAS 205304-86-5 Tubulysin A

Tubulysin A
(CAS: 205304-86-5)

Tubulysin A is a myxobacterial product that can function as an antiangiogenic agent in many in vitro assays. Tubulysin A is a novel antibiotic, which is anti-mi...

CAS 108212-75-5 Calicheamicin

Calicheamicin
(CAS: 108212-75-5)

Calicheamicin, also known as Calichemicin γ1, is an potent enediyne antitumor antibiotics derived from the bacterium Micromonospora echinospora. Calicheamicin t...

Chemical Structure

CAS 745017-94-1 MMAF

Quick Inquiry

Verification code

Featured Items